Results 71 to 80 of about 15,728 (128)

Cortical dynein drives centrosome clustering in cells with centrosome amplification. [PDF]

Mol Biol Cell, 2023
Mercadante DL, Aaron WA, Olson SD, Manning AL.   +3 more
europepmc   +1 more source

Inhibiting centrosome clustering reduces cystogenesis and improves kidney function in autosomal dominant polycystic kidney disease

JCI Insight
Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder accounting for approximately 5% of patients with renal failure, yet therapeutics for the treatment of ADPKD remain limited. ADPKD tissues display abnormalities in the biogenesis
Tao Cheng, Aruljothi Mariappan, Ewa Langner, Kyuhwan Shim, Jay Gopalakrishnan, Moe R. Mahjoub   +5 more
doaj   +1 more source

Centrosome Amplification Is a Potential Molecular Target in Paediatric Acute Lymphoblastic Leukemia. [PDF]

Cancers (Basel), 2022
Guo M, Rever J, Nguyen PNU, Akella NM, Reid GSD, Maxwell CA.   +5 more
europepmc   +1 more source

Centrosome – a promising anti-cancer target

Biologics: Targets & Therapy, 2016
Yainyrette Rivera-Rivera, Harold I Saavedra Department of Pharmacology, Ponce Health Sciences University-School of Medicine, Ponce Research Institute, Ponce, Puerto Rico Abstract: The centrosome, an organelle discovered >100 years ago, is the ...
Rivera-Rivera Y, Saavedra HI
doaj  

Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification. [PDF]

Cell Death Differ, 2023
Saatci O, Akbulut O, Cetin M, Sikirzhytski V, Uner M, Lengerli D, O'Quinn EC, Romeo MJ, Caliskan B, Banoglu E, Aksoy S, Uner A, Sahin O.   +12 more
europepmc   +1 more source

Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction

Cell Death and Disease
Unlike normal cells, cancer cells frequently exhibit supernumerary centrosomes, leading to formation of multipolar spindles that can trigger cell death.
Batuhan Mert Kalkan, Selahattin Can Ozcan, Enes Cicek, Mehmet Gonen, Ceyda Acilan   +4 more
doaj   +1 more source

BRCA1 transports the DNA damage signal for CDDP-induced centrosome amplification through the centrosomal Aurora A. [PDF]

Cancer Sci, 2022
Qi H, Kikuchi M, Yoshino Y, Fang Z, Ohashi K, Gotoh T, Ideta R, Ui A, Endo S, Otsuka K, Shindo N, Gonda K, Ishioka C, Miki Y, Iwabuchi T, Chiba N.   +15 more
europepmc   +1 more source

The variant senescence-associated secretory phenotype induced by centrosome amplification constitutes a pathway that activates hypoxia-inducible factor-1α. [PDF]

Aging Cell, 2023
Wu SK, Ariffin J, Tay SC, Picone R.
europepmc   +1 more source

The <i>Chlamydia trachomatis</i> type III-secreted effector protein CteG induces centrosome amplification through interactions with centrin-2. [PDF]

Proc Natl Acad Sci U S A, 2023
Steiert B, Icardi CM, Faris R, McCaslin PN, Smith P, Klingelhutz AJ, Yau PM, Weber MM.   +7 more
europepmc   +1 more source

Postmitotic centriole disengagement and maturation leads to centrosome amplification in polyploid trophoblast giant cells. [PDF]

Mol Biol Cell, 2022
Buss G, Stratton MB, Milenkovic L, Stearns T.   +3 more
europepmc   +1 more source