Results 61 to 70 of about 352 (140)
, 2018 Ceragenins, a novel family of antibiotics, are cationic derivatives of cholic acid and display broad-spectrum antimicrobial activities. Multiple ceragenins have been synthesized and studied, and most published data are with ceragenin CSA-13.
Bozkurt Güzel, Çağla +2 more
core +2 more sources
Design and Synthesis of Ceragenins–Cationic Steroid Antimicrobial Compounds, Structural Improvement and Synthesis of Cyclopentenone Prostaglandins and Modification and Synthesis of Derivatives of Ribityllumazines: Potential Antigens for Activation of MAIT Cells [PDF]
, 2019 Antimicrobial peptides (AMPs) are ubiquitous and display broad-spectrum antimicrobial activity that can control bacterial colonization of surfaces. Ceragenins are small-molecule mimics of AMPs and have several advantages over AMPs, including cost of ...
Li, Yubo
core
Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins [PDF]
Antimicrobial Agents and Chemotherapy, 2017 ABSTRACT The susceptibility of colistin-resistant clinical isolates of Klebsiella pneumoniae to ceragenins and antimicrobial peptides (AMPs) suggests that there is little to no cross-resistance between colistin and ceragenins/AMPs and that lipid A modifications are found in bacteria with modest changes in ...
Hashemi, Marjan M. +5 more
openaire +2 more sources
, 2014 Cells were grown in C+Y at 37°C to an A550 of about 0.2. CSA-13 was then added to an aliquot of the culture and incubation continued without shaking at 37°C. Solid circles represent untreated control cultures. CSA-13 was added (open symbols) at 2.5 µg/ml
Miriam Moscoso (345679) +3 more
core +1 more source
, 2013 One current problem in medicine is the accumulation of biofilm on medical devices. Bacterial colonization of endotracheal tubes and urinary catheters is the leading cause of hospital-acquired infections.
Savage, Dr. Paul B., Clark, Jeffrey
core
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007 Ceragenins are cationic bile salt derivatives having antimicrobial activity. The interactions of several ceragenins with phospholipid bilayers were tested in different systems. The ceragenins are capable of forming specific associations with several phospholipid species that may be involved with their antimicrobial action.
Epand, Raquel F. +2 more
openaire +2 more sources
, 2018 Cationic steroid antimicrobials (CSA-ceragenin) are a new class of antimicrobial agent. In vitro activities of CSA-8, CSA-13, CSA-44, CSA-131, and CSA-138 and amphotericin B (AMP-B) were assessed against 50 nonrepeat Candida spp.
Bozkurt-Guzel, Cagla +5 more
core +1 more source
Selective Nanoparticles for Antimicrobial Therapies and MRI Diagnostics [PDF]
, 2013 Early diagnosis and treatment of an infection and the selectivity of the treatment method are three parameters, which if optimized will greatly enhance a patient’s prognosis.
Hoppens, Mark Andrew +2 more
core +1 more source
Cationic Steroid Antimicrobials: Applications to Medical Device Coatings, Mechanism of Pro-Osteogenic Properties, and Potential Synergy with Common Antifungals [PDF]
, 2021 Cationic steroid antimicrobials (CSAs or ceragenins) are a novel class of synthetic, cholic acid-based mimics of endogenous antimicrobial peptides. These small molecule compounds display broad bactericidal activity against gram-negative and gram-positive
Hilton, Brian J.
core
Effect of CSA-13 on streptococcal species.
, 2014 Exponentially growing cultures were incubated in C+Y to an A550 of about 0.2. CSA-13 was then added to aliquots of the cultures and incubation continued without shaking at 37°C. (a) S. pneumoniae R6. (b) S. pneumoniae Spain23F-1.
Miriam Moscoso (345679) +3 more
core +1 more source