Results 41 to 50 of about 352 (140)

Ceragenins: A Class of Antiviral Compounds to Treat Orthopox Infections [PDF]

Journal of Investigative Dermatology, 2009
Eczema vaccinatum is a potentially fatal, disseminated viral skin infection that develops in individuals with atopic dermatitis after exposure to the vaccinia virus (VV). Despite advances in modern medicine, there are few options for those suffering from disseminated VV infections.
Howell, Michael D., Streib, Joanne E., Kim, Byung Eui, Lesley, Leighann J., Dunlap, Annegret P., Geng, Dianliang, Feng, Yanshu, Savage, Paul B., Leung, Donald Y.M.   +8 more
openaire   +2 more sources

Ceragenins as Mimics of Endogenous Antimicrobial Peptides

Journal of Antimicrobial Agents, 2017
Ceragenins are small molecule mimics of endogenous antimicrobial peptides (AMPs), and as such display broadspectrum antimicrobial activity. These molecules are derived from a common bile acid and can be prepared at a large scale. Because ceragenins are not peptide based, they are not substrates for proteases.
Marjan M Hashemi, Brett S Holden, Bonita DurnaAA, Robert Buck, Paul B Savage   +4 more
openaire   +1 more source

Use of ceragenins as a potential treatment for urinary tract infections [PDF]

BMC Infectious Diseases, 2019
Urinary tract infections (UTIs) are one of the most common bacterial infections. High recurrence rates and the increasing antibiotic resistance among uropathogens constitute a large social and economic problem in current public health. We assumed that combination of treatment that includes the administration ceragenins (CSAs), will reinforce the effect
Urszula Wnorowska, Ewelina Piktel, Bonita Durnaś, Krzysztof Fiedoruk, Paul B. Savage, Robert Bucki   +5 more
openaire   +4 more sources

Use of ceragenins to create novel biofouling resistant water-treatment membranes. [PDF]

, 2008
Scoping studies have demonstrated that ceragenins, when linked to water-treatment membranes have the potential to create biofouling resistant water-treatment membranes.
Savage, Paul B. (Brigham Young University, Provo, UT), Sanchez, Andres L. (LMATA, Albuquerque, NM), Fellows, Benjamin D., Jones, Howland D. T., Feng, Yanshu (Brigham Young University, Provo, UT), Hibbs, Michael R., Altman, Susan Jeanne, Pollard, Jacob (Brigham Young University, Provo, UT), McGrath, Lucas K. (LMATA, Albuquerque, NM)   +8 more
core   +1 more source

New β-Lactam Antibiotics and Ceragenins – A Study to Assess Their Potential in Treatment of Infections Caused by Multidrug-Resistant Strains of Pseudomonas aeruginosa

Infection and Drug Resistance, 2021
Paulina Paprocka,1 Bonita Durnaś,1,2 Angelika Mańkowska,1 Karol Skłodowski,3 Grzegorz Król,1 Magdalena Zakrzewska,3 Michał Czarnowski,3 Patrycja Kot,1 Kamila Fortunka,1 Stanisław Góźdź,2 Paul B Savage,4 ...
Paprocka P, Durnaś B, Mańkowska A, Skłodowski K, Król G, Zakrzewska M, Czarnowski M, Kot P, Fortunka K, Góźdź S, Savage PB, Bucki R   +11 more
doaj  

Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juice

BMC Microbiology, 2009
Background The worldwide appearance of drug-resistant strains of H. pylori motivates a search for new agents with therapeutic potential against this family of bacteria that colonizes the stomach, and is associated with adenocarcinoma development.
Janmey Paul A, Diamond Scott, Savage Paul B, Namiot Zbigniew, Wen Qi, Fein David E, Namiot Andrzej, Leszczyńska Katarzyna, Bucki Robert   +8 more
doaj   +1 more source

Bactericidal activity and biocompatibility of ceragenin-coated magnetic nanoparticles [PDF]

Journal of Nanobiotechnology, 2015
Ceragenins, synthetic mimics of endogenous antibacterial peptides, are promising candidate antimicrobial agents. However, in some settings their strong bactericidal activity is associated with toxicity towards host cells. To modulate ceragenin CSA-13 antibacterial activity and biocompatibility, CSA-13-coated magnetic nanoparticles (MNP-CSA-13) were ...
Katarzyna Niemirowicz, Urszula Wnorowska, Wilczewska, Agnieszka, Mystkowska, Joanna, Ewelina Piktel, Gu, Xiaobo, Zbigniew Namiot, Alina Kułakowska, Savage, Paul, Robert Bucki   +9 more
openaire   +2 more sources

Surfactants: Role in biofilm management and cellular behaviour

International Wound Journal, Volume 16, Issue 3, Page 753-760, June 2019., 2019
Appropriate and effective wound cleaning represents an important process that is necessary for preparing the wound for improved wound healing and for helping to dislodge biofilms. Wound cleaning is of paramount importance to wound bed preparation for helping to enhance wound healing. Surfactant applications in wound care may represent an important area
Steven L. Percival, Dieter Mayer, Robert S. Kirsner, Greg Schultz, Dot Weir, Sashwati Roy, Afsaneh Alavi, Marco Romanelli   +7 more
wiley   +1 more source

Structure of the ceragenin CSA-13.

, 2014
Structure of the ceragenin CSA-13.
Miriam Moscoso (345679), María Esteban-Torres (541709), Ernesto García (131244), Margarita Menéndez (131248)   +3 more
core   +1 more source

Recent Nanotechnology Approaches for Prevention and Treatment of Biofilm‐Associated Infections on Medical Devices

BioMed Research International, Volume 2016, Issue 1, 2016., 2016
Bacterial colonization in the form of biofilms on surfaces causes persistent infections and is an issue of considerable concern to healthcare providers. There is an urgent need for novel antimicrobial or antibiofilm surfaces and biomedical devices that provide protection against biofilm formation and planktonic pathogens, including antibiotic resistant
Mohankandhasamy Ramasamy, Jintae Lee, Ariel Kushmaro   +2 more
wiley   +1 more source