Results 51 to 60 of about 352 (140)

Quantification of Synergistic Effects of Ceragenin CSA-131 Combined with Iron Oxide Magnetic Nanoparticles Against Cancer Cells [Corrigendum]

International Journal of Nanomedicine, 2023
Piktel E, Markiewicz KH, Wilczewska AZ, et al. Int J Nanomedicine. 2020;15:4573–4589. It has been brought to the authors attention that Figure 6E showing nanosystem-mediated DNA fragmentation in DLD-1 colorectal cancer cells is a duplicate of part
Piktel E, Markiewicz KH, Wilczewska AZ, Daniluk T, Chmielewska S, Niemirowicz-Laskowska K, Mystkowska J, Paprocka P, Savage PB, Bucki R   +9 more
doaj  

Potential Synergy Activity of the Novel Ceragenin, CSA‐13, against Carbapenem‐Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Carbapenem‐resistant Acinetobacter baumannii is an important cause of nosocomial infections, particularly in patients in the intensive care units. As chronic infections are difficult to treat, attempts have been made to discover new antimicrobials. Ceragenins, designed to mimic the activities of antimicrobial peptides, are a new class of antimicrobial ...
Cagla Bozkurt-Guzel, Paul B. Savage, Alper Akcali, Berna Ozbek-Celik, Ketoki Kapila   +4 more
wiley   +1 more source

Ceragenin‐Loaded Tri‐Layered Skin Substitute Composed of Natural and Synthetic Biopolymers for Burn Wound Healing

Journal of Biomedical Materials Research Part A, Volume 114, Issue 6, June 2026.
ABSTRACT Burn wounds present significant clinical challenges due to high infection risk, delayed healing, and extensive tissue damage. The development of biomimetic skin substitutes capable of simultaneously supporting tissue regeneration and preventing infection remains a critical need in burn wound management. In this study, a novel ceragenin (CSA‐44)
Nawal Aljayyousi, Emel Tamahkar Irmak, Esra Karaca, Elif Tümay Özer, Oğuzhan Akgün, Ferda Arı, Aycan Yiğit Çınar, Çağla Bozkurt Güzel, Paul B. Savage, Bilgen Osman   +9 more
wiley   +1 more source

Impact of Lipophilicity‐Tuning on the Antimicrobial Activity of a Series of β‐Face–Expanding Bile Acid Derivatives

BioMed Research International, Volume 2026, Issue 1, 2026.
The increasing prevalence of antimicrobial resistance has stimulated the search for new molecular scaffolds with improved efficacy and selectivity. In this study, five bile acid–derived aminosteroids (AC series) and their corresponding biphenyl‐functionalized derivatives (BIAC series) were synthesized and evaluated against Staphylococcus aureus and ...
Allan Mora Abarca, Luis Rivera-Montero, Kenia Barrantes, Victor H. Soto-Tellini, William J. Zamora, Baisakhi Banerjee   +5 more
wiley   +1 more source

Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms

Advanced Science, Volume 12, Issue 1, January 9, 2025.
Antimicrobial peptides (AMPs) are promising alternatives to conventional treatments for polymicrobial biofilms, which increase pathogen resistance. AMPs disrupt biofilm extracellular matrices and microbial membranes, inhibiting biofilm formation and enhancing antibiotic efficacy. Current research addresses challenges like stability and production costs
Cesar Augusto Roque‐Borda, Laura Maria Duran Gleriani Primo, Kaila Petronila Medina‐Alarcón, Isabella C. Campos, Camila de Fátima Nascimento, Mauro M. S. Saraiva, Angelo Berchieri Junior, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini, João Perdigão, Fernando Rogério Pavan, Fernando Albericio   +11 more
wiley   +1 more source

Tackling catheter‐associated urinary tract infections with next‐generation antimicrobial technologies

Journal of Biomedical Materials Research Part A, Volume 112, Issue 3, Page 312-335, March 2024.
Abstract Urinary catheters and other medical devices associated with the urinary tract such as stents are major contributors to nosocomial urinary tract infections (UTIs) as they provide an access path for pathogens to enter the bladder. Considering that catheter‐associated urinary tract infections (CAUTIs) account for approximately 75% of UTIs and ...
Lina Duque‐Sanchez, Yue Qu, Nicolas H. Voelcker, Helmut Thissen   +3 more
wiley   +1 more source

Antibacterial Plasma Polymer Coatings on 3D Materials for Orthopedic Applications

Advanced Materials Interfaces, Volume 11, Issue 2, January 16, 2024.
A plasma‐based technology to create anti‐infection bone implants is introduced. It enables the creation of robust coatings rich in radicals, facilitating strong attachment of antimicrobial agents through covalent bonding. The solvent‐free biofunctionalization, tailored for 3D materials, streamlines functional biomaterial fabrication.
Aiken Dao, Christale Gaitanos, Sumedh Kamble, Omid Sharifahmadian, Richard Tan, Steven G. Wise, Tiffany Lai Yun Cheung, Marcela M.M. Bilek, Paul B. Savage, Aaron Schindeler, Behnam Akhavan   +10 more
wiley   +1 more source

Ceragenin Mediated Selectivity of Antimicrobial Silver Nanoparticles

, 2016
The understanding that common broad-spectrum antimicrobials disrupt natural microbial flora important in acquiring nutrients and preventing infection has resulted in a paradigm shift favoring more selective antimicrobials.
Randolph S. Duran (1758811), Christopher B. Sylvester (1758808), Ammar T. Qureshi (1758817), Paul B. Savage (178014), Mark A. Hoppens (1758802), Thomas Scherr (1758805), Daniel Hayes (1494460), Desiree R. Czapski (1758814)   +7 more
core   +1 more source

Insights into the chemical basis for the impact of ceragenin and derivative compounds on the mechanical performance of medical adhesive formulations

Discover Applied Sciences
An approach to reducing and preventing surgical site infections (SSI) is to incorporate an antimicrobial compound into the formulation of medical adhesives.
Shane M. Drake, Caleb D. Potter, Aaron L. Zaugg, Melissa N. Lumogdang, Daniel J. Pendleton, Jacob R. Orchard, Paul B. Savage, James E. Patterson   +7 more
doaj   +1 more source

Optimization of Ceragenins for Prevention of Bacterial Colonization of Hydrogel Contact Lenses

Investigative Opthalmology & Visual Science, 2013
We provided contact lens hydrogels with an antibacterial innate immune function using nonpeptide mimics of endogenous antimicrobial peptides.Antimicrobial peptide mimics, ceragenins, were prepared for either covalent attachment to hydrogels or for controlled elution from lenses.
Xiaobo, Gu, Jacob D, Jennings, Jason, Snarr, Vinod, Chaudhary, Jacob E, Pollard, Paul B, Savage   +5 more
openaire   +2 more sources