Results 21 to 30 of about 352 (140)

Bactericidal activity of ceragenin CSA-13, CSA-44 and CSA-131 against bacteria causing bloodstream infections [PDF]

Frontiers in Microbiology
IntroductionThe constantly growing resistance of bacteria causing bloodstream infections and the lack of alternative antibiotics generate the need to develop new therapeutic strategies. In this study, the antibacterial properties of synthetic cholic acid
Angelika Mańkowska, Paulina Paprocka, Łukasz Suprewicz, Agata Lesiak, Kamila Fortunka, Grzegorz Król, Jakub Spałek, Jakub Spałek, Sławomir Okła, Sławomir Okła, Bonita Durnaś, Tamara Daniluk, Ewelina Piktel, Paul B. Savage, Robert Bucki, Robert Bucki   +15 more
doaj   +2 more sources

Ceragenin-Coated Endotracheal Tubes for the Reduction of Ventilator-Associated Pneumonia: A Prospective, Longitudinal, Crossover, Interrupted Time, Implementation Study (CEASE VAP Study) [PDF]

Critical Care Explorations
OBJECTIVE:. To evaluate the impact of Ceragenin-coated endotracheal tubes (CSA ETTs) on the incidence of ventilator-associated pneumonia (VAP) in critically ill adults and assess feasibility of conducting a multicenter study. DESIGN:.
John Muscedere, MD, Patrick A. Norman, MSc, Christine D’Arsigney, MD, Andrew G. Day, MSc, John Gordon Boyd, MD, PhD, Tracy Boyd, MSc, David M. Maslove, MD, MS, Stephanie Sibley, MD, MS, Carrie L. Shorey, PhD   +8 more
doaj   +2 more sources

Investigating the Effectiveness of Ceragenins against Acinetobacter baumannii to Develop New Antimicrobial and Anti-Adhesive Strategies [PDF]

Int J Mol Sci
A growing body of experimental data indicates that ceragenins (CSAs), which mimic the physicochemical properties of the host’s cationic antimicrobial peptide, hold promise for the development of a new group of broad-spectrum antimicrobials.
Piotr Deptuła, Paul B. Savage, Urszula Wnorowska, Tamara Daniluk, Beata Sawczuk, Milena Łuckiewicz, Ewelina Piktel, Maciej Karasiński, Paulina Paprocka, Karol Skłodowski, Robert Bucki, Bonita Durnaś   +11 more
core   +2 more sources

Antimicrobial ceragenins inhibit biofilms and affect mammalian cell viability and migration in vitro [PDF]

FEBS Open Bio, Volume 7, Issue 7, Page 953-967, July 2017., 2017
Antimicrobial peptide mimics have great potential as treatments of infected tissue. We investigated one class of mimics, ceragenins, through measuring their ability to mitigate preformed biofilms and stimulate wound healing in vitro. Many ceragenins showed potent anti‐biofilm activity and stimulation of migration and tube formation in our cell culture ...
Melissa A. Olekson, Tao You, Paul B. Savage, Kai P. Leung   +3 more
wiley   +4 more sources

Bottom-up sono-enzymatic approach to build antimicrobial and antifouling nano-enabled coatings on urinary catheters [PDF]

Nanoscale Adv
In this work, an antifouling and antibacterial nano-enabled coating for urinary catheters was synthesised using a bottom-up sono-enzymatic approach.
Tzanov, Tzanko, Ivanova, Kristina, Savage, Paul, Puertas-Segura, Antonio, Ciardelli, Gianluca, Pérez, Leonardo Martín   +5 more
core   +2 more sources

Magnetic nanoparticles enhance the anticancer activity of cathelicidin LL-37 peptide against colon cancer cells

International Journal of Nanomedicine, 2015
Katarzyna Niemirowicz,1 Izabela Prokop,2 Agnieszka Z Wilczewska,3 Urszula Wnorowska,1 Ewelina Piktel,1 Marzena Wątek,4 Paul B Savage,5 Robert Bucki1,6 1Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok ...
Niemirowicz K, Prokop I, Wilczewska AZ, Wnorowska U, Piktel E, Wątek M, Savage PB, Bucki R   +7 more
doaj   +1 more source

Correction: Bucki et al. Bactericidal Properties of Rod-, Peanut-, and Star-Shaped Gold Nanoparticles Coated with Ceragenin CSA-131 against Multidrug-Resistant Bacterial Strains. Pharmaceutics 2021, 13, 425 [PDF]

Pharmaceutics
In the original publication [...]
Sylwia Joanna Chmielewska, Karol Skłodowski, Joanna Depciuch, Piotr Deptuła, Ewelina Piktel, Krzysztof Fiedoruk, Patrycja Kot, Paulina Paprocka, Kamila Fortunka, Tomasz Wollny, Przemysław Wolak, Magdalena Parlinska-Wojtan, Paul B. Savage, Robert Bucki   +13 more
doaj   +2 more sources

Design, synthesis, antimicrobial activity, stability, and mechanism of action of bioresorbable ceragenins [PDF]

RSC Medicinal Chemistry
Design, synthesis and characterization of bioresorbable ceragenins as potent and broad-spectrum antimicrobial agents.
Shawn Gubler, Aaron Zaugg, Rebekah Yi, Elliot Sherren, Elizabeth Milner, Wesley Conyer, Tate May, Tim Jack, Tanner Heaton, Joel Christopherson, Preston Higbee, Emma Powers, Meg Takara, Anna Linder, Boston Boyack, Fetutasi Pauga, Morgann Salmon, Miriam Thomas, Mariko Shiraki, Shenglou Deng, Paul B. Savage   +20 more
openaire   +4 more sources

Ceragenins Prevent the Development of Murine Vaginal Infection Caused by Gardnerella vaginalis [PDF]

Pharmaceuticals
Background/Objectives: Bacterial vaginosis (BV), an infection caused primarily by Gardnerella vaginalis, is the most prevalent vaginal infection. Although BV is often characterized by an asymptomatic course, it can lead to considerable health complications.
Urszula Wnorowska, Ewelina Piktel, Tamara Daniluk, Paulina Paprocka, Paul B. Savage, Bonita Durnaś, Robert Bucki   +6 more
openaire   +4 more sources

Preparation, Characterization, and Antimicrobial Activities of Ceragenins Incorporated Into Polyvinyl Alcohol/Gelatin/Sodium Alginate‐Based Hydrogels for Treatment of Burn Wounds

Journal of Applied Polymer Science, Volume 142, Issue 27, July 15, 2025.
ABSTRACT Ceragenins are synthetic molecules that mimic antimicrobial peptides (AMPs) in the human immune system. They feature a bile acid‐based structure with appended positively charged groups that disrupt bacterial cell membranes, leading to microbial cell death or inactivation.
Nawal Aljayyousi, Emel Tamahkar Irmak, Elif Tümay Özer, Aycan Yiğit Çınar, Çağla Bozkurt Güzel, Paul B. Savage, Bilgen Osman   +6 more
wiley   +2 more sources