Results 11 to 20 of about 352 (140)

Ceragenins and Ceragenin-Based Core-Shell Nanosystems as New Antibacterial Agents against Gram-Negative Rods Causing Nosocomial Infections [PDF]

Pathogens, 2023
The growing number of infections caused by multidrug-resistant bacterial strains, limited treatment options, multi-species infections, high toxicity of the antibiotics used, and an increase in treatment costs are major challenges for modern medicine.
Maciej Karasiński, Urszula Wnorowska, Bonita Durnaś, Grzegorz Król, Tamara Daniluk, Karol Skłodowski, Katarzyna Głuszek, Ewelina Piktel, Sławomir Okła, Robert Bucki   +9 more
doaj   +5 more sources

Ceragenin-mediated disruption of Pseudomonas aeruginosa biofilms. [PDF]

PLoS ONE
BackgroundMicrobial biofilms, as a hallmark of cystic fibrosis (CF) lung disease and other chronic infections, remain a desirable target for antimicrobial therapy.
Urszula Wnorowska, Dawid Łysik, Ewelina Piktel, Magdalena Zakrzewska, Sławomir Okła, Agata Lesiak, Jakub Spałek, Joanna Mystkowska, Paul B Savage, Paul Janmey, Krzysztof Fiedoruk, Robert Bucki   +11 more
doaj   +7 more sources

Incorporation of Ceragenins into Medical Adhesives and Adhesive Scar Tape to Prevent Microbial Colonization Common in Healthcare-Associated Infections [PDF]

Antibiotics
Background/Objectives: Healthcare-associated infections involving surgical sites, skin trauma, and devices penetrating the skin are a frequent source of increased expense, hospitalization periods, and adverse outcomes.
Aaron Zaugg, Elliot Sherren, Rebekah Yi, Alex Farnsworth, Fetutasi Pauga, Anna Linder, Lauren Kelly, Meg Takara, McKenna Hoather, Sierra Stump, Christine Behunin, Boston Boyack, Morgan Tolley, Kayla Holland, Morgann Salmon, Shenglou Deng, James E. Patterson, Paul B. Savage   +17 more
doaj   +3 more sources

Ceragenin CSA-13 displays high antibacterial efficiency in a mouse model of urinary tract infection [PDF]

Scientific Reports, 2022
Ceragenins (CSAs) are synthetic, lipid-based molecules that display activities of natural antimicrobial peptides. Previous studies demonstrated their high in vitro activity against pathogens causing urinary tract infections (UTIs), but their efficiency ...
Urszula Wnorowska, Ewelina Piktel, Piotr Deptuła, Tomasz Wollny, Grzegorz Król, Katarzyna Głuszek, Bonita Durnaś, Katarzyna Pogoda, Paul B. Savage, Robert Bucki   +9 more
doaj   +2 more sources

Glyoxylate Shunt and Pyruvate-to-Acetoin Shift Are Specific Stress Responses Induced by Colistin and Ceragenin CSA-13 in Enterobacter hormaechei ST89 [PDF]

Microbiology Spectrum, 2023
Ceragenins, including CSA-13, are cationic antimicrobials that target the bacterial cell envelope differently than colistin. However, the molecular basis of their action is not fully understood.
Suhanya V. Prasad, Krzysztof Fiedoruk, Magdalena Zakrzewska, Paul B. Savage, Robert Bucki   +4 more
doaj   +2 more sources

Sporicidal activity of ceragenin CSA-13 against Bacillus subtilis [PDF]

Scientific Reports, 2017
AbstractSpore-forming bacteria are a class of microorganisms that possess the ability to survive in extreme environmental conditions. Morphological features of spores assure their resistance to stress factors such as high temperature, radiation, disinfectants, and drying.
Piktel, Ewelina, Pogoda, Katarzyna, Roman, Maciej, Niemirowicz, Katarzyna, Tokajuk, Grażyna, Marta Wróblewska, Szynaka, Beata, Kwiatek, Wojciech, Savage, Paul, Bucki, Robert   +9 more
openaire   +3 more sources

Bactericidal Activity of Ceragenin in Combination with Ceftazidime, Levofloxacin, Co-Trimoxazole, and Colistin against the Opportunistic Pathogen Stenotrophomonas maltophilia [PDF]

Pathogens, 2022
Background: Stenotrophomonas maltophilia (S. maltophilia) is an emerging opportunistic Gram-negative rod causing nosocomial infections predominantly in immunocompromised patients.
Paulina Paprocka, Angelika Mańkowska, Karol Skłodowski, Grzegorz Król, Tomasz Wollny, Agata Lesiak, Katarzyna Głuszek, Paul B. Savage, Bonita Durnaś, Robert Bucki   +9 more
doaj   +2 more sources

Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms [PDF]

mBio, 2020
The development of novel antibiotics is essential because the current arsenal of antimicrobials will soon be ineffective due to the widespread occurrence of antibiotic resistance. The development of naturally occurring cationic antimicrobial peptides (CAMPs) for therapeutics to combat antibiotic resistance has been hampered by high production costs and
Gabriel Mitchell, Melanie R. Silvis, Kelsey C. Talkington, Jonathan M. Budzik, Claire E. Dodd, Justin M. Paluba, Erika A. Oki, Kristine L. Trotta, Daniel J. Licht, David Jimenez-Morales, Seemay Chou, Paul B. Savage, Carol A. Gross, Michael A. Marletta, Jeffery S. Cox   +14 more
openaire   +7 more sources

Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13

Scientific Reports, 2017
Fungal infections caused by Candida spp. represent an emerging problem during treatment of immunocompromised patients and those hospitalized with serious principal diseases.
Katarzyna Niemirowicz, Bonita Durnaś, Grażyna Tokajuk, Ewelina Piktel, Grzegorz Michalak, Xiaobo Gu, Alina Kułakowska, Paul B. Savage, Robert Bucki   +8 more
doaj   +2 more sources

Ceragenins in Combination with Ivacaftor Prevent the Formation of Biofilm by Bacteria That Cause Rhinosinusitis [PDF]

Pharmaceutics
Background/Objectives: Ceragenins (CSAs) maintain strong antibacterial activity even in cystic fibrosis (CF) sputum. Ivacaftor (IVA), a CF transmembrane regulator modulator, provides significant clinical benefits in CF therapy. Based on these properties, we hypothesized that the combination of CSAs and IVA, due to their antibacterial and biofilm ...
Szczepan Kaliniak, Piotr Deptuła, Jakub Spałek, Mariusz Sawieljew, Sylwia Chmielewska-Deptuła, Tamara Daniluk, Agata Lesiak, Bonita Durnaś, Paul B. Savage, Ewelina Piktel, Robert Bucki, Sławomir Okła   +11 more
openaire   +3 more sources