Results 31 to 40 of about 82,164 (300)

Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes

Journal of Lipid Research, 2018
We reported that amyloid β peptide (Aβ42) activated neutral SMase 2 (nSMase2), thereby increasing the concentration of the sphingolipid ceramide in astrocytes.
Ji-Na Kong, Zhihui Zhu, Yutaka Itokazu, Guanghu Wang, Michael B. Dinkins, Liansheng Zhong, Hsuan-Pei Lin, Ahmed Elsherbini, Silvia Leanhart, Xue Jiang, Haiyan Qin, Wenbo Zhi, Stefka D. Spassieva, Erhard Bieberich   +13 more
doaj   +1 more source

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

Molecular Metabolism, 2019
Objective Ectopic fat deposition is associated with increased tissue production of ceramides. Recent genetic mouse studies suggest that specific sphingolipid C16:0 ceramide produced by ceramide synthase 6 (CerS6) plays an important role in the ...
Suryaprakash Raichur, Bodo Brunner, M. Bielohuby, G. Hansen, A. Pfenninger, B. Wang, J. Bruning, P. J. Larsen, N. Tennagels   +8 more
semanticscholar   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Turnover of endogenous ceramide in cultured normal and Farber fibroblasts

Journal of Lipid Research, 1997
De novo synthesis and turnover of endogenous ceramide in cultured skin fibroblasts from patients affected with Farber lipogranulomatosis were studied by biosynthetical labeling of cellular sphingolipids with [14C]serine.
G van Echten-Deckert, A Klein, T Linke, T Heinemann, J Weisgerber, K Sandhoff   +5 more
doaj   +1 more source

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance.

Cell Reports, 2019
Skeletal muscle accumulates ceramides in obesity, which contribute to the development of obesity-associated insulin resistance. However, it remained unclear which distinct ceramide species in this organ contributes to instatement of systemic insulin ...
Sarah M Turpin-Nolan, Philipp Hammerschmidt, WeiYi Chen, A. Jais, K. Timper, M. Awazawa, S. Brodesser, J. Brüning   +7 more
semanticscholar   +1 more source

Ceramide Kinase and Ceramide‐1‐Phosphate

, 2007
It has been over a decade since the sphingolipid ceramide-1-phosphate (C1P) was described. Until recently, only sparse reports on possible biological functions for this lipid have been published. A large number of reports have now surfaced demonstrating distinct biological mechanisms regulated by C1P produced from ceramide kinase (CERK).
Dayanjan S, Wijesinghe, Nadia F, Lamour, Antonio, Gomez-Munoz, Charles E, Chalfant   +3 more
openaire   +3 more sources

Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody

Frontiers in Cell and Developmental Biology, 2019
Ceramide-rich platforms (CRPs) mediate association of proteins with the sphingolipid ceramide and may regulate protein interaction in membrane contact sites to the cytoskeleton, organelles, and infectious pathogens.
Xue Jiang, Xue Jiang, Zhihui Zhu, Haiyan Qin, Priyanka Tripathi, Liansheng Zhong, Liansheng Zhong, Ahmed Elsherbini, Sanjib Karki, Simone M. Crivelli, Wenbo Zhi, Guanghu Wang, Stefanka D. Spassieva, Erhard Bieberich   +13 more
doaj   +1 more source

Ceramide is More Effective than Shea Butter in Maintaining Skin Acidity

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2022
Background: Skin is the largest organ that functions as a physical barrier. Stable skin pH can maximize its function. Ceramide and shea butter cream have components that maintain the skin pH in the stratum corneum. Purpose: The aim is to compare ceramide
Zilpa Widyastuti, Suci Widhiati
doaj   +1 more source

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

Molecular Psychiatry, 2018
Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their action is unknown.
Anne Gulbins, F. Schumacher, K. A. Becker, B. Wilker, Matthias Soddemann, F. Boldrin, C. Müller, M. Edwards, Michael Goodman, C. Caldwell, B. Kleuser, J. Kornhuber, I. Szabó, E. Gulbins   +13 more
semanticscholar   +1 more source