Marked elevations in lung and plasma ceramide in COVID-19 linked to microvascular injury
JCI Insight, 2023 The pathogenesis of the marked pulmonary microvasculature injury, a distinguishing feature of COVID-19 acute respiratory distress syndrome (COVID-ARDS), remains unclear.
Irina Petrache +13 more
doaj +1 more source
Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure. [PDF]
, 2012 Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide.
Bosman, GJ +10 more
core +1 more source
Development and characterization of a novel anti-ceramide antibody
Journal of Lipid Research, 2007 Ceramide is emerging as a key sphingolipid that regulates a variety of cellular processes. To facilitate the study of ceramide localization and its interaction with cellular proteins, we have developed a novel antibody against ceramide.
Kannan Krishnamurthy +2 more
doaj +1 more source
Sphingolipids as emerging mediators in retina degeneration [PDF]
, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber +3 more
core +1 more source
Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase–Mediated Pathway
Journal of Pharmacological Sciences, 2010 .: Ceramide, a key molecule in the metabolism of sphingolipids, is converted by ceramidase to sphingosine, and phosphorylated by ceramide kinase to form ceramide-1-phosphate (C1P). In this study, we improved on a method of thin-layer chromatography using
Eiko Tada +7 more
doaj +1 more source
Doxorubicin Affects Testicular Lipids with Long-Chain (C18-C22) and Very Long-Chain (C24-C32) Polyunsaturated Fatty Acids [PDF]
, 2007 Doxorubicin disrupts spermatogenesis by causing apoptosis of spermatogonia and primary spermatocytes. The aim of this study was to examine the effect of this agent on adult rat testicular lipids and their fatty acids.
Aveldaño, Marta Isabel +2 more
core +1 more source
Ceramide is a Mediator of Apoptosis in Retina Photoreceptors [PDF]
, 2006 PURPOSE. The precise mechanisms involved in photoreceptor apoptosis are still unclear. We here investigated the role of ceramide, a sphingolipid precursor that induces apoptosis upon cellular stress, in activating this death in photoreceptors.
Abrahan, Carolina Elizabeth +3 more
core +1 more source
Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide
Molecular Psychiatry, 2018 Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their action is unknown.
Anne Gulbins +13 more
semanticscholar +1 more source
Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes
Journal of Lipid Research, 2018 We reported that amyloid β peptide (Aβ42) activated neutral SMase 2 (nSMase2), thereby increasing the concentration of the sphingolipid ceramide in astrocytes.
Ji-Na Kong +13 more
doaj +1 more source
Sphingolipids in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma: Ceramide Turnover
International Journal of Molecular Sciences, 2019 Non-alcoholic fatty liver disease (NAFLD) has emerged as one of the main causes of chronic liver disease worldwide. NAFLD comprises a group of conditions characterized by the accumulation of hepatic lipids that can eventually lead to non-alcoholic ...
Jorge Simón +5 more
semanticscholar +1 more source