Results 31 to 40 of about 110,293 (352)

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Turnover of endogenous ceramide in cultured normal and Farber fibroblasts

Journal of Lipid Research, 1997
De novo synthesis and turnover of endogenous ceramide in cultured skin fibroblasts from patients affected with Farber lipogranulomatosis were studied by biosynthetical labeling of cellular sphingolipids with [14C]serine.
G van Echten-Deckert, A Klein, T Linke, T Heinemann, J Weisgerber, K Sandhoff   +5 more
doaj   +1 more source

Mammalian ceramide synthases [PDF]

IUBMB Life, 2010
AbstractIn mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common biochemical features between the CerS, such as their catalytic mechanism, and ...
Michal, Levy, Anthony H, Futerman
openaire   +2 more sources

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations [PDF]

, 2009
Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several diseases, with diverse neurological, psychiatric, and metabolic consequences.
A Caspi, A Schulz, A. CecileJ.W. Janssens, Aaron Isaacs, AE Bielawska, Alan Wright, Anatoly V. Kirichenko, Andrew A. Hicks, Annette Peters, AR Morgan, Ayse Demirkan, B Devlin, Ben A. Oostra, C Gieger, C Pattaro, Caroline Hayward, Carsten Gnewuch, Christian Hengstenberg, Christine Schwienbacher, Christopher S. Franklin, Cornelia M. van Duijn, Cristian Pattaro, E Wang, F Dudbridge, Fabio Marroni, G Liebisch, G Liebisch, Gerd Schmitz, Gerhard Liebisch, Ghazal Zaboli, Greg Gibson, H.-Erich Wichmann, Harry Campbell, Heribert Schunkert, I Rudan, Igor Rudan, Inger Jonasson, Inke R. König, Irene Pichler, Irina V. Zorkoltseva, Ivana Kolcic, J Bras, J Erdmann, Jacqueline C. M. Witteman, James F. Wilson, Jeanette Erdmann, JL Dawkins, KJ Brookes, L Schaeffer, LN Clark, M Mehrabian, MA Simpson, N Amin, N Martinelli, Nick Hastie, NJ Samani, Ozren Polasek, P Wiesner, Peter P. Pramstaller, Peter Ugocsai, S Flamant, S Kathiresan, S Narayan, Sarah H. Wild, SL Schissel, ST Pruett, Stefan Schreiber, Susan Campbell, T Kolter, T Tanaka, Tatiana I. Axenovich, Thomas Meitinger, Ulf Gyllensten, V Vitart, Veronique Vitart, W Zheng, WC Nichols, Wilmar Igl, WL Holland, WM Chen, YS Aulchenko, YS Aulchenko, Yurii Aulchenko, Zrinka Biloglav, Åsa Johansson   +84 more
core   +9 more sources

Ceramide Kinase and Ceramide‐1‐Phosphate

, 2007
It has been over a decade since the sphingolipid ceramide-1-phosphate (C1P) was described. Until recently, only sparse reports on possible biological functions for this lipid have been published. A large number of reports have now surfaced demonstrating distinct biological mechanisms regulated by C1P produced from ceramide kinase (CERK).
Dayanjan S, Wijesinghe, Nadia F, Lamour, Antonio, Gomez-Munoz, Charles E, Chalfant   +3 more
openaire   +3 more sources

Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody

Frontiers in Cell and Developmental Biology, 2019
Ceramide-rich platforms (CRPs) mediate association of proteins with the sphingolipid ceramide and may regulate protein interaction in membrane contact sites to the cytoskeleton, organelles, and infectious pathogens.
Xue Jiang, Xue Jiang, Zhihui Zhu, Haiyan Qin, Priyanka Tripathi, Liansheng Zhong, Liansheng Zhong, Ahmed Elsherbini, Sanjib Karki, Simone M. Crivelli, Wenbo Zhi, Guanghu Wang, Stefanka D. Spassieva, Erhard Bieberich   +13 more
doaj   +1 more source

Ceramide is More Effective than Shea Butter in Maintaining Skin Acidity

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2022
Background: Skin is the largest organ that functions as a physical barrier. Stable skin pH can maximize its function. Ceramide and shea butter cream have components that maintain the skin pH in the stratum corneum. Purpose: The aim is to compare ceramide
Zilpa Widyastuti, Suci Widhiati
doaj   +1 more source

The low intestinal and hepatic toxicity of hydrolyzed fumonisin B1 correlates with its inability to alter the metabolism of sphingolipids [PDF]

, 2012
Fumonisins are mycotoxins frequently found as natural contaminants in maize, where they are produced by the plant pathogen Fusarium verticillioides. They are toxic to animals and exert their effects through mechanisms involving disruption of sphingolipid
Bracarense, Ana-Paula, Cossalter, Anne-Marie, Grenier, Bertrand, Kolf-Clauw, Martine, Moll, Wulf-Dieter, Oswald, Isabelle P, Schatzmayr, Gerd, Schwartz, Heidi-Elisabeth, Trumel, Catherine   +8 more
core   +2 more sources

Open field study of some Zea mays hybrids, lipid compounds and fumonisins accumulation [PDF]

, 2015
Lipid molecules are increasingly recognized as signals exchanged by organisms interacting in pathogenic and/or symbiotic ways. Some classes of lipids actively determine the fate of the interactions.
Battilani, Paola, Cirlini, Martin, Dall’Asta, Chiara, Fanelli, Corrado, Galaverna, Gianni, Giorni, Paola, Ludovici, Matteo, Reverberi, Massimo, Scala, Valeria   +8 more
core   +2 more sources

Detergent-Resistant, Ceramide-Enriched Domains in Sphingomyelin/Ceramide Bilayers [PDF]

Biophysical Journal, 2006
When cell membranes are treated with Triton X-100 or other detergents at 4 degrees C, a nonsolubilized fraction can often be recovered, the "detergent-resistant membranes", that is not found when detergent treatment takes place at 37 degrees C. Detergent-resistant membranes may be related in some cases to membrane "rafts".
Sot, Jesus, Bagatolli, Luis, Goñi, Felix Maria, Alonso, Alicia   +3 more
openaire   +5 more sources