Results 231 to 240 of about 34,100 (243)

Weak electric current increases ceramide levels by inducing ceramide synthase expression

Journal of Asian Association of Schools of Pharmacy
We previously demonstrated that weak electric current (WEC) induces the skin penetration of macromolecules by the cleavage of intercellular junctions and allows for incorporation of macromolecules into cells via endocytosis. We further showed that WEC facilitates the leakage of macromolecules from endosomes to cytoplasm and that this phenomenon ...
Naoshi Yamazaki, Chiho Ohtsuka, Kentaro Kogure   +2 more
openaire   +1 more source

Ceramide Synthases: Roles in Cell Physiology and Signaling

2010
Ceramide synthases (CerS) are integral membrane proteins of the endoplasmic reticulum. Six mammalian CerS have been described, with each utilizing fatty acyl CoAs of relatively defined chain lengths for N-acylation of the sphingoid long chain base. In this chapter, we review the main functional features of the CerS proteins, discuss their fatty acid ...
Johnny, Stiban, Rotem, Tidhar, Anthony H, Futerman   +2 more
openaire   +2 more sources

GalCer Synthase (Ceramide Galactosyltransferase, CGT)

2002
The multilayer membrane system of myelin ensheathing axons of the central nervous system (CNS) and the peripheral nervous system (PNS) is synthesized and assembled by oligodendrocytes and Schwann cells, respectively. The lipid bilayer contributes approximately 70% to 85% of the total myelin mass. The lipid composition is characterized by a high content
openaire   +1 more source

Mechanism of ceramide synthase inhibition by fumonisin B1

Structure
Ceramide synthases (CerSs) play crucial roles in sphingolipid metabolism and have emerged as promising drug targets for metabolic diseases, cancers, and antifungal therapy. However, the therapeutic targeting of CerSs has been hindered by a limited understanding of their inhibition mechanisms by small molecules.
Zike Zhang, Qi Fang, Tian Xie, Xin Gong
openaire   +2 more sources

Ceramide Synthase 2 Interacts with Ceramide Synthases 5 and 6 at the mRNA and Protein Levels

2020
VCU Theses and ...
openaire   +1 more source

Ceramide Synthase

2006
Irene Pankova-Kholmyansky, Anthony H. Futerman   +1 more
openaire   +1 more source

Towards Understanding Regulation of Energy Homeostasis by Ceramide Synthases

2010
Energy homeostasis and growth require the coordinated regulation of lipid metabolism. The underlying molecular mechanisms are poorly understood. We are interested in identifying key regulators of lipid homeostasis and their functional mechanism. Recently, we identified the schlank gene as a major regulator of lipid homeostasis in Drosophila.
openaire   +2 more sources

Measurement of Ceramide Synthase Activity

2000
R, Bose, R, Kolesnick
openaire   +2 more sources

Ceramide synthase.

Methods in enzymology, 1999
E, Wang, A H, Merrill
openaire   +1 more source

WITHDRAWN: Ceramide synthases in cancer therapy and chemoresistance

Progress in Lipid Research, 2019
Sebastian, Brachtendorf, Khadija, El-Hindi, Sabine, Grösch   +2 more
openaire   +2 more sources