Results 211 to 220 of about 338,348 (241)

Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression.

Cell Metabolism
Ceramide metabolism dysregulation links to colorectal cancer (CRC) progression, yet the mechanism remains unknown. d18:1/26:0 ceramide (C26) levels were elevated in patients with CRC and mouse models, which activated epidermal growth factor receptor ...
R. Qu, Yi Zhang, Bora Kim, Guangyi Zeng, Pengcheng Wang, Weike Shaoyong, Ying Huang, Wanwan Guo, Yang Chen, Ping Wang, Qing Yang, Siyi Lu, Xin Zhou, Jing Weng, Jinkun Xu, Jun Lin, Kai Wang, Yanpeng Ma, Shogo Takahashi, Yuhong Luo, Xiaoting Yu, K. Krausz, Yanli Pang, Tianpei Hong, Zhipeng Zhang, Wei Fu, Frank J. Gonzalez, Lulu Sun   +27 more
semanticscholar   +1 more source

Ceramide synthases in cancer therapy and chemoresistance

Progress in Lipid Research, 2019
Drug resistance is one major reason for failure of cancer therapy. In the past 10 years, evidence emerged showing that ceramides of specific chain length, generated by six different ceramide synthases (CerS), are deregulated in different cancer types thereby influencing chemosensitivity.
Sebastian, Brachtendorf, Khadija, El-Hindi, Sabine, Grösch   +2 more
openaire   +2 more sources

Ceramide Synthases: Reexamining Longevity

2013
The ceramide synthase (CerS) enzymes catalyze the formation of (dihydro) ceramide, and thereby provide critical complexity to all sphingolipids (SLs) with respect to their acyl chain length. This review summarizes the progress in the field of CerS from the time of their discovery more than a decade ago as Longevity assurance (Lass) genes in yeast ...
Joo-Won, Park, Yael, Pewzner-Jung
openaire   +2 more sources

The Role of the Ceramide Acyl Chain Length in Neurodegeneration: Involvement of Ceramide Synthases

NeuroMolecular Medicine, 2010
Ceramide forms the backbone of all complex sphingolipids and has been the focus of considerable attention in the past few years due to the discovery that ceramide plays vital roles as an intracellular messenger. Ceramide, which consists of a sphingoid long chain base to which a fatty acid is N-acylated, is synthesized in mammals by a family of ceramide
Oshrit, Ben-David, Anthony H, Futerman
openaire   +2 more sources

Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy.

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2018
Resistance against chemotherapy is a life-threatening complication in colon cancer therapy. To increase response rate, new additional targets that contribute to chemoresistance are still needed to be explored.
Sebastian Brachtendorf, R. Wanger, Kerstin Birod, Dominique Thomas, S. Trautmann, Marthe-Susanna Wegner, D. Fuhrmann, B. Brüne, G. Geisslinger, S. Grösch   +9 more
semanticscholar   +1 more source

[3] Ceramide synthase

2000
Publisher Summary Ceramide synthase catalyzes the acylation of sphinganine, sphingosine, and other long chain sphingoid bases to form their N-acyl derivatives, which are usually referred to as “dihydroceramides” (N-acylsphinganines) and “ceramides” (N-acylsphingosines).
Elaine Wang, Alfred H. Merrill
openaire   +1 more source

Fluorescent Assays for Ceramide Synthase Activity

2016
Ceramides are the central lipid metabolite of the sphingolipid family, and exert a potent influence over cell polarity, differentiation, and survival through their biophysical properties and their specific interactions with cell signaling proteins. Literature on the importance of ceramides in physiology and pathological conditions continues to grow ...
Timothy A, Couttas, Anthony S, Don
openaire   +2 more sources

Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division.

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2018
The replacement of two consecutive histidine residues by alanine residues in the catalytic center of ceramide synthase 2 in a new transgenic mouse mutant (CerS2 H/A) leads to inactivation of catalytic activity and reduces protein level to 60% of the WT ...
Andreas Bickert, P. Kern, M. van Uelft, S. Herresthal, T. Ulas, K. Gutbrod, Bernadette Breiden, Joachim Degen, K. Sandhoff, J. Schultze, P. Dörmann, D. Hartmann, R. Bauer, K. Willecke   +13 more
semanticscholar   +1 more source

Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer

Journal of Cancer Research and Clinical Oncology, 2009
Sphingolipids are bioactive lipids implicated in apoptosis, cell survival and proliferation. We analyzed the prognostic value of enzymes from sphingolipid metabolism in breast cancer.Differences in expression of ceramide galactosyl transferase (UGT8), ceramide kinase (CERK), and Ganglioside GD3-Synthase (ST8SIA1) in breast cancer cells were ...
Eugen, Ruckhäberle, Thomas, Karn, Achim, Rody, Lars, Hanker, Regine, Gätje, Dirk, Metzler, Uwe, Holtrich, Manfred, Kaufmann   +7 more
openaire   +2 more sources

Ceramide Synthase 2 Interacts with Ceramide Synthases 5 and 6 at the mRNA and Protein Levels

2020
VCU Theses and ...
openaire   +1 more source