Results 201 to 210 of about 338,348 (241)
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Structure of the yeast ceramide synthase
Nature Structural & Molecular Biology, 2023Ceramides are essential lipids involved in forming complex sphingolipids and acting as signaling molecules. They result from the N-acylation of a sphingoid base and a CoA-activated fatty acid, a reaction catalyzed by the ceramide synthase (CerS) family of enzymes.
Jan-Hannes Schäfer +8 more
semanticscholar +4 more sources
Induction of glucosylceramide synthase by synthase inhibitors and ceramide
Lipids and Lipid Metabolism, 1996Glucosylceramide (GlcCer) synthase acts on the sphingolipid, ceramide, to transer a glucose moiety from UDP-glc, thus forming the first member of a large family of glucosphingolipids. Two inhibitors of the enzyme, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-threo-PDMP) and N-butyldeoxynojirimycin (NBDN), have been found to induce an ...
Norman S Radin, James A Shayman
exaly +3 more sources
Mechanism of ceramide synthase inhibition by fumonisin B1.
StructureCeramide synthases (CerSs) play crucial roles in sphingolipid metabolism and have emerged as promising drug targets for metabolic diseases, cancers, and antifungal therapy.
Zike Zhang +3 more
semanticscholar +3 more sources
The enigma of ceramide synthase regulation in mammalian cells.
Progress in Lipid Research, 2016Ceramide synthases (CerS) are key enzymes in the lipid metabolism of eukaryotic cells. Their products, ceramides (Cer), are components of cellular membranes but also mediate signaling functions in physiological processes such as proliferation, skin barrier function and cerebellar development.
Marthe-Susanna Wegner +4 more
semanticscholar +3 more sources
Disruption of the ceramide synthase LOH1 causes spontaneous cell death inArabidopsis thaliana
New Phytologist, 2011 ceramide, ceramide synthase ...
Philipp Ternes +2 more
exaly +2 more sources
Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson's disease
Movement Disorders, 2014 Genetic studies have provided increasing evidence that ceramide homeostasis plays a role in neurodegenerative diseases including Parkinson's disease (PD).
Hongyun Li +2 more
exaly +1 more source
Embryonic expression of Drosophila ceramide synthase schlank in developing gut, CNS and PNS
Gene Expression Patterns, 2011 Schlank is a member of the highly conserved ceramide synthase family and controls growth and body fat in Drosophila. Ceramide synthases are key enzymes in the sphingolipid de novo synthesis pathway.
André Voelzmann, Reinhard Bauer
exaly +2 more sources
Ceramide synthases in biomedical research
Chemistry and Physics of Lipids, 2016Sphingolipid metabolism consists of multiple metabolic pathways that converge upon ceramide, one of the key molecules among sphingolipids (SLs). In mammals, ceramide synthesis occurs via N-acylation of sphingoid backbones, dihydrosphingosine (dhSo) or sphingosine (So). The reaction is catalyzed by ceramide synthases (CerS), a family of enzymes with six
Francesca, Cingolani +2 more
openaire +2 more sources