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Ceramide Synthases: Roles in Cell Physiology and Signaling
2010Ceramide synthases (CerS) are integral membrane proteins of the endoplasmic reticulum. Six mammalian CerS have been described, with each utilizing fatty acyl CoAs of relatively defined chain lengths for N-acylation of the sphingoid long chain base. In this chapter, we review the main functional features of the CerS proteins, discuss their fatty acid ...
Johnny, Stiban +2 more
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Weak electric current increases ceramide levels by inducing ceramide synthase expression
Journal of Asian Association of Schools of PharmacyWe previously demonstrated that weak electric current (WEC) induces the skin penetration of macromolecules by the cleavage of intercellular junctions and allows for incorporation of macromolecules into cells via endocytosis. We further showed that WEC facilitates the leakage of macromolecules from endosomes to cytoplasm and that this phenomenon ...
Naoshi Yamazaki +2 more
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GalCer Synthase (Ceramide Galactosyltransferase, CGT)
2002The multilayer membrane system of myelin ensheathing axons of the central nervous system (CNS) and the peripheral nervous system (PNS) is synthesized and assembled by oligodendrocytes and Schwann cells, respectively. The lipid bilayer contributes approximately 70% to 85% of the total myelin mass. The lipid composition is characterized by a high content
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WITHDRAWN: Ceramide synthases in cancer therapy and chemoresistance
Progress in Lipid Research, 2019Sebastian, Brachtendorf +2 more
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Ceramide synthase 4 is highly expressed in involved skin of patients with atopic dermatitis
Journal of the European Academy of Dermatology and Venereology, 2017Shotaro Ito +7 more
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