Results 221 to 230 of about 34,100 (243)

Ceramide Synthases: Reexamining Longevity

2013
The ceramide synthase (CerS) enzymes catalyze the formation of (dihydro) ceramide, and thereby provide critical complexity to all sphingolipids (SLs) with respect to their acyl chain length. This review summarizes the progress in the field of CerS from the time of their discovery more than a decade ago as Longevity assurance (Lass) genes in yeast ...
Joo-Won, Park, Yael, Pewzner-Jung
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Induction of glucosylceramide synthase by synthase inhibitors and ceramide

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1996
Glucosylceramide (GlcCer) synthase acts on the sphingolipid, ceramide, to transer a glucose moiety from UDP-glc, thus forming the first member of a large family of glucosphingolipids. Two inhibitors of the enzyme, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-threo-PDMP) and N-butyldeoxynojirimycin (NBDN), have been found to induce an ...
A, Abe, N S, Radin, J A, Shayman
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[3] Ceramide synthase

2000
Publisher Summary Ceramide synthase catalyzes the acylation of sphinganine, sphingosine, and other long chain sphingoid bases to form their N-acyl derivatives, which are usually referred to as “dihydroceramides” (N-acylsphinganines) and “ceramides” (N-acylsphingosines).
Elaine Wang, Alfred H. Merrill
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Fluorescent Assays for Ceramide Synthase Activity

2016
Ceramides are the central lipid metabolite of the sphingolipid family, and exert a potent influence over cell polarity, differentiation, and survival through their biophysical properties and their specific interactions with cell signaling proteins. Literature on the importance of ceramides in physiology and pathological conditions continues to grow ...
Timothy A, Couttas, Anthony S, Don
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Ceramide synthases in cancer therapy and chemoresistance

Progress in Lipid Research, 2019
Drug resistance is one major reason for failure of cancer therapy. In the past 10 years, evidence emerged showing that ceramides of specific chain length, generated by six different ceramide synthases (CerS), are deregulated in different cancer types thereby influencing chemosensitivity.
Sebastian, Brachtendorf, Khadija, El-Hindi, Sabine, Grösch   +2 more
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Structure of the yeast ceramide synthase

Nature Structural & Molecular Biology
Ceramides are essential lipids involved in forming complex sphingolipids and acting as signaling molecules. They result from the N-acylation of a sphingoid base and a CoA-activated fatty acid, a reaction catalyzed by the ceramide synthase (CerS) family of enzymes.
Jan-Hannes Schäfer, Lena Clausmeyer, Carolin Körner, Bianca M. Esch, Verena N. Wolf, Jennifer Sapia, Yara Ahmed, Stefan Walter, Stefano Vanni, Dovile Januliene, Arne Moeller, Florian Fröhlich   +11 more
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Structure of the yeast ceramide synthase

2023
AbstractCeramides play a pivotal role as essential lipids, serving as foundational components for complex sphingolipids and potent signaling molecules. Ceramides are the products of the N-acylation of a sphingoid base and a CoA-activated fatty acid.
Jan-Hannes Schäfer, Lena Clausmeyer, Carolin Körner, Bianca M. Esch, Verena N. Wolf, Stefan Walter, Dovile Januliene, Arne Moeller, Florian Fröhlich   +8 more
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The Role of the Ceramide Acyl Chain Length in Neurodegeneration: Involvement of Ceramide Synthases

NeuroMolecular Medicine, 2010
Ceramide forms the backbone of all complex sphingolipids and has been the focus of considerable attention in the past few years due to the discovery that ceramide plays vital roles as an intracellular messenger. Ceramide, which consists of a sphingoid long chain base to which a fatty acid is N-acylated, is synthesized in mammals by a family of ceramide
Oshrit, Ben-David, Anthony H, Futerman
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Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer

Journal of Cancer Research and Clinical Oncology, 2009
Sphingolipids are bioactive lipids implicated in apoptosis, cell survival and proliferation. We analyzed the prognostic value of enzymes from sphingolipid metabolism in breast cancer.Differences in expression of ceramide galactosyl transferase (UGT8), ceramide kinase (CERK), and Ganglioside GD3-Synthase (ST8SIA1) in breast cancer cells were ...
Eugen, Ruckhäberle, Thomas, Karn, Achim, Rody, Lars, Hanker, Regine, Gätje, Dirk, Metzler, Uwe, Holtrich, Manfred, Kaufmann   +7 more
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Regulation of (di‐hydro) ceramide synthase 1

The FASEB Journal, 2008
The mammalian (di‐hydro) ceramide synthases (CerS) are a family of 6 genes, previously referred to as l ongevity ass urance (LASS) genes based on their function in yeast.
Priya Sridevi, Hannah Alexander, Elad Laviad, Mark Hannink, Anthony Futerman, Stephen Alexander   +5 more
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