Results 1 to 10 of about 848,065 (307)

Drought and heat stress mediated activation of lipid signaling in plants: a critical review [PDF]

Frontiers in Plant Science, 2023
Lipids are a principal component of plasma membrane, acting as a protective barrier between the cell and its surroundings. Abiotic stresses such as drought and temperature induce various lipid-dependent signaling responses, and the membrane lipids ...
Parul Sharma, Nita Lakra, Alisha Goyal, Yogesh K. Ahlawat, Yogesh K. Ahlawat, Abbu Zaid, Abbu Zaid, Kadambot H. M. Siddique   +7 more
doaj   +2 more sources

Raman microscopy-based quantification of the physical properties of intracellular lipids

Communications Biology, 2021
Uematsu and Shimizu use Raman spectroscopy to quantify changes in the physical properties of lipid droplets (LDs) and in non-LD cell regions associated with alterations in saturated and unsaturated fatty acid availability in culture medium. Their results
Masaaki Uematsu, Takao Shimizu
doaj   +1 more source

Lipidomic Analyses Reveal Specific Alterations of Phosphatidylcholine in Dystrophic Mdx Muscle

Frontiers in Physiology, 2022
In Duchenne muscular dystrophy (DMD), lack of dystrophin increases the permeability of myofiber plasma membranes to ions and larger macromolecules, disrupting calcium signaling and leading to progressive muscle wasting. Although the biological origin and
William J. Valentine, William J. Valentine, Sherif A. Mostafa, Sherif A. Mostafa, Suzumi M. Tokuoka, Fumie Hamano, Fumie Hamano, Natsuko F. Inagaki, Joel Z. Nordin, Joel Z. Nordin, Norio Motohashi, Yoshihiro Kita, Yoshitsugu Aoki, Takao Shimizu, Hideo Shindou, Hideo Shindou   +15 more
doaj   +1 more source

Drug Repositioning for the Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy: A Mechanism- and Screening-Based Strategy

Frontiers in Pharmacology, 2021
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe adverse effect observed in most patients treated with neurotoxic anti-cancer drugs. Currently, there are no therapeutic options available for the prevention of CIPN. Furthermore, few drugs are
Shota Yamamoto, Nobuaki Egashira
doaj   +1 more source

Profiling of fatty acid metabolism in the dorsal root ganglion after peripheral nerve injury

Frontiers in Pain Research, 2022
Peripheral nerve injury (PNI) induces neuronal hyperexcitability, which underlies neuropathic pain. The emergence of RNA sequencing technologies has enabled profiling of transcriptional changes in pathological conditions. However, these approaches do not
Shota Yamamoto, Tomomi Hashidate-Yoshida, Takao Shimizu, Takao Shimizu, Hideo Shindou, Hideo Shindou   +5 more
doaj   +1 more source

Hepatic Levels of DHA-Containing Phospholipids Instruct SREBP1-Mediated Synthesis and Systemic Delivery of Polyunsaturated Fatty Acids

iScience, 2020
Summary: Polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and arachidonic acid (ARA), play fundamental roles in mammalian physiology.
Daisuke Hishikawa, Keisuke Yanagida, Katsuyuki Nagata, Ayumi Kanatani, Yoshiko Iizuka, Fumie Hamano, Megumi Yasuda, Tadashi Okamura, Hideo Shindou, Takao Shimizu   +9 more
doaj   +1 more source

Maternal Transmission of Human OGG1 Protects Mice Against Genetically- and Diet-Induced Obesity Through Increased Tissue Mitochondrial Content

Frontiers in Cell and Developmental Biology, 2021
Obesity and related metabolic disorders are pressing public health concerns, raising the risk for a multitude of chronic diseases. Obesity is multi-factorial disease, with both diet and lifestyle, as well as genetic and developmental factors leading to ...
Natalie Burchat, Priyanka Sharma, Hong Ye, Sai Santosh Babu Komakula, Sai Santosh Babu Komakula, Agnieszka Dobrzyn, Agnieszka Dobrzyn, Vladimir Vartanian, R. Stephen Lloyd, R. Stephen Lloyd, Harini Sampath, Harini Sampath, Harini Sampath   +12 more
doaj   +1 more source

Quantification of Fatty Acids in Mammalian Tissues by Gas Chromatography–Hydrogen Flame Ionization Detection

Bio-Protocol, 2020
In mammalian organisms, fatty acids (FAs) exist mostly in esterified forms, as building blocks of phospholipids, triglycerides, and cholesteryl esters, while some exist as non-esterified free FAs. The absolute quantification of FA species in total lipids
Fumie Hamano, Suzumi Tokuoka, Tomomi Hashidate-Yoshida, Hideo Shindou, Takao Shimizu, Yoshihiro Kita   +5 more
doaj   +1 more source

Comparative Analysis of Phospholipase D (PLD) Gene Family in Camelina sativa and Brassica napus and Its Responses in Camelina Seedlings under Salt Stress

Agronomy, 2023
Phospholipases are among the important elements involved in lipid-dependent cell signaling that lead to the induction of downstream pathways. In the current study, phospholipases D (PLDs) gene family was characterized and compared in two important ...
Parviz Heidari, Fatemeh Puresmaeli, Yavar Vafaee, Mostafa Ahmadizadeh, Mohammadreza Ensani, Haniyeh Ahmadinia   +5 more
doaj   +1 more source

Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. [PDF]

, 2017
Disruption of hepatocyte growth hormone (GH) signaling through disruption of Jak2 (JAK2L) leads to fatty liver. Previously, we demonstrated that development of fatty liver depends on adipocyte GH signaling.
Camporez, João Paulo G, Corbit, Kevin C, Deo, Rahul C, Edmunds, Lia R, Erion, Derek M, Jurczak, Michael J, Perry, Rachel J, Shulman, Gerald I, Tran, Jennifer L, Vera, Nicholas B, Weiss, Ethan J   +10 more
core   +1 more source