Results 41 to 50 of about 1,963,371 (292)

The role of extended synaptotagmin at membrane contact sites in cancer research

Frontiers in Cell and Developmental Biology, 2023
Membrane contact sites (MCSs) are adjacent locations between the membranes of two different organelles and play important roles in various physiological processes, including cellular calcium and lipid signaling.
Yuetian Pan, Yuetian Pan, Dorothee Strohmer, Shikai Feng, Guibin Zhang, Hongshang Cui, Yongbin Song   +6 more
doaj   +1 more source

The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes

Journal of Lipid Research, 2019
Phosphoinositides are key regulators of a large number of diverse cellular processes that include membrane trafficking, plasma membrane receptor signaling, cell proliferation, and transcription.
Aby Grabon, Vytas A. Bankaitis, Mark I. McDermott   +2 more
doaj   +1 more source

Salicylic acid modulates levels of phosphoinositide dependent-phospholipase C substrates and products to remodel the Arabidopsis suspension cell transcriptome

Frontiers in Plant Science, 2014
Basal phosphoinositide-dependent phospholipase C (PI-PLC) activity controls gene expression in Arabidopsis suspension cells and seedlings. PI-PLC catalyzes the production of phosphorylated inositol and diacylglycerol (DAG) from phosphoinositides.
Eric eRuelland, Eric eRuelland, Eric eRuelland, Igor ePokotylo, Igor ePokotylo, Catherine eCantrel, Catherine eCantrel, Nabila eDjafi, Anne eRepellin, Alain eZachowski, Alain eZachowski, Alain eZachowski   +11 more
doaj   +1 more source

Nanoparticles and Their Applications in Lipid Signaling. [PDF]

Methods Mol Biol
This chapter provides an overview of the diverse range of applications associated with nanoparticles. The application of nanoparticles in the medical field has garnered considerable attention due to their unique properties and versatile compositions. They have shown promise in the treatment of cancer, fungal and viral infections, and pain management ...
Ashin ZF, Yacoub AS, Saady M, Thompson SE, Awad K, Aswath P, Brotto M, Varanasi V.   +7 more
europepmc   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis. [PDF]

Cell Commun Signal
Background: Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-cell death ...
Sarkar S, Deiter C, Kyle JE, Guney MA, Sarbaugh D, Yin R, Li X, Cui Y, Ramos-Rodriguez M, Nicora CD, Syed F, Juan-Mateu J, Muralidharan C, Pasquali L, Evans-Molina C, Eizirik DL, Webb-Robertson BM, Burnum-Johnson K, Orr G, Laskin J, Metz TO, Mirmira RG, Sussel L, Ansong C, Nakayasu ES.   +24 more
europepmc   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Manipulation of lipid rafts in neuronal cells [PDF]

, 2010
Lipid rafts are specialized plasma membrane micro-domains highly enriched in cholesterol, sphingolipids and glycosylphosphatidylinositol (GPI) anchored proteins.
Eckert, Gunter P.
core  

A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins

eLife, 2020
Yeast Sfh5 is an unusual member of the Sec14-like phosphatidylinositol transfer protein (PITP) family. Whereas PITPs are defined by their abilities to transfer phosphatidylinositol between membranes in vitro, and to stimulate phosphoinositide signaling ...
Danish Khan, Dongju Lee, Gulcin Gulten, Anup Aggarwal, Joshua Wofford, Inna Krieger, Ashutosh Tripathi, John W Patrick, Debra M Eckert, Arthur Laganowsky, James Sacchettini, Paul Lindahl, Vytas A Bankaitis   +12 more
doaj   +1 more source