Results 41 to 50 of about 848,065 (307)
Manipulation of lipid rafts in neuronal cells [PDF]
, 2010 Lipid rafts are specialized plasma membrane micro-domains highly enriched in cholesterol, sphingolipids and glycosylphosphatidylinositol (GPI) anchored proteins.
Eckert, Gunter P.
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Sphingolipids as emerging mediators in retina degeneration [PDF]
, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber +3 more
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Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review [PDF]
, 2020 Background A growing number of epidemiological studies indicate that metabolic syndrome (MetS) and its associated features play a key role in the development of certain degenerative brain disorders, including Alzheimer’s disease and vascular dementia ...
Bell, J.D. +9 more
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Lipid signalling in cardiovascular pathophysiology [PDF]
Cardiovascular Research, 2008 Although the role of lipids in the pathogenesis of cardiovascular disease has been appreciated for several decades, recent studies have advanced our understanding and revealed complex new functions and interactions for lipid molecules that are both beneficial and adverse.
Joel S, Karliner, Joan Heller, Brown
openaire +2 more sources
The role of extended synaptotagmin at membrane contact sites in cancer research
Frontiers in Cell and Developmental Biology, 2023 Membrane contact sites (MCSs) are adjacent locations between the membranes of two different organelles and play important roles in various physiological processes, including cellular calcium and lipid signaling.
Yuetian Pan +6 more
doaj +1 more source
Glycosylphosphatidylinositols: More than just an anchor? [PDF]
, 2016 There is increasing interest in the role of glycosylphosphatidylinositol (GPI) anchors that attach some proteins to cell membranes. Far from being biologically inert, GPIs influence the targeting, intracellular trafficking and function of the attached ...
Bate, C, Nolan, W, Williams, A
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Journal of Lipid Research, 2019 Fumonisins are mycotoxins that cause diseases of plants and, when consumed by animals, can damage liver, kidney, lung, brain, and other organs, alter immune function, and cause developmental defects and cancer.
Ronald T. Riley, Alfred H. Merrill, Jr.
doaj +1 more source
Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]
, 2010 The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt +44 more
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Journal of Lipid Research, 2019 Phosphoinositides are key regulators of a large number of diverse cellular processes that include membrane trafficking, plasma membrane receptor signaling, cell proliferation, and transcription.
Aby Grabon +2 more
doaj +1 more source
Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling. [PDF]
, 2017 Membrane contact sites (MCSs) function to facilitate the formation of membrane domains composed of specialized lipids, proteins, and nucleic acids. In cells, membrane domains regulate membrane dynamics and biochemical and signaling pathways.
Murley, Andrew +6 more
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