Results 61 to 70 of about 1,963,371 (292)

Crosstalk between phospholipase D and sphingosine kinase in plant stress signaling

Frontiers in Plant Science, 2012
The activation of phospholipase D (PLD) produces phosphatidic acid (PA), whereas sphingosine kinase (SPHK) phosphorylates long-chain bases (LCBs) to generate LCB-1-phosphates (LCBPs) such as phytosphingosine-1-phosphate (phyto-S1P). PA and phyto-S1P have
Xuemin eWang
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Acute Myeloid Leukemia: A Key Role of DGKα and DGKζ in Cell Viability

Cells
Acute myeloid leukemia (AML) is a heterogeneous disease with an unmet need for novel therapeutic drugs. Previous studies have reported the upregulation of diacylglycerol kinases (DGKs) in AML.
Elisa Gorla, Marco Cristiano Cartella, Edoardo Borghetti, Ginevra Lovati, Luisa Racca, Teresa Gravina, Giorgio Biazzo, Gabriele Bonello, Valeria Malacarne, Veronica De Giorgis, Davide Corà, Marcello Manfredi, Alberto Massarotti, Andrea Graziani, Gianluca Baldanzi   +14 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton [PDF]

, 1999
CD44, the major cell surface receptor for hyaluronic acid (HA), was shown to localize to detergent-resistant cholesterol-rich microdomains, called lipid rafts, in fibroblasts and blood cells.
Ursula Günthert, Günthert, U., Huber, L. A., Beug, H., Hartmut Beug, Gerke, V., Thomas Harder, Paiha, K., Volker Gerke, Oliferenko, S., Schwarz, H., Karin Paiha, Heinz Schwarz, Harder, T., Snezhana Oliferenko, Lukas A. Huber, Christoph Schwärzler, Schwärzler, C.   +17 more
core   +1 more source

Lipid phosphate phosphatases and signaling

Journal of Lipid Research, 2009
Lipid phosphate phosphatases (LPPs) regulate cell signaling by modifying the concentrations of lipid phosphates versus their dephosphorylated products. The ecto-activity regulates the availability of extracellular lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P) and thereby signaling by their respective receptors.
David N. Brindley, Carlos Pilquil
openaire   +3 more sources

Synaptic lipid signaling

Journal of Lipid Research, 2003
Neuronal cellular and intracellular membranes are rich in specialized phospholipids that are reservoirs of lipid messengers released by specific phospholipases and stimulated by neurotransmitters, neurotrophic factors, cytokines, membrane depolarization,
Nicolas G. Bazan
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Lipid peroxidation is essential for α-synuclein-induced cell death. [PDF]

, 2015
Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease.
Klenerman, D, Shchepinov, MS, Gandhi, S, Angelova, PR, Horrocks, MH, Abramov, AY   +5 more
core  

Stabilization of the cortical cytoskeleton by the lipid raft-associated protein cap23 [PDF]

, 2006
In the present work, we identified the lipid raft-associated protein Cap23 to be involved in several important neuronal functions like the organization of lipid raft platforms, the maturation and stabilization of the actin- and intermediate filament ...
Wacha, Stefan
core   +1 more source