Molecular networks in FGF signaling: Flotillin-1 and Cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2 [PDF]
, 2012 Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases.
Traub Stephanie +11 more
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Regulation of the leading edge motility by PI (4,5)P2-dependent lipid microdomains [PDF]
, 2005 The lipid second messenger PI(4,5)P2 modulates actin dynamics, and its local accumulation at plasmalemmal microdomains (rafts) might mediate regulation of protrusive motility.
Golub, Tamara
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Establishment of LC-MS methods for the analysis of palmitoylated surfactant proteins[S]
Journal of Lipid Research, 2015 The surfactant proteins (SPs), SP-B and SP-C, are important components of pulmonary surfactant involved in the reduction of alveolar surface tension. Quantification of SP-B and SP-C in surfactant drugs is informative for their quality control and the ...
Takeshi Harayama +7 more
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Biomolecules, 2020 Adrenic acid (AA), the 2-carbon elongation product of arachidonic acid, is present at significant levels in membrane phospholipids of mouse peritoneal macrophages.
Patricia Monge +6 more
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Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line [PDF]
, 2010 Includes abstract.Includes bibliographical references (leaves 121-158).A recent study from the Hapgood laboratory demonstrated the presence of a novel crosstalk mechanism between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone ...
Wehmeyer, Lance
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Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2[S]
Journal of Lipid Research, 2014 Platelet-activating factor (PAF) is a potent pro-inflammatory phospholipid mediator. In response to extracellular stimuli, PAF is rapidly biosynthesized by lyso-PAF acetyltransferase (lyso-PAFAT).
Megumi Tarui +10 more
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Lipid metabolism and signaling in cancer
, 2020 Cancer cells frequently display specific alterations in their metabolic activity. Reprogramming of lipid metabolism is now a recognized hallmark of malignancy, and reactivation of fatty acids (FA) and cholesterol biosynthesis is frequently observed in ...
James M. Ntambi +5 more
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Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo
Cell Reports, 2019 Summary: Hematopoietic stem cells (HSCs) maintain lifelong hematopoiesis by remaining quiescent in the bone marrow niche. Recapitulation of a quiescent state in culture has not been achieved, as cells rapidly proliferate and differentiate in vitro. After
Hiroshi Kobayashi +12 more
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Recent Advances in Research on Molecular Mechanisms of Fungal Signaling
Encyclopedia, 2022 Biochemical signaling is one of the key mechanisms to coordinate a living organism in all aspects of its life. It is still enigmatic how exactly cells and organisms deal with environmental signals and irritations precisely because of the limited number ...
Stefan Jacob +2 more
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Journal of Lipid Research, 2019 Fumonisins are mycotoxins that cause diseases of plants and, when consumed by animals, can damage liver, kidney, lung, brain, and other organs, alter immune function, and cause developmental defects and cancer.
Ronald T. Riley, Alfred H. Merrill, Jr.
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