Results 61 to 70 of about 77,401 (305)

Cerebellar Atrophy in Epileptic Patients [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1988
ABSTRACT:High-resolution CT scans of the brain and posterior fossa were performed on 106 phenytoin (PHT)- treated epileptics, 28 de novo epileptics and 43 control subjects. A higher incidence of cerebellar and brainstem (CBS) atrophy was observed in chronic PHT- or PHT+ phenobarbital-treated epileptics compared to the two other groups.
M I, Botez, E, Attig, J L, Vézina
openaire   +2 more sources

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Frequency, characteristics, and immunological accompaniments of ataxia in anti-NMDAR antibody-associated encephalitis

Frontiers in Immunology
IntroductionVery rarely, adult NMDAR antibody-associated encephalitis (NMDAR-E) leads to persistent cerebellar atrophy and ataxia. Transient cerebellar ataxia is common in pediatric NMDAR-E. Immune-mediated cerebellar ataxia may be associated with myelin
Sarah Jesse, Marie Riemann, Hauke Schneider, Marius Ringelstein, Marius Ringelstein, Nico Melzer, Niklas Vogel, Lena Kristina Pfeffer, Manuel A. Friese, Kurt-Wolfram Sühs, Dominica Hudasch, Philipp Schwenkenbecher, Albrecht Günther, Christian Geis, Jonathan Wickel, Martin Lesser, Annika Kather, Frank Leypoldt, Frank Leypoldt, Justina Dargvainiene, Robert Markewitz, Klaus-Peter Wandinger, Franziska S. Thaler, Franziska S. Thaler, Joseph Kuchling, Katharina Wurdack, Lidia Sabater, Lidia Sabater, Carsten Finke, Jan Lewerenz   +29 more
doaj   +1 more source

Structural cerebellar correlates of cognitive functions in spinocerebellar ataxia type 2 [PDF]

, 2018
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease involving the cerebellum and characterized by a typical motor syndrome.
A Durr, A Moriarty, AM Tedesco, AR Giovagnoli, C Brenneis, C Habas, C. Iacobacci, CJ Stoodley, CJ Stoodley, CJ Stoodley, D Milardi, D Wang, E Keren-Happuch, E Storey, EV Evarts, F Pira Le, FA Middleton, FM Krienen, G Allen, G Olivito, G Olivito, G. Olivito, GA Carlesimo, H Spinnler, I Klinke, J Diedrichsen, JA Bernard, JC Raven, JD Schmahmann, JD Schmahmann, JD Schmahmann, JG Borkowsky, JM Kemp, JT Pang, K Bürk, K Iwabuchi, K Kansal, M Dayan, M King, M Monaco, M. Bozzali, M. Cercignani, M. Leggio, M. Lupo, M. Masciullo, M. Molinari, MG Leggio, MP Heuvel van den, P Caffarra, P Trouillas, PM Corsi, R Chopra, R Della Nave, R Estrada, R Fancellu, R Krikorian, RL Buckner, S Clausi, S Gilman, S. Clausi, S. Romano, T Takahashi, Y Kawai, Z Yang   +63 more
core   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Congenital muscular dystrophy: from muscle to brain. [PDF]

, 2016
Congenital muscular dystrophies (CMDs) are a wide group of muscular disorders that manifest with very early onset of muscular weakness, sometime associated to severe brain involvement.The histologic pattern of muscle anomalies is typical of dystrophic ...
Corsello G, Falsaperla R, Parano E, Pavone P, Praticò AD, Rizzo R, Ruggieri M, Vitaliti G   +7 more
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

The neural underpinnings of cognitive and postural profile of a young adult with congenital cerebellar athrophy: a longitudinal case report

Frontiers in Neuroscience
For decades the cerebellum has been conceived as an organ chiefly involved in motor control, gait and posture. However, more recent and increasing evidence shows that the cerebellum is also involved in cognition and affection, and that damage to this ...
Maria Devita, Maria Devita, Adele Ravelli, Chiara Ceolin, Chiara Ceolin, Marina De Rui, Lorenzo Pini, Lorenzo Pini, Matteo Bendini, Michela Sarlo, Giuseppe Sergi, Umberto Castiello, Daniela Mapelli, Chiara Begliomini, Chiara Begliomini   +14 more
doaj   +1 more source

Ataxia with oculomotor apraxia type 2: clinical, biological and genotype/phenotype correlation study of a cohort of 90 patients [PDF]

, 2009
Ataxia with oculomotor apraxia type 2 (AOA2) is an autosomal recessive disease due to mutations in the senataxin gene, causing progressive cerebellar ataxia with peripheral neuropathy, cerebellar atrophy, occasional oculomotor apraxia and elevated alpha ...
Ali-Pacha, L, Anheim, M, Arning, L, Barbot, C, Benhassine, T, Brice, A, Chabrol, B, Charles, P, Chbicheb, M, Coutinho, P, De Bleecker, Jan, Delaunoy, JP, Drouot, N, Durr, A, Fleury, M, Fritsch, M, Gazulla, J, Goizet, C, Hamri, A, Koenig, M, Koht, J, Le Ber, I, M'Zahem, A, Marelli, C, Monga, B, Mukhtar, M, Murphy, R, Pouget, J, Salih, M, Schols, L, Sequeiros, J, Synofzik, M, Tazir, M, Tranchant, C, Watanabe, M   +34 more
core   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source