Results 71 to 80 of about 77,401 (305)

Disease modifying therapy for multiple system atrophy – Parkinsonian Type [PDF]

, 2017
BACKGROUND: Multiple System Atrophy –Parkinsonian Type (MSA-P) is a rare, rapidly progressive neurodegenerative disease without any current treatment.
Dwyer, Sean Sullivan
core  

International Veterinary Epilepsy Task Force recommendations for systematic sampling and processing of brains from epileptic dogs and cats [PDF]

, 2015
Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities.
A Jeans, A Katelaris, A Klang, A Pakozdy, A Pakozdy, A Pitkanen, A Woznicka, Akos Pakozdy, AM Wahle, Andrea Fischer, Andrea Tipold, Clare Rusbridge, DM Kowalska, Edward E. Patterson, ES Park, Eva Wagner, F Reinoso-Suárez, Francisco Fernández-Flores, G Isoardo, H Potschka, H Urbach, Heidrun Potschka, HO Lüders, Holger A. Volk, I Blumcke, I Toyoda, IK Hwang, J O’Muircheartaigh, Jacques Penderis, JE Cavazos, JH Margerison, JN Kornegay, JY Cheong, K Baiker, K Kobow, Karen Muñana, Kaspar Matiasek, L Wang, LP Hudson, Luisa De Risio, M Fischer, M Manford, M Oehmichen, M Sasaki, M Singer, M Thom, M Thom, M Wolf, Marco Rosati, Martí Pumarola i Batlle, ME Milne, Mette Berendt, Michael Podell, MP Witter, N Shihab, PS Buckmaster, R Adamec, R Crooks, RE Adamec, RE Adamec, RM Packer, RN Auer, Robyn G. Farquhar, S Lomoio, S Schriefl, Sam Long, Simon Platt, Sofie F. M. Bhatti, SY Bando, T Kuwabara, TS Jokinen, U Seneviratne, VA Gil, Veronika M. Stein, Y Masuo, Z Ahmed   +75 more
core   +7 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases [PDF]

, 2008
Background: Paraneoplastic neurological syndromes (PNS) are indirect remote effects of cancer on the nervous system, often associated with the presence of specific serum antibodies.
Hoffmann, L. A., Jarius, S., Johannis, W., Koenig, F., Krumbholz, Markus, La Fougere, Christian, Newman, T., Pellkofer, Hannah Luise, Schueller, M., Vincent, A., Voltz, Raymond   +10 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Postmortem Cerebellar Volume Is Not Reduced in Essential Tremor: A Comparison with Multiple System Atrophy and Controls

Journal of Parkinson’s Disease, 2023
Background: Essential tremor (ET) is a common movement disorder in which cerebellar microscopic and volume alterations have been repeatedly reported although with disagreement between studies.
Cécilia Tremblay, Geidy E. Serrano, Nathaniel Dunckley, Nan Zhang, Kimberly L. Fiock, Charles H. Adler, Erika Driver-Dunckley, Shyamal H. Mehta, Holly A. Shill, Thomas G. Beach   +9 more
doaj   +1 more source

Concomitant granule cell neuronopathy in patients with natalizumab-associated PML [PDF]

, 2016
Granule cell neuronopathy (GCN) is a rare JC virus infection of the cerebellar granule cell neurons in immunocompromised patients. On brain imaging, GCN is characterized by cerebellar atrophy which can be accompanied by infratentorial white matter ...
Eijk, J.J.J. (Jeroen) van, Killestein, J. (Joep), Siepman, D.A.M. (Dorine), Wattjes, M.P. (Mike P.), Wijburg, M.T. (Martijn T.)   +4 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

A case report of persistent cerebellar dysfunction following acute lithium toxicity

BMC Neurology
Background Acute lithium toxicity can cause cerebellar impairment, but long-term follow-up data are limited. We describe a case of acute lithium intoxication followed by progressive cerebellar atrophy and permanent cerebellar dysfunction.
Jiabei Nie, Qing Gao, Yiming Li, Xiaomeng Xu, Yuyan Tan   +4 more
doaj   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source