Results 111 to 120 of about 5,502 (160)

The benchmarking and application of tag-degraders in vivo to validate therapeutic targets. [PDF]

Nat Commun
Magtoto CM, Mieruszynski S, Dong H, Ng AP, Di Rago L, Kueh AJ, Brzozowski M, Grohmann C, Walker JR, Chua NK, Dagley LF, Ciulli A, Lessene G, Herold MJ, Heath JK, Silke J, Feltham R.   +16 more
europepmc   +1 more source

The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design. [PDF]

ChemMedChem
Nikovia K, Kapsalis M, Georgoulakis M, Panousis A, Neochoritis CG.   +4 more
europepmc   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma. [PDF]

FEBS J
Fuentes-Lacouture MC, Nandana D, Ramasamy K, Thakurta A.   +3 more
europepmc   +1 more source

Targeted degradation of CBP/p300 by CBPD-409 exhibits robust anti-myeloma activity. [PDF]

Leukemia
Corradini S, Maksimos M, Azab F, Arsalani S, Nwarunma E, Watt G, Soutar R, Powell M, Henderson R, Travers J, Chen Z, Wang S, Azab AK, Williams MTS.   +13 more
europepmc   +1 more source

Viability of <i>Dugesia dorotocephala</i> Planaria with the Senolytic Drug ARV-825. [PDF]

MicroPubl Biol
Wells A, Munroe WH.
europepmc   +1 more source

Drug Resistance in Multiple Myeloma: Tumor-Intrinsic Mechanisms and the Bone Marrow Microenvironment. [PDF]

Cell Biochem Funct
Chen Y, Huang W, Tang M, Wang X.
europepmc   +1 more source

Discovery of SD-965 as a Potent, Selective, and Efficacious STAT3 PROTAC Degrader. [PDF]

J Med Chem
Wu D, Zhou H, Bai L, Acharyya RK, Metwally H, McEachern D, Wang M, Tošović J, Rej RK, Wang M, Wen B, Sun D, Wang S.   +12 more
europepmc   +1 more source

Binding Modes of Thalidomide Derivatives in Cereblon-Neosubstrate Complexes Revealed by Molecular Dynamics and Free Energy Calculations. [PDF]

ACS Omega
Martín V, Andjelkovic M, Barrientos C, Leon I, Tuñón I.   +4 more
europepmc   +1 more source

Cereblon upregulation overcomes thalidomide resistance in multiple myeloma through mitochondrial functional reprogramming. [PDF]

BMB Rep
Marquez J, Park N, Choi JH, Garcia MVF, Flores J, Nyamaa B, Seol JE, Kim HK, Shin MG, Park SG, Han J.   +10 more
europepmc   +1 more source

Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression. [PDF]

Cell Chem Biol
Liao C, Lyu S, Johnson RL, Shang T, Wang X, Gildor N, Li S, Williams NS, James LI, Hu L, Zhang Q.   +10 more
europepmc   +1 more source