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Computational Biology and Chemistry, 2022 Background: Cereblon, an extensively studied multifunctional protein, is a Cullin 4-RING E3 ubiquitin ligase complex component. Cereblon is a well-known target of thalidomide and its derivatives.
Abdul Ajees Abdul Salam +1 more
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International Journal of Molecular Sciences, 2017 Immunomodulatory drugs (IMiDs) are profoundly active compounds in the treatment of patients with multiple myeloma (MM). However, despite the fact that treatment with IMiDs has dramatically improved survival for patients with MM, the majority of MM ...
Ye Xu, A Keith Stewart
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FASEB Journal, 2020 Cereblon (CRBN) is a substrate recruiter element of the E3 cullin 4-RING ubiquitin ligase complex, and a binding target of immunomodulatory agents (IMiDs).
Neil Vargesson, Christopher B Mahony
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Ligands for cereblon: 2017–2021 patent overview
Expert Opinion on Therapeutic Patents, 2022Mikhail Krasavin, Alexander Kazantsev
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Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs
Angewandte Chemie - International Edition, 2021Taosheng Chen +2 more
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Cereblon contributes to cardiac dysfunction by degrading Cav1.2α
European Heart Journal, 2022Jong Yeon Hwang, Min Kim, Hyoung Kyu Kim
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