Results 61 to 70 of about 4,302 (134)

The Drug Vehicle and Solvent N-Methylpyrrolidone Is an Immunomodulator and Antimyeloma Compound

Cell Reports, 2014
N-methyl-2-pyrrolidone (NMP) is a common solvent and drug vehicle. We discovered unexpected antineoplastic and immunomodulatory activity of NMP in a cMYC-driven myeloma model.
Jake Shortt, Andy K. Hsu, Benjamin P. Martin, Karen Doggett, Geoffrey M. Matthews, Maria A. Doyle, Jason Ellul, Tina E. Jockel, Daniel M. Andrews, Simon J. Hogg, Andrea Reitsma, David Faulkner, P. Leif Bergsagel, Marta Chesi, Joan K. Heath, William A. Denny, Philip E. Thompson, Paul J. Neeson, David S. Ritchie, Grant A. McArthur, Ricky W. Johnstone   +20 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, Volume 20, Issue 10, Page 2466-2489, October 2026.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications

MedComm – Oncology
Molecular glue degraders (MGDs) represent an emerging therapy that exploits ubiquitin–proteasome pathways to eliminate otherwise intractable proteins. By stabilizing E3 ligases–target protein interactions, they enable event‐driven degradation, advancing ...
Jinfeng Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang   +3 more
doaj   +1 more source

A novel nano-immunoassay method for quantification of proteins from CD138-purified myeloma cells: biological and clinical utility

Haematologica, 2018
Protein analysis in bone marrow samples from patients with multiple myeloma has been limited by the low concentration of proteins obtained after CD138+ cell selection.
Irena Misiewicz-Krzeminska, Luis Antonio Corchete, Elizabeta A. Rojas, Joaquín Martínez-López, Ramón García-Sanz, Albert Oriol, Joan Bladé, Juan-José Lahuerta, Jesús San Miguel, María-Victoria Mateos, Norma C. Gutiérrez   +10 more
doaj   +1 more source

Proteolysis targeting chimeric molecules as therapy for multiple myeloma: efficacy, biomarker and drug combinations

Haematologica, 2019
Proteolysis targeting chimeric molecule ARV 825 causes ubiquitination of bromodomains resulting in their efficient degradation by proteasome activity. Bromodomain degradation down-regulates MYC transcription contributing to growth inhibition of various ...
Su Lin Lim, Alisa Damnernsawad, Pavithra Shyamsunder, Wee Joo Chng, Bing Chen Han, Liang Xu, Jian Pan, Dakle Pushkar Pravin, Serhan Alkan, Jeffrey W. Tyner, H. Phillip Koeffler   +10 more
doaj   +1 more source

The Relationship Between the Expression of CRBN in Peripheral Blood and the Severity and Prognosis of Adult Sepsis

International Journal of General Medicine, 2023
Zhiming Kuang,1 Qiuping Gu1,2 1Department of Critical Care Medicine, Ganzhou People’s Hospital, Ganzhou, Jiangxi Province, 341000, People’s Republic of China; 2Department of Gastroenterology, Ganzhou People’s Hospital, Ganzhou, Jiangxi Province, 341000 ...
Kuang Z, Gu Q
doaj  

Investigation of the anti-cancer drugs imatinib and thalidomide using analytical spectroscopy (FT-IR, UV-Vis) and molecular docking simulations

Results in Chemistry
Cancer is one of the most fatal diseases in modern civilisation, accounting for a significant number of deaths each year. The continued investigation of the medical effects of cancer is still an important and fascinating field of study.
P. Venkata Ramana, Y. Rama Krishna, Prasadarao Bobbili, K. Venkata Prasad, K. Chandra Mouli   +4 more
doaj   +1 more source

Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3

Molecular Therapy: Nucleic Acids
Decoy oligodeoxynucleotides (ODNs) allow targeting undruggable transcription factors, such as STAT3, but their limited potency and lack of delivery methods hampered translation.
Jeremy Hall, Zhuoran Zhang, Supriyo Bhattacharya, Dongfang Wang, Marice Alcantara, Yong Liang, Piotr Swiderski, Stephen Forman, Larry Kwak, Nagarajan Vaidehi, Marcin Kortylewski   +10 more
doaj   +1 more source

Design, Synthesis, Biological Studies and Putative Binding Mode of Novel Benzotriazolothalidomide Derivatives as Cereblon Ligands. [PDF]

Chem Biol Drug Des
Ganguly P, Kundu M, Sarkar T, Dcosta G, Banerjee K, Banerjee R, Hajra AK, Sahabuddin S, Basu S, Das A, Das S, Barik R, Ali MA.   +12 more
europepmc   +1 more source

In Silico Analysis of Enantioselective Binding of Pomalidomide Targets for Multiple Myeloma. [PDF]

Chirality
Vardhan G, Kumar V, Kumar A, Handu S, Dhamija P.   +4 more
europepmc   +1 more source