Results 81 to 90 of about 5,502 (160)

A novel nano-immunoassay method for quantification of proteins from CD138-purified myeloma cells: biological and clinical utility

Haematologica, 2018
Protein analysis in bone marrow samples from patients with multiple myeloma has been limited by the low concentration of proteins obtained after CD138+ cell selection.
Irena Misiewicz-Krzeminska, Luis Antonio Corchete, Elizabeta A. Rojas, Joaquín Martínez-López, Ramón García-Sanz, Albert Oriol, Joan Bladé, Juan-José Lahuerta, Jesús San Miguel, María-Victoria Mateos, Norma C. Gutiérrez   +10 more
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Supplementary Data from Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL

, 2022
Supplementary Data from Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in ...
Anita K. Gandhi (14891744), Vivek S. Chopra (15045122), Maria Ortiz Estevez (15045125), Hsiling Chiu (15045119), Patrick R. Hagner (15045116), Fadi Towfic (394366), Martino Colombo (3298965), Nisha Patel (336148), Michelle F. Waldman (15045128), Remco Loos (5791577)   +9 more
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Proteolysis targeting chimeric molecules as therapy for multiple myeloma: efficacy, biomarker and drug combinations

Haematologica, 2019
Proteolysis targeting chimeric molecule ARV 825 causes ubiquitination of bromodomains resulting in their efficient degradation by proteasome activity. Bromodomain degradation down-regulates MYC transcription contributing to growth inhibition of various ...
Su Lin Lim, Alisa Damnernsawad, Pavithra Shyamsunder, Wee Joo Chng, Bing Chen Han, Liang Xu, Jian Pan, Dakle Pushkar Pravin, Serhan Alkan, Jeffrey W. Tyner, H. Phillip Koeffler   +10 more
doaj   +1 more source

Biophysical and structural studies of the ligand-induced interaction of multiple SALL4 zinc finger domains with cereblon

, 2023
Although several proteins are known to interact with cereblon in the presence of molecular glues (MGs), the molecular basis of selectivity is emerging. An understanding of these interactions is important when designing drugs that selectively degrade a ...
Wartchow, Charles
core  

Cereblon pathway biomarkers and immune profiles in patients with myeloma receiving post-ASCT lenalidomide maintenance (LEOPARD)

, 2021
Cereblon pathway biomarkers and immune profiles in patients with myeloma receiving post-ASCT lenalidomide maintenance ...
W Pierceall (13404597), S Parekh (9877493), A Thakurta (13404600), M Ramachandran (9141881), A Schwarer (13404333), AW Roberts (15780704), N Kennedy (11650153), P Campbell (4048558), P Walker (13404330), J Reynolds (9209240), T Khong (13404411), Y Ren (7930649), A Spencer (8907200), M Wang (557059), R Filshie (13404594), S Norton (12496225), A Kalff (13404408), M Young (9995819), M Guo (9874145), U Oppermann (7812758)   +19 more
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Abstract SY37-02: Ligand-directed degradation of GSPT1 by a novel cereblon modulator drives potent antitumor effects

, 2017
The protein cereblon is part of the CRL4-CRBN E3 ubiquitin ligase complex, and has been shown to be the molecular target for the drugs lenalidomide and pomalidomide.
Barbra Pagarigan, Tam Tran, Takumi Ito, Chin-Chu Lu, Hiroshi Handa, Mariko Riley, Antonia Lopez-Girona, Brian E. Cathers, Mary Matyskiela, Gilles Carmel, Shuichan Xu, Philip Chamberlain, Gang Lu, Karen Miller, Derek Nguyen, Lyn'Al Nosaka, Svetlana Gaidarova, Gabriel Lander, Jack Houston, Alexander Ruchelman, Wei Fang, Nai-Yu Wang, James Carmichale, Thomas O. Daniel   +23 more
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Estudio computacional de los cambios estructurales de dos mutaciones de la proteína Cereblon

, 2020
Cereblon protein (CRBN) is the receptor for substrates that bind to the CRL4CRBN E3 ubiquitin ligase complex, whose function is to control the selective degradation of proteins during various cellular processes...La proteína Cereblon (CRBN) es el ...
Ayala Ruano, Andrés Sebastián
core  

Multiples Myelom: Cereblon als Regulator der Wirksamkeit von Imiden?

, 2012
Mehrere Studien beschäftigten sich auf dem ASH-Kongress mit der Rolle die das Proteins Cereblon (CRBN) bei Patienten mit multiplem Myelom (MM) spielt. Neue Erkenntnisse zeigen laut Dr.
Alexander Kretzschmar
core   +1 more source

Design, synthesis, and evaluation of benzenecarboxamide-based cereblon ligands

, 2023
Rak je skupina sorodnih bolezni, katerim je skupna nenadzorovana delitev celic. Nastane zaradi nepopravljive spremembe v celičnem jedru kot posledica mutacije genov v spolnih ali telesnih celicah.
Bele, Teja
core  

The Relationship Between the Expression of CRBN in Peripheral Blood and the Severity and Prognosis of Adult Sepsis

International Journal of General Medicine, 2023
Zhiming Kuang,1 Qiuping Gu1,2 1Department of Critical Care Medicine, Ganzhou People’s Hospital, Ganzhou, Jiangxi Province, 341000, People’s Republic of China; 2Department of Gastroenterology, Ganzhou People’s Hospital, Ganzhou, Jiangxi Province, 341000 ...
Kuang Z, Gu Q
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