Results 91 to 100 of about 32,043 (291)

A Mathematical model for Alzheimer's disease: An approach via stochastic homogenization of the Smoluchowski equation [PDF]

arXiv, 2019
In this note, we apply the theory of stochastic homogenization to find the asymptotic behavior of the solution of a set of Smoluchowski's coagulation-diffusion equations with non-homogeneous Neumann boundary conditions. This system is meant to model the aggregation and diffusion of $\beta$-amyloid peptide (A$\beta$) in the cerebral tissue, a process ...
arxiv  

Animal models of cerebral amyloid angiopathy

Clinical Science, 2017
Cerebral amyloid angiopathy (CAA), due to vascular amyloid β (Aβ) deposition, is a risk factor for intracerebral haemorrhage and dementia. CAA can occur in sporadic or rare hereditary forms, and is almost invariably associated with Alzheimer’s disease (AD).
Jakel, L., Van Nostrand, W.E., Nicoll, J.A.R., Werring, D.J., Verbeek, M.M., Verbeek, M.M.   +5 more
openaire   +8 more sources

Minocycline in Severe Cerebral Amyloid Angiopathy: A Single‐Center Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Evidence from animal studies suggests that minocycline may reduce lobar intracerebral hemorrhage (ICH) recurrence in cerebral amyloid angiopathy, possibly by inhibiting perivascular extracellular matrix degradation in cerebral small vessels ...
Francesco Bax, Andrew Warren, Avia Abramovitz Fouks, Hilde van den Brink, Susanne J. van Veluw, Mariel G. Kozberg, Steven M. Greenberg   +6 more
doaj   +1 more source

Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura

Annals of Neurology, 2019
Amyloid‐β transmission has been described in patients both with and without iatrogenic Creutzfeldt–Jakob disease; however, there is little information regarding the clinical impact of this acquired amyloid‐β pathology during life.
G. Banerjee, M. Adams, Z. Jaunmuktane, G. Alistair Lammie, B. Turner, M. Wani, I. Sawhney, H. Houlden, S. Mead, S. Brandner, D. Werring   +10 more
semanticscholar   +1 more source

Complement dysregulation in human tauopathies

Brain Pathology, EarlyView.
Complement protein and activation product levels were assessed in post‐mortem frontal cortex from three distinct subtypes of Tauopathy: Corticobasal degeneration, globular glial tauopathy, and Pick's disease. Quantification of complement proteins by immunohistochemistry and ELISA showed elevation of key complement proteins (C1q) regulators (FI) and ...
Jacqui Nimmo, Samuel Keat, Louis De Muynck, B. Paul Morgan   +3 more
wiley   +1 more source

Cerebral amyloid angiopathy impact on endothelium [PDF]

Experimental Gerontology, 2012
Cerebral amyloid angiopathy (CAA) is an age-associated disease characterized by amyloid deposition in cerebral and meningeal vessel walls. CAA is detected in the majority of the individuals with dementia and also in a large number of non-demented elderly individuals.
Grinberg, Lea Tenenholz, Korczyn, Amos D, Heinsen, Helmut   +2 more
openaire   +5 more sources

Cortical superficial siderosis and bleeding risk in cerebral amyloid angiopathy

Neurology, 2019
Objective To assess the association of cortical superficial siderosis (cSS) presence and extent with future bleeding risk in cerebral amyloid angiopathy (CAA).
A. Charidimou, G. Boulouis, S. Greenberg, A. Viswanathan   +3 more
semanticscholar   +1 more source

Circulating amyloid beta 1‐40 peptide as an associate of renal function decline

European Journal of Clinical Investigation, Volume 55, Issue 5, May 2025.
In this cohort study, we explored the association between amyloid‐beta 1‐40 (Aβ1‐40) plasma levels and kidney function and its clinical implications in 811 consecutive individuals with variable cardiovascular risk. Increased Aβ1‐40 was bidirectionally and consistently associated with worse kidney function at two different time points.
Georgios Mavraganis, Georgios Georgiopoulos, Georgios Zervas, Evmorfia Aivalioti, Dimitrios Delialis, Ioannis Petropoulos, Nikolaos Rachiotis, Christina Konstantaki, Chrysoula Moustou, Maria‐Aggeliki Dimopoulou, Marco Sachse, Simon Tual‐Chalot, Kateryna Sopova, Erasmia Psimmenou, Konstantinos Stellos, Kimon Stamatelopoulos   +15 more
wiley   +1 more source

Research progress of cerebral amyloid angiopathy associated with inflammation

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Cerebral amyloid angiopathy associated with inflammation (CAA⁃I) is a rare subtype of cerebral amyloid angiopathy (CAA), and is increasingly recognized by neurologists. CAA⁃Iischaracterized by the pathological hallmarks of both CAA and vasculitis.
Wen⁃hao ZHANG, Ran LIU, Yi⁃ning HUANG   +2 more
doaj  

Progression of cerebral amyloid angiopathy: a pathophysiological framework

Lancet Neurology, 2023
E. Koemans, J. Chhatwal, S. J. Veluw, E. Etten, M. Osch, M. V. Walderveen, H. Sohrabi, Mariel G Kozberg, Z. Shirzadi, G. Terwindt, M. Buchem, E. Smith, D. Werring, R. Martins, M. Wermer, S. Greenberg   +15 more
semanticscholar   +1 more source