Results 101 to 110 of about 28,628 (268)

Cerebral Small Vessel Disease: Targeting Oxidative Stress as a Novel Therapeutic Strategy? [PDF]

, 2016
Cerebral small vessel disease (SVD) is a major contributor to stroke, and a leading cause of cognitive impairment and dementia. Despite the devastating effects of cerebral SVD, the pathogenesis of cerebral SVD is still not completely understood. Moreover,
Alyson A. Miller, T. Michael De Silva
core   +2 more sources

APOE isoform‐associated tau oligomer polymorphs differ in synaptotoxicity and seeding activity

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Pathological tau aggregates form distinct polymorphic species across diseases and even across Alzheimer's disease (AD) patients. However, tau aggregate polymorphism across the apolipoprotein E isoforms (APOE ε2, ε3, ε4), the strongest predictors of late‐onset AD development, is unknown.
Naomi Moreno, Nikita Shchankin, Leiana Fung, Nicha Puangmalai, Nemil Bhatt, Md Anzarul Haque, Yingxin Zhao, C. Dirk Keene, Agenor Limon, Rakez Kayed   +9 more
wiley   +1 more source

White matter hyperintensity modulates the amyloid‐tau‐cognition association and anti‐amyloid treatment efficacy in asymptomatic older adults

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION White matter hyperintensities (WMH), a key imaging biomarker of small vessel injury, may play a complex role in Alzheimer's disease (AD). We hypothesize that WMH not only directly contributes to cognitive decline but also moderates the relationship among AD pathology, treatment, and cognitive decline.
Zixuan Lin, Yiwen Hong, Yizhe Hu, Qian Xiao, Shin‐Lei Peng, Dan Wu, Tengfei Guo, Dengrong Jiang   +7 more
wiley   +1 more source

Cerebral Amyloid Angiopathy-Related Inflammation: A Case Report and Literature Review

, 2023
Chanjin Park, Eun Sun Choi, Eunhee Kim
openalex   +1 more source

Apolipoprotein E ε4 homozygosity exacerbates retinal and cerebral microvascular dysfunction in Alzheimer's disease: A mediation analysis of vascular contributions to cognitive decline

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for Alzheimer's disease (AD), with homozygous carriers (ε4/ε4) experiencing accelerated cognitive decline. While its role in amyloid and tau pathology is established, its impact on retinal and cerebral microvasculature remains underexplored. METHODS A total of 107 AD (
Yuntao Liu, Hanyu Zhu, Youjie Wang, Xiaoqian Luan, Jiahui Chen, Jiajing Qian, Jianing Shen, Yinhe Liu, Caiyun Wen, Lin Cao, Bo Tang, Ho Ko, William Robert Kwapong, Zhen Wang   +13 more
wiley   +1 more source

Comorbidity of cerebral amyloid angiopathy and Alzheimer's disease. Clinical case analysis

, 2023
A. Yu. Emelin, V. Yu. Lobzin, A. Yu. Efimtsev, S. V. Vorobyov   +3 more
openalex   +1 more source

Therapeutic and Diagnostic Roles of MSC‐Derived Exosomes in Alzheimer's Disease

Brain and Behavior, Volume 15, Issue 12, December 2025.
Mesenchymal stem cell (MSC)‐derived exosomes deliver bioactive cargos, including miRNAs, neurotrophic factors, and antioxidant molecules, that modulate neuronal survival, microglial phenotype, and amyloid plaque clearance in Alzheimer's disease. These actions reduce apoptosis, oxidative stress, and inflammation, promote neurogenesis, enhance Aβ ...
Vinay Shankar Patil, Bhavin Parekh, Amit Sharma, Husni Farah, Renuka Jyothi‐S, Swati Mishra, Anima Nanda, Shaker Al‐Hasnaawei, Manoj Kumar‐Mishra   +8 more
wiley   +1 more source

A Collet–Sicard syndrome due to internal carotid artery dissection associated with cerebral amyloid angiopathy–related inflammation

SAGE Open Medical Case Reports, 2018
Background: Cerebral amyloid angiopathy–related inflammation is a rare condition with approximately 100 reported cases. Its clinical manifestations are varied. We report here a novel presentation of this disease.
Vanessa Saliou, Douraied Ben Salem, Julien Ognard, Dewi Guellec, Pascale Marcorelles, François Rouhart, Fabien Zagnoli, Serge Timsit   +7 more
doaj   +1 more source

Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease [PDF]

, 2008
BACKGROUND AND PURPOSE: Superficial siderosis of the central nervous system results from chronic bleeding in the superficial layers of the cortex and spinal cord.
Feldman, H., Forster, B., Mackenzie, I., Maia, L., Martzke, J., Woolfenden, A.   +5 more
core  

Cerebral amyloid angiopathy: an update

Journal of Neurology, 2023
Schroeder, B. E., Robertson, N. P., Hughes, T. A. T.   +2 more
openaire   +2 more sources