Results 101 to 110 of about 32,043 (291)
Microbial amyloids in neurodegenerative amyloid diseases
The FEBS Journal, Volume 292, Issue 6, Page 1265-1281, March 2025.Numerous microbes, including those indigenous to the human microbiome, produce amyloidogenic proteins. These proteins have critical functions in bacterial physiology and their lifestyles. Emerging evidence indicates that microbial amyloids also interact directly or indirectly with host‐derived amyloid proteins, such as those which underlie Parkinson's ...
Timothy Sampson
wiley +1 more source
LRP1 and Cerebral Amyloid Angiopathy
Future Neurology, 2008 Cerebral amyloid angiopathy (CAA), which causes intracerebral hemorrhage in the elderly population, is a major hallmark of Alzheimer’s disease. In CAA, amyloid-β (Aβ) deposition is mainly detected in the cortex and leptomeningeal arteries along the interstitial fluid drainage pathway.
Kanekiyo, Takahisa, Bu, Guojun
openaire +3 more sources
PDB_Amyloid: The Extended Live Amyloid Structure List from the PDB [PDF]
arXiv, 2018 The Protein Data Bank (PDB) contains more than 135 000 entries today. From these, relatively few amyloid structures can be identified, since amyloids are insoluble in water. Therefore, mostly solid state NMR-recorded amyloid structures are deposited in the PDB.
arxiv
Unprecedented Combination of Rare Degenerative Pathologies in an Octogenarian Ex‐Football Player
Neuropathology, EarlyView.ABSTRACT A 79‐year‐old former professional football player presented with language deficits and cognitive changes. A year later, he had difficulty completing sentences, and 3 years after onset, was reduced to one‐word answers. He developed severe apathy and agitation, and became more impulsive.
Shelley L. Forrest +6 more
wiley +1 more source
Effect of Surfaces on Amyloid Fibril Formation [PDF]
arXiv, 2017 Using atomic force microscopy (AFM) we investigated the interaction of amyloid beta (Ab) (1 42) peptide with chemically modified surfaces in order to better understand the mechanism of amyloid toxicity, which involves interaction of amyloid with cell membrane surfaces.
arxiv
Immunotherapy with ponezumab for probable cerebral amyloid angiopathy
Annals of Clinical and Translational Neurology, 2019 Cerebral amyloid angiopathy (CAA) is caused by cerebrovascular deposition of β‐amyloid fragments leading to cerebrovascular dysfunction and other brain injuries.
C. Leurent +22 more
semanticscholar +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker +2 more
wiley +1 more source
Annals of Neurology, Volume 97, Issue 6, Page 1110-1121, June 2025.Objective Despite diagnostic criteria refinements, Parkinson's disease (PD) clinical diagnosis still suffers from a not satisfying accuracy, with the post‐mortem examination as the gold standard for diagnosis. Seminal clinicopathological series highlighted that a relevant number of patients alive‐diagnosed with idiopathic PD have an alternative post ...
Lazzaro di Biase +2 more
wiley +1 more source
The Budapest Amyloid Predictor and its Applications [PDF]
arXiv, 2020 The amyloid state of proteins is widely studied with relevancy in neurology, biochemistry, and biotechnology. In contrast with amorphous aggregation, the amyloid state has a well-defined structure, consisting of parallel and anti-parallel $\beta$-sheets in a periodically repeated formation.
arxiv