Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage [PDF]
, 2004 BACKGROUND: Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates.
Freeman, Melissa J +6 more
core +3 more sources
Cerebral Hypoperfusion and the Energy Deficit in Alzheimer's Disease [PDF]
, 2016 There is a perfusion deficit in Alzheimer's disease (AD), commencing in the precuneus and spreading to other parts of the cerebral cortex. The deficit anticipates the development of dementia, contributes to brain damage, and is caused by both functional ...
Love, Seth, Miners, J. Scott
core +4 more sources
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism [PDF]
, 2018 Table S1. Demographic and clinical features of human subjects used in this study. Figure S1. Aβ deposition in microvessels in AD patients and APPSw/0 mice. Figure S2. Biochemical analysis of Aβ42 aggregates. Figure S3.
Herz, Joachim +9 more
core +3 more sources
Cells, 2021 Alzheimer’s disease (AD) is the most prevalent cause of dementia and is pathologically characterized by the presence of parenchymal senile plaques composed of amyloid β (Aβ) and intraneuronal neurofibrillary tangles of hyperphosphorylated tau protein ...
Rebecca M Parodi-Rullán +2 more
semanticscholar +1 more source
Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly. [PDF]
, 2015 In cognitively normal (CN) elderly individuals, white matter hyperintensities (WMH) are commonly viewed as a marker of cerebral small vessel disease (SVD).
Alzheimer’s Disease Neuroimaging Initiative +7 more
core +2 more sources
Cerebral amyloid angiopathy mimicking central nervous system metastases: a case report
Journal of Medical Case Reports, 2018 Background This case describes an unusual presentation of an intracranial hemorrhage first thought to be metastatic disease on computed tomography and magnetic resonance imaging. The healthcare team completed an exhaustive search for a primary malignancy
Christopher DeZorzi +3 more
doaj +1 more source
Gait in Cerebral Amyloid Angiopathy
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Gait is a complex task requiring coordinated efforts of multiple brain networks. To date, there is little evidence on whether gait is altered in cerebral amyloid angiopathy (CAA).
Breni Sharma +10 more
doaj +1 more source
Peak Width of Skeletonized Mean Diffusivity as Neuroimaging Biomarker in Cerebral Amyloid Angiopathy
American Journal of Neuroradiology, 2021 BACKGROUND AND PURPOSE: Whole-brain network connectivity has been shown to be a useful biomarker of cerebral amyloid angiopathy and related cognitive impairment.
N. Raposo +14 more
semanticscholar +1 more source
Early MRI imaging and follow-up study in cerebral amyloid angiopathy
Open Medicine, 2021 To study the imaging features of leukoaraiosis (LA) and hemorrhage in cerebral amyloid angiopathy (CAA) patients.
Zhang Shan-chun +8 more
doaj +1 more source
Taxifolin: A Potential Therapeutic Agent for Cerebral Amyloid Angiopathy
Frontiers in Pharmacology, 2021 Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of β-amyloid (Aβ) in the walls of cerebral vessels, leading to complications such as intracerebral hemorrhage, convexity subarachnoid hemorrhage and cerebral microinfarcts.
S. Saito +4 more
semanticscholar +1 more source