Results 41 to 50 of about 32,043 (291)

Neuropathological correlates of cortical superficial siderosis in cerebral amyloid angiopathy

Brain : a journal of neurology, 2020
Cortical superficial siderosis (cSS) is an established hemorrhagic neuroimaging marker of cerebral amyloid angiopathy (CAA) and emerging as a strong independent risk factor for future lobar intracerebral hemorrhage.
Susanne J. van Veluw, A. Charidimou, M. Frosch, S. Greenberg   +3 more
semanticscholar   +1 more source

Recurrent Subarachnoid Bleeding and Superficial Siderosis in a Patient with Histopathologically Proven Cerebral Amyloid Angiopathy

Case Reports in Neurology, 2011
A 68-year-old man with a history of hypertension presented with recurrent subarachnoid bleeding. Brain MRI showed superficial siderosis, and diagnostic cerebral angiograms did not show any intracranial vascular malformation or arterial aneurism.
P. Profice, F. Pilato, G. Della Marca, C. Colosimo, S. Gaudino, V. Arena, A. Pavone, V. Di Lazzaro   +7 more
doaj   +1 more source

Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy

Journal of Alzheimer's Disease, 2020
Background: There is limited data on cerebrospinal fluid (CSF) biomarkers in sporadic amyloid-β (Aβ) cerebral amyloid angiopathy (CAA). Objective: To determine the profile of biomarkers relevant to neurodegenerative disease in the CSF of patients with ...
G. Banerjee, G. Ambler, A. Keshavan, R. Paterson, M. Foiani, J. Toombs, A. Heslegrave, J. Dickson, F. Fraioli, A. Groves, M. Lunn, Nick C Fox, H. Zetterberg, J. Schott, D. Werring   +14 more
semanticscholar   +1 more source

Bicine promotes rapid formation of β-sheet-rich amyloid-β fibrils.

PLoS ONE, 2020
Fibrillar aggregates of amyloid-β (Aβ) are the main component of plaques lining the cerebrovasculature in cerebral amyloid angiopathy. As the predominant Aβ isoform in vascular deposits, Aβ40 is a valuable target in cerebral amyloid angiopathy research ...
Hye Yun Kim, HeeYang Lee, Jong Kook Lee, Hyunjin Vincent Kim, Key-Sun Kim, YoungSoo Kim   +5 more
doaj   +1 more source

Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer’s disease mouse model

Acta Neuropathologica Communications, 2020
Cerebral amyloid angiopathy (CAA), defined as the accumulation of amyloid-beta (Aβ) on the vascular wall, is a major pathology of Alzheimer’s disease (AD) and has been thought to be caused by the failure of Aβ clearance.
Shinheun Kim, J. Ahn, Hyunwoo Yang, Peter Lee, G. Koh, Y. Jeong   +5 more
semanticscholar   +1 more source

Cerebrovascular morphology in aging and disease -- imaging biomarkers for ischemic stroke and Alzheimers disease [PDF]

arXiv, 2022
Background and Purpose: Altered brain vasculature is a key phenomenon in several neurologic disorders. This paper presents a quantitative assessment of vascular morphology in healthy and diseased adults including changes during aging and the anatomical variations in the Circle of Willis (CoW).
arxiv  

Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer’s disease

Alzheimer's & Dementia, 2020
Cerebrovascular pathologies including cerebral amyloid angiopathy (CAA) and blood‐brain barrier (BBB) dysregulation are prominent features in the majority of Alzheimer's disease (AD) cases.
Chia-Chen Liu, Yu Yamazaki, M. Heckman, Yuka A. Martens, Lin Jia, Akari Yamazaki, N. Diehl, Jing Zhao, Na Zhao, M. DeTure, Mary D. Davis, Lindsey M. Felton, Wenhui Qiao, Yonghe Li, Hongmei Li, Yuan Fu, Na Wang, Melissa C. Wren, Tomonori Aikawa, Marie-Louise Holm, Hiroshi Oue, Cynthia Linares, M. Allen, M. Carrasquillo, M. Murray, R. Petersen, N. Ertekin-Taner, D. Dickson, T. Kanekiyo, G. Bu   +29 more
semanticscholar   +1 more source

Cerebral Amyloid Angiopathy and Intracerebral Haemorrhage

Advances in Clinical Neuroscience & Rehabilitation, 2016
Cerebral amyloid angiopathy (CAA) is increasingly recognised, particularly as a cause of intracerebral haemorrhage and dementia. CAA may present to the clinical neurologist in a range of circumstances, including inpatient or outpatient general neurology (
David Werring, Gargi Banerjee
doaj   +1 more source

Predicting Tau Accumulation in Cerebral Cortex with Multivariate MRI Morphometry Measurements, Sparse Coding, and Correntropy [PDF]

arXiv, 2021
Biomarker-assisted diagnosis and intervention in Alzheimer's disease (AD) may be the key to prevention breakthroughs. One of the hallmarks of AD is the accumulation of tau plaques in the human brain. However, current methods to detect tau pathology are either invasive (lumbar puncture) or quite costly and not widely available (Tau PET). In our previous
arxiv  

A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy

Journal of Neuroinflammation, 2020
Background Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid. The mechanisms underlying the contribution of CAA to neurodegeneration are not currently understood.
Xavier Taylor, Pablo Cisternas, Y. You, Yin-jun You, S. Xiang, Yamil Marambio, Jie Zhang, R. Vidal, Cristian A. Lasagna-Reeves   +8 more
semanticscholar   +1 more source