Results 51 to 60 of about 42,785 (261)

A practical approach to the management of cerebral amyloid angiopathy

International Journal of Stroke, 2020
Cerebral amyloid angiopathy is a common small vessel disease in the elderly involving vascular amyloid-β deposition. Cerebral amyloid angiopathy is one of the leading causes of intracerebral hemorrhage and a significant contributor to age-related ...
M. Kozberg, V. Perosa, M. Gurol, Susanne J. van Veluw   +3 more
semanticscholar   +1 more source

An autopsy case of amyloid β-related angiitis with cognitive impairment, multiple infarcts and subcortical hemorrhage

Human Pathology: Case Reports, 2018
A 76-year-old female presented with cognitive impairment and multiple brain infarcts and died of massive subcortical cerebral hemorrhage. A premortem clinical diagnosis was not possible.
Takahiro Watanabe, MD, PhD, Shinichiro Ukon, MD, Takako Kihara, MD, Yoshi-Hiro Ide, MD, PhD, Shohei Matsuo, MD, Yuka Hayashi, MD, Shuhei Kasama, MD, PhD, Hiroo Yoshikawa, MD, PhD, Yuki Okano, Chiaki Uchida, Masahiro Yamamoto, Hiroyuki Hao, MD, PhD, Akio Kimura, MD, PhD, Seiichi Hirota, MD, PhD, Yoshitane Tsukamoto, MD, PhD   +14 more
doaj   +1 more source

Bicine promotes rapid formation of β-sheet-rich amyloid-β fibrils.

PLoS ONE, 2020
Fibrillar aggregates of amyloid-β (Aβ) are the main component of plaques lining the cerebrovasculature in cerebral amyloid angiopathy. As the predominant Aβ isoform in vascular deposits, Aβ40 is a valuable target in cerebral amyloid angiopathy research ...
Hye Yun Kim, HeeYang Lee, Jong Kook Lee, Hyunjin Vincent Kim, Key-Sun Kim, YoungSoo Kim   +5 more
doaj   +1 more source

Parenchymal and vascular Aβ-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease [PDF]

, 2008
The deposition of the amyloid β-protein (Aβ) is one of the pathological hallmarks of Alzheimer's disease (AD). Aβ-deposits show the morphology of senile plaques and cerebral amyloid angiopathy (CAA). Senile plaques and vascular Aβ-deposits occur first in
Braak, Heiko, Griffin, W. Sue T., Thal, Dietmar Rudolf   +2 more
core   +1 more source

Cerebral tau pathology in cerebral amyloid angiopathy

Brain Communications
Tau, a hallmark of Alzheimer’s disease, is poorly characterized in cerebral amyloid angiopathy. We aimed to assess the clinico-radiological correlations between tau positron emission tomography scans and cerebral amyloid angiopathy.
Hsin-Hsi Tsai, Chia-Ju Liu, Bo-Ching Lee, Ya-Fang Chen, R. Yen, J. Jeng, Li-Kai Tsai   +6 more
semanticscholar   +1 more source

Anti-Aβ Autoantibodies in Amyloid Related Imaging Abnormalities (ARIA): Candidate Biomarker for Immunotherapy in Alzheimer’s Disease and Cerebral Amyloid Angiopathy [PDF]

, 2015
Amyloid-related imaging abnormalities (ARIA) represent the major severe side effect of amyloid-beta (Aβ) immunotherapy for Alzheimer’s disease (AD).
Fabrizio Piazza, Jacopo C. DiFrancesco, Martina Longoni   +2 more
core   +1 more source

Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease [PDF]

, 2010
Because regional blood flow increases in association with the increased metabolic demand generated by localised increases in neural activity, functional imaging researchers often assume that changes in blood flow are an accurate read-out of changes in ...
Attwell, D., Hall, C.N., Hamilton, N.B.
core   +3 more sources

Spontaneous and Drug-Induced Amyloid-Related Imaging Abnormalities: Overlaps, Divergences, and Clinical Implications Across a Continuum Between Alzheimer’s Disease and Cerebral Amyloid Angiopathy

Biomolecules
Background: Amyloid-related imaging abnormalities (ARIA) have gained significance in the context of anti-amyloid therapies (AATs), exhibiting clinical and radiological manifestations that overlap with Cerebral Amyloid Angiopathy-related inflammation (CAA-
Marialuisa Zedde, Mattia Losa, Elena Grisafi, Davide D. Lucia, Ilaria Gandoglia, Massimo Del Sette, Matteo Pardini, Luca Roccatagliata, Rosario Pascarella, Fabrizio Piazza   +9 more
doaj   +1 more source

Synergistic effects of longitudinal amyloid and vascular changes on lobar microbleeds [PDF]

, 2016
OBJECTIVE: To determine whether amyloid and hypertensive cerebral small vessel disease (hCSVD) changes synergistically affect the progression of lobar microbleeds in patients with subcortical vascular mild cognitive impairment (svMCI).
Choe, YS, Jung, N-Y, Kim, HJ, Kim, JS, Kim, S, Kim, YJ, Kim, YJ, Kwak, K-C, Lee, J-H, Lee, JM, Lee, K-H, Moon, SH, Na, DL, Park, J-H, Seo, SW, Werring, DJ, Woo, S-Y   +16 more
core   +1 more source

Understanding the Pathophysiology of Cerebral Amyloid Angiopathy

International Journal of Molecular Sciences, 2020
Cerebral amyloid angiopathy (CAA), one of the main types of cerebral small vessel disease, is a major cause of spontaneous intracerebral haemorrhage and an important contributor to cognitive decline in elderly patients. Despite the number of experimental
L. Gatti, F. Tinelli, E. Scelzo, F. Arioli, G. Di Fede, L. Obici, L. Pantoni, G. Giaccone, P. Caroppo, E. Parati, A. Bersano   +10 more
semanticscholar   +1 more source