Results 61 to 70 of about 42,785 (261)

Neuropathological correlates of cortical superficial siderosis in cerebral amyloid angiopathy

Brain : a journal of neurology, 2020
Cortical superficial siderosis (cSS) is an established hemorrhagic neuroimaging marker of cerebral amyloid angiopathy (CAA) and emerging as a strong independent risk factor for future lobar intracerebral hemorrhage.
Susanne J. van Veluw, A. Charidimou, M. Frosch, S. Greenberg   +3 more
semanticscholar   +1 more source

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Cerebral Amyloid Angiopathy-Related Inflammation following Multiple Cancers and Chemotherapies

Case Reports in Neurology, 2022
Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare autoimmune encephalopathy of aging caused by an autoantibody immune response against Aβ protein deposited in the brain of older adults affected by cerebral amyloid angiopathy (CAA) and ...
Christophe Severijns, Emilie Drion, Elettra Bianchi, Pierre Maquet   +3 more
doaj   +1 more source

Cerebral Amyloid Angiopathy and Intracerebral Haemorrhage

Advances in Clinical Neuroscience & Rehabilitation, 2016
Cerebral amyloid angiopathy (CAA) is increasingly recognised, particularly as a cause of intracerebral haemorrhage and dementia. CAA may present to the clinical neurologist in a range of circumstances, including inpatient or outpatient general neurology (
David Werring, Gargi Banerjee
doaj   +1 more source

Vascular dementia: Current concepts and nomenclature harmonization. [PDF]

, 2012
Several types of cerebrovascular lesions are associated with cognitive decline, but the role of each type in dementia manifestation has yet to be determined.
Grinberg, Lea Tenenholz
core  

Clinical–Radiological Spectrum of Cerebral Amyloid Angiopathy‐Related Inflammation

Annals of Neurology, EarlyView.
Objective To identify clinical and radiological features of cerebral amyloid angiopathy‐related inflammation (CAA‐ri), and compare these features with those of sporadic CAA, to improve the understanding, diagnosis, and clinical care of CAA‐ri. Methods We retrospectively reviewed routine clinical data from 37 patients with CAA‐ri and 158 patients with ...
Larysa Panteleienko, Gargi Banerjee, Dermot Mallon, Kitti Thiankhaw, Rupert Oliver, Victoria Harvey, Gareth Ambler, Michael Zandi, Hans Rolf Jäger, David J. Werring   +9 more
wiley   +1 more source

Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy

Journal of Alzheimer's Disease, 2020
Background: There is limited data on cerebrospinal fluid (CSF) biomarkers in sporadic amyloid-β (Aβ) cerebral amyloid angiopathy (CAA). Objective: To determine the profile of biomarkers relevant to neurodegenerative disease in the CSF of patients with ...
G. Banerjee, G. Ambler, A. Keshavan, R. Paterson, M. Foiani, J. Toombs, A. Heslegrave, J. Dickson, F. Fraioli, A. Groves, M. Lunn, Nick C Fox, H. Zetterberg, J. Schott, D. Werring   +14 more
semanticscholar   +1 more source

Recent Insights Into Alzheimer's Disease: Advances in Pathophysiology and Therapeutic Strategies

Brain Health, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a complex neurodegenerative disorder driven by interplay among amyloid‐β (Aβ) plaques, tau neurofibrillary tangles, inflammation and comorbid pathologies. Recent advances in biomarkers and therapeutic approvals have reshaped our understanding of its pathophysiology and treatment landscape.
Jiong Shi, Jeffery Cummings, Jacques Touchon, Bruno Vellas   +3 more
wiley   +1 more source

Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer’s disease mouse model

Acta Neuropathologica Communications, 2020
Cerebral amyloid angiopathy (CAA), defined as the accumulation of amyloid-beta (Aβ) on the vascular wall, is a major pathology of Alzheimer’s disease (AD) and has been thought to be caused by the failure of Aβ clearance.
Shinheun Kim, J. Ahn, Hyunwoo Yang, Peter Lee, G. Koh, Y. Jeong   +5 more
semanticscholar   +1 more source