Results 61 to 70 of about 32,043 (291)

Substantial Doubt Remains about the Efficacy of Anti-Amyloid Antibodies [PDF]

arXiv, 2023
Alzheimer's disease (AD) is a prevalent, progressive, and ultimately fatal neurodegenerative disorder that is defined pathologically by the accumulation of amyloid plaques and tau neurofibrillary tangles in the brain. There remains an unmet need for therapies that can halt or slow the course of AD. To address this need, the FDA has provided a mechanism,
arxiv  

The Role of Basement Membranes in Cerebral Amyloid Angiopathy

Frontiers in Physiology, 2020
Dementia is a neuropsychiatric syndrome characterized by cognitive decline in multiple domains, often leading to functional impairment in activities of daily living, disability, and death.
M. Howe, L. McCullough, A. Urayama
semanticscholar   +1 more source

Occurrence, Risk Factors, and Prognosis of Acute Cerebral Microinfarcts in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cerebral small vessel disease in adults. This study investigates the occurrence, risk factors, and prognosis of acute cerebral microinfarcts (ACMIs) in patients with CADASIL.
Xuejiao Men, Hui Li, Zhuoxin Guo, Bin Qin, Hengfang Ruan, Ruipeng Cai, Bingjun Zhang, Aimin Wu, Lei Wei, Yongqiang Dai, Haiyan Li, Zhengqi Lu   +11 more
wiley   +1 more source

Cerebral amyloid angiopathy related inflammation: An under recognized but treatable complication of cerebral amyloid angiopathy

Radiology Case Reports, 2023
Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a subset of cerebral amyloid angiopathy (CAA) causing a reversible encephalopathy characterized by seizures and focal neurological deficit.
Alexander Berry-Noronha, MBBS, Luke Bonavia, MBBS, Tia Smith, MBBS, Ramesh Sahathevan, PhD   +3 more
doaj  

Hypertension-Related Cerebral Microbleeds

Case Reports in Neurology, 2020
Hypertension and cerebral amyloid angiopathy are the most common causes of cerebral microbleeds. The pattern of microbleeds on T2*-weighted gradient echo sequence of magnetic resonance imaging of the brain can be indicative of the etiology of ...
Sujan T. Reddy, Sean I. Savitz
doaj   +1 more source

Association of TDP-43 proteinopathy, cerebral amyloid angiopathy, and Lewy bodies with cognitive impairment in individuals with or without Alzheimer’s disease neuropathology

Scientific Reports, 2020
Alzheimer’s disease patients typically present with multiple co-morbid neuropathologies at autopsy, but the impact of these pathologies on cognitive impairment during life is poorly understood.
David X. Thomas, Sumali Bajaj, K. McRae-McKee, C. Hadjichrysanthou, Roy M. Anderson, J. Collinge   +5 more
semanticscholar   +1 more source

Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts

Advanced Science, EarlyView.
Jin et al. investigate the neurovascular impact of microinfarcts, revealing transient neural suppression with minimal cell death and recovery linked to vascular remodeling. Fast‐spiking interneurons exhibit reduced excitability, whereas regular‐spiking neurons showed increased bursting activity. Disruptions in low‐gamma phase locking suggest persistent
Yifu Jin, Fei He, Haad Rathore, Yingchu Sun, Jia‐ao Zhang, Xinyu Li, Rongkang Yin, Hanlin Zhu, Chong Xie, Lan Luan   +9 more
wiley   +1 more source

Cerebral amyloid angiopathy (case report)

Анналы клинической и экспериментальной неврологии, 2017
Cerebral amyloid angiopathy (CAA) is characterized by -amyloid deposition in cortical and leptomeningeal arteries of small and medium size that disturbs normal structure of arterial wall.
L. A. Dobrynina, L. A. Kalashnikova, R. N. Konovalov, A. S. Kadykov   +3 more
doaj   +1 more source

Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD): Executive summary of recommendations for primary care

Alzheimer's &Dementia, EarlyView.
Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri, Bradford C. Dickerson, Carolyn Clevenger, Jason Karlawish, David Knopman, Pei‐Jung Lin, Mary Norman, Chiadi Onyike, Mary Sano, Susan Scanland, Maria Carrillo   +10 more
wiley   +1 more source

Cerebral amyloid angiopathy

Indian Journal of Radiology and Imaging, 2006
Cerebral amyloid angiopathy (CAA) is a very rare entity. This is an age related disease and is not a manifestation of systemic amyloidosis in any of its forms. Sporadic cases are most common, though hereditary cases do exist. Alzheimer's disease predispose to CAA.
Bkd Prasad, GS Kejriwal, SN Sahu
openaire   +2 more sources