Results 81 to 90 of about 28,628 (268)

Alzheimer's disease and mixed pathologies as a hidden contributor to fatal hypothermia: A large‐scale forensic autopsy‐based study

Brain Pathology, EarlyView.
We investigated neuropathological manifestations of hypothermia in 168 cases. Patients aged 65 years or more constituted 80% of the total cohort. Alzheimer's disease was the most common comorbidity, affecting 40% of all patients. Abstract There is a paucity of autopsy‐based studies providing detailed neuropathological characteristics of fatal ...
Shojiro Ichimata, Koji Yoshida, Ryo Tanaka   +2 more
wiley   +1 more source

Advances of cerebral amyloid angiopathy and related cognitive impairment

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Cerebral amyloid angiopathy (CAA) is a common cerebral small vessel disease(cSVD) in clinic. It is characterized by the deposition of amyloid β-protein (Aβ) in the cerebral vascular wall, including small and medium arteries of pia mater and cortex and ...
Zhen ZHEN, Yan⁃jun GUO
doaj   +1 more source

Vessel‐associated microglia are differentially activated and distributed in relation to systemic infection and Alzheimer's disease

Brain Pathology, EarlyView.
This post‐mortem study revealed an increased density of vessel‐associated microglia (VAM) in the temporal lobe in systemic infection and Alzheimer's disease. VAM density was related to brain cytokine levels and markers of cerebrovascular dysfunction and BBB leakage indicating that activated VAM contributes to neurovascular injury in Alzheimer's disease.
Oliver Milner, Robert A. Fisher, Daniel J. Asby, Stephen Cross, Delphine Boche, J. Scott Miners   +5 more
wiley   +1 more source

Central nervous system involvement in cardiac amyloidosis: Redefining the heart‐brain axis

European Journal of Clinical Investigation, EarlyView.
Central nervous system involvement in cardiac amyloidosis. Amyloidosis is a systemic disease that can directly affect the central nervous system. Furthermore, the amyloid cardiomyopathy can indirectly affect the central nervous system by inducing systemic hypoperfusion and increasing the risk of acute ischaemic stroke.
Domenico Mario Giamundo, Giuliano Cassataro, Stefano Ministrini, Simon F. Stämpfli   +3 more
wiley   +1 more source

Clusterin/Apolipoprotein J immunoreactivity is associated with white matter damage in cerebral small vessel diseases [PDF]

, 2015
Aim: Brain clusterin is known to be associated with the amyloid‐β deposits in Alzheimer's disease (AD). We assessed the distribution of clusterin immunoreactivity in cerebrovascular disorders, particularly focusing on white matter changes in small vessel
Borjesson-Hanson, A, Chen, A, Craggs, L, Deramecourt, V, Hagel, C, Kalaria, RN, Kalimo, H, Kuhlenbaeumer, G, Oakley, AE, Slade, JY, Taylor, J, Viitanen, M   +11 more
core   +1 more source

The interacting etiologies of hippocampal sclerosis in epilepsy: A scoping review

Epilepsia, EarlyView.
Abstract According to the International League Against Epilepsy classification, mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS) is considered an epilepsy syndrome. Several etiologies may precede HS, but there is little overview in the literature about these etiologies.
Boris Deleu, Jules Jeuris, Wim Van Paesschen   +2 more
wiley   +1 more source

Research progress of cerebral amyloid angiopathy associated with inflammation

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Cerebral amyloid angiopathy associated with inflammation (CAA⁃I) is a rare subtype of cerebral amyloid angiopathy (CAA), and is increasingly recognized by neurologists. CAA⁃Iischaracterized by the pathological hallmarks of both CAA and vasculitis.
Wen⁃hao ZHANG, Ran LIU, Yi⁃ning HUANG   +2 more
doaj  

Cerebral Amyloid Angiopathy Related Inflammation: A Single-Center Case Series Analysis. [PDF]

Brain Sci
Ali SZ, Alley H, Johnson J, Sirvisetty H, Sowell M, Glynn A, Hedera P.   +6 more
europepmc   +3 more sources

Applying the Canadian Head CT Criteria to Older Adults Seen in the Emergency Department After a Fall

Journal of the American Geriatrics Society, EarlyView.
Prevalence of intracranial bleeding in adults based on the CCTHR criteria. ABSTRACT Background The Canadian CT Head Rule (CCTHR) is validated in adults who hit their head and experience loss of consciousness, amnesia, or disorientation. There is less evidence to guide brain imaging when the fall history is unclear.
Geoff Kerr, Allie Chown, Mathew Mercuri, Natasha Clayton, Éric Mercier, Judy Morris, Rebecca Jeanmonod, Debra Eagles, Catherine Varner, David Barbic, Sameer Parpia, Ian M. Buchanan, Mariyam Ali, Yoan K. Kagoma, Ashkan Shoamanesh, Paul Engels, Sunjay Sharma, Andrew Worster, Shelley McLeod, Marcel Émond, Ian Stiell, Alexandra Papaioannou, Kerstin de Wit   +22 more
wiley   +1 more source

Association of angiitis of central nervous system, cerebral amyloid angiopathy, and Alzheimer's disease: Report of an autopsy case [PDF]

, 2008
The association of angiitis of central nervous system (ACNS) with cerebral amyloid angiopathy (CAA) suggests a physiopathological relationship between these two affections. Few cases are reported in patients with Alzheimer’s disease (AD).
C. Annweiler, C. Hommet, C. Lavigne, G. Berrut, J.P. Saint-André, M. Paccalin, O. Beauchet   +6 more
core   +1 more source