Results 81 to 90 of about 32,043 (291)
Advances of cerebral amyloid angiopathy and related cognitive impairment
Chinese Journal of Contemporary Neurology and Neurosurgery, 2019 Cerebral amyloid angiopathy (CAA) is a common cerebral small vessel disease(cSVD) in clinic. It is characterized by the deposition of amyloid β-protein (Aβ) in the cerebral vascular wall, including small and medium arteries of pia mater and cortex and ...
Zhen ZHEN, Yan⁃jun GUO
doaj +1 more source
Analyzing the Spatiotemporal Interaction and Propagation of ATN Biomarkers in Alzheimer's Disease using Longitudinal Neuroimaging Data [PDF]
arXiv, 2021 Three major biomarkers: beta-amyloid (A), pathologic tau (T), and neurodegeneration (N), are recognized as valid proxies for neuropathologic changes of Alzheimer's disease. While there are extensive studies on cerebrospinal fluids biomarkers (amyloid, tau), the spatial propagation pattern across brain is missing and their interactive mechanisms with ...
arxiv
Aging Cell, Volume 24, Issue 4, April 2025.This study identifies a significant association between accelerated biological aging, measured by clinical biomarker‐based KDM‐BA and PhenoAge accelerations, and an increased risk of stroke and its subtypes. The combination of accelerated biological aging with high genetic risk helps identify high‐risk populations on stroke development.
Xuening Zhang +8 more
wiley +1 more source
Reduction of Alzheimer's disease beta-amyloid pathology in the absence of gut microbiota [PDF]
arXiv, 2015 Alzheimer's disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number of brain disorders, its impact on Alzheimer's disease is not known.
arxiv
Insights into the variability of nucleated amyloid polymerization by a minimalistic model of stochastic protein assembly [PDF]
, 2015 Self-assembly of proteins into amyloid aggregates is an important biological phenomenon associated with human diseases such as Alzheimer's disease. Amyloid fibrils also have potential applications in nano-engineering of biomaterials. The kinetics of amyloid assembly show an exponential growth phase preceded by a lag phase, variable in duration as seen ...
arxiv +1 more source
Aging Cell, Volume 24, Issue 4, April 2025.We sought to identify the cerebrospinal fluid protein (CSF) changes that are associated with the APOE4 genetic variant to better understand the vulnerability of APOE4 carriers to progress to Alzheimer's disease (AD) with age. To do this, we used machine learning and enrichment analyses to analyze 6082 proteins in the CSF of cognitively normal, mild ...
Artur Shvetcov +8 more
wiley +1 more source
Türk Nöroloji Dergisi, 2009 Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid beta-peptides (Ab) in the walls of leptomeningeal arteries, arterioles, and veins.
Mahmut Edip Gürol
doaj
What drives amyloid molecules to assemble into oligomers and fibrils? [PDF]
, 2010 We develop a general theory for three states of equilibrium of amyloid peptides: the monomer, oligomer, and fibril. We assume that the oligomeric state is a disordered micelle-like collection of a few peptide chains held together loosely by hydrophobic interactions into a spherical hydrophobic core.
arxiv +1 more source
The prevalence of chronic traumatic encephalopathy in a historical epilepsy post‐mortem collection
Brain Pathology, Volume 35, Issue 3, May 2025.In an archival epilepsy post‐mortem collection from last century, chronic traumatic encephalopathy identified in 15.7% was associated with traumatic brain injury. Alzheimer's disease neuropathology change was increased in late‐onset epilepsy but in 8% of cases with severe epilepsy there was no tau pathology found. Abstract Previous post‐mortem epilepsy
Maritchka Ryniejska +4 more
wiley +1 more source
Cerebral Amyloid Angiopathy: A Systematic Review [PDF]
Journal of Clinical Neurology, 2011 Cerebral amyloid angiopathy (CAA) is a disorder characterized by amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and less often capillaries and veins of the central nervous system. CAA occurs mostly as a sporadic condition in the elderly, its incidence associating with advancing age.
Steven M. Greenberg +3 more
openaire +3 more sources