Results 81 to 90 of about 8,369 (198)

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Multi‐Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential endothelial‐neural signaling networks that maintain region‐specific intermediate progenitors during hindbrain development.
Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, John Guo, Kai Cheng, Luke Daniel Ofria, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E Badr, Annie Kathuria   +10 more
wiley   +1 more source

Angioneogenese in cerebralen Arteriovernösen Malformationen [PDF]

, 2004
Arteriovenöse Malformationen werden in der Literatur meistens als angeborene und statische Gefäßmissbildungen beschrieben. Neuere Arbeiten und Erkenntnisse legen jedoch eine dynamische Biologie dieser Malformationen nahe.
Battenberg, Elmar, Sure, U. (PD Dr. med.)   +1 more
core   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, Volume 3, Issue 5, September 2025.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source

Developing a Randomised Efficacy PREcision medicine Platform trial design for Cavernomas: the CARE PREP study

Efficacy and Mechanism Evaluation
Background Symptomatic cerebral cavernous malformations are a rare sporadic or familial disease, which may cause haemorrhagic strokes or epileptic seizures.
Rustam Al-Shahi Salman, Kasia Adamczuk, Richard A Parker, Christopher J Weir, Roberto Latini, Helen Kim, David White, Helen Evans, Jana Bergholtz, Cornelia Lee, Carlos Casaus   +10 more
doaj   +1 more source

Unexpected distribution of KRIT1 inside the nucleus: new insight in a complex molecular pathway

European Journal of Histochemistry, 2014
KRIT1 is an 84kDa protein that lacks any relevant catalytic domains, associated with the cerebral cavernous malformation disease. We have investigated by means of ultrastructural immunocytochemistry the nuclear distribution of KRIT1 in different cell ...
S. Marzo, V. Galimberti, M. Biggiogera
doaj   +1 more source

Ventriculoperitoneal shunt failure and infection: a retrospective review at Queen Mary Hospital [PDF]

, 2008
Oral Poster Paper IBACKGROUND: Ventriculoperitoneal shunting is a commonly performed procedure for diversion of cerebrospinal fluid. However shunt failure and infection results in significant morbidity and repeated operations.
Leung, G, Wong, PHD
core  

Metabolic Factors Related to Interpersonal Dysfunction in Acromegaly: A Nationwide Cross‐Sectional Study in China

CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.
Metabolic and physical factors—specifically frontal bossing, cardiovascular comorbidities, and elevated preoperative GH levels—are independent predictors of severe interpersonal dysfunction in Chinese patients with acromegaly. These findings underscore the need for integrating systematic psychosocial screening into routine neuroendocrine management to ...
Shashi Kiran Tagilapalli, Zongming Wang, Yuechu Lucinda Lu, Guofeng Zhang, Weijie Su, Zhentian Wu, Jiaming Wang, Qing Rao, Haijun Wang, Dongsheng He, Yonggao Mou, Shun Yao, Yanmei Tie, Wenli Chen   +13 more
wiley   +1 more source

Routinely Performed Serial Follow-Up Imaging in Asymptomatic Patients With Multiple Cerebral Cavernous Malformations Has No Influence on Surgical Decision Making

Frontiers in Neurology, 2018
Background: The best strategy to perform follow-up of patients with multiple cerebral cavernous malformations (mCCM) is unclear due to the unpredictable clinical course. Still, serial radiological follow-up is often performed.
Julia Velz, Julia Velz, Martin Nikolaus Stienen, Martin Nikolaus Stienen, Marian Christoph Neidert, Marian Christoph Neidert, Yang Yang, Yang Yang, Luca Regli, Luca Regli, Oliver Bozinov, Oliver Bozinov   +11 more
doaj   +1 more source

Cerebral Cavernous Malformations [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2000
I, Fleetwood, W, Hu, M, Hudon
openaire   +2 more sources

Inherited cavernous malformations of the central nervous system: clinical and genetic features in 19 Swiss families [PDF]

, 2018
Cavernous malformations (CCMs) are benign, well-circumscribed, and mulberry-like vascular malformations that may be found in the central nervous system in up to 0.5% of the population. Cavernous malformations can be sporadic or inherited.
Andermann, F., Baumann, C., Baumgartner, R., Bonassin, F., Georgiadis, D., Graeni, C., Merlo, A., Rouleau, G., Siegel, A., Stepper, F., Sturzenegger, M., Verlaan, D.   +11 more
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