Results 231 to 240 of about 602,933 (343)

Organizational Principles of the Primate Cerebral Cortex at the Single-Cell Level. [PDF]

Adv Sci (Weinh)
Chen R, Nie P, Ma L, Wang GZ.
europepmc   +1 more source

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

Copy number variants and the tangential expansion of the cerebral cortex. [PDF]

Nat Commun
Liao Z, Kumar K, Kopal J, Huguet G, Saci Z, Jean-Louis M, Pausova Z, Jurisica I, Bearden CE, IMAGEN Consortium, 16p11.2 European Consortium, Jacquemont S, Paus T.   +12 more
europepmc   +1 more source

Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact

Advanced Science, EarlyView.
Multi‐omics profiling of stroke patients exposes systemic molecular fingerprints of immune activation, oxidative stress and metabolic collapse. Complement and coagulation cascade, and cholesterol metabolism emerge as shared functional hallmarks of plasma migrasomes in stroke patients and migrasomes isolated from experimental stroke mice.
Huifen Zhou, Yingying Zhang, Peng Zhou, Haofang Wan, Lingling Li, Bin Xu, Yuping Wan, Yingming Song, Yi Kang, Hongbo Zhang, Min Shi, Qun Hou, Jiehong Yang, Chen Ding, Wei Fu, Buchang Zhao, Haitong Wan   +16 more
wiley   +1 more source

An integrative analysis of cell-specific transcriptomics and nuclear proteomics of sleep-deprived mouse cerebral cortex. [PDF]

Sci Rep
Jha PK, Valekunja UK, Reddy AB.
europepmc   +1 more source

Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation

Advanced Science, EarlyView.
Photoacoustic microscopy (PAM) is a powerful biomedical imaging tool renowned for its non‐invasiveness and high resolution. This review synthesizes recent technological advances and highlights their broad applications from cellular and organ‐level to whole‐animal imaging.
Tingting Wang, Jiali Chen, Liming Nie, Honghui Li   +3 more
wiley   +1 more source

Mirror effect of genomic deletions and duplications on cognitive ability across the human cerebral cortex

Kumar K, Kazem S, Huguet G, Engchuan W, Kopal J, Renne T, Shanta O, Thiruvahindrapuram B, MacDonald J, Mollon J, Schultz LM, Knowles EEM, Porteous D, Davies G, Redmond P, Harris S, Cox S, Schumann G, Pausova Z, Greenwood C, Paus T, Scherer S, Almasy L, Sebat J, Glahn D, Dumas G, Jacquemont S.   +26 more
europepmc   +1 more source

Time-varying synergy/redundancy dominance in the human cerebral cortex. [PDF]

J Phys Complex
Pope M, Varley TF, Grazia Puxeddu M, Faskowitz J, Sporns O.   +4 more
europepmc   +1 more source

Research Progress on Idebenone in Neurodegenerative Diseases

AGING MEDICINE, EarlyView.
The study not only summarizes the biological properties of Idebenone (IDE), including its role in improving mitochondrial function and antioxidative stress, but also explores its clinical research progress in various neurodegenerative diseases, providing a new perspective for the treatment of these disorders.
Yanqing Zhang, Yanhong Ren, Xiaoran Zhu, Tianhao Liu, Rundong Han, Yuqing Fang, Zhangning Zhao, Fei Mao, Yalin Wang, Xian Li, Xiuhua Li   +10 more
wiley   +1 more source

Public Health. [PDF]

Alzheimers Dement
Morgan RK, Matei EK, Ishikawa T, Pan J, Polemi KM, Dolinoy DC, Bakulski KM, Colacino JA.   +7 more
europepmc   +1 more source