Results 51 to 60 of about 1,609,795 (412)

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

Nature, 2019
Experimental models of the human brain are needed for basic understanding of its development and disease1. Human brain organoids hold unprecedented promise for this purpose; however, they are plagued by high organoid-to-organoid variability2,3.
Silvia Velasco, Amanda J. Kedaigle, Sean K. Simmons, A. Nash, Marina Rocha, Giorgia Quadrato, B. Paulsen, Lan Nguyen, Xian Adiconis, A. Regev, J. Levin, P. Arlotta   +11 more
semanticscholar   +1 more source

Subcellular organization of UBE3A in human cerebral cortex. [PDF]

, 2018
BackgroundLoss of UBE3A causes Angelman syndrome, whereas excess UBE3A activity appears to increase the risk for autism. Despite this powerful association with neurodevelopmental disorders, there is still much to be learned about UBE3A, including its ...
Burette, Alain C, Chang, Edward F, Judson, Matthew C, Li, Alissa N, Philpot, Benjamin D, Seeley, William W, Weinberg, Richard J   +6 more
core   +3 more sources

The organization of the human cerebral cortex estimated by intrinsic functional connectivity.

Journal of Neurophysiology, 2011
Information processing in the cerebral cortex involves interactions among distributed areas. Anatomical connectivity suggests that certain areas form local hierarchical relations such as within the visual system. Other connectivity patterns, particularly
B. T. T. Yeo, Fenna M. Krienen, Jorge Sepulcre, Jorge Sepulcre, M. Sabuncu, M. Sabuncu, D. Lashkari, Marisa O. Hollinshead, Marisa O. Hollinshead, J. Roffman, J. Smoller, Lilla Zöllei, J. Polimeni, B. Fischl, B. Fischl, Hesheng Liu, Randy L. Buckner   +16 more
semanticscholar   +1 more source

A Sip of GABA for the Cerebral Cortex [PDF]

Neuron, 2013
Cortical and striatal interneurons are both generated within the ventral telencephalon, but their migratory journey takes them to very different destinations. Two articles in this issue (van den Berge et al., 2013; McKinsey et al., 2013) add an important molecular component to our understanding of how, during development, interneurons reach the ...
Simona Lodato, Paola Arlotta, Giulio Srubek Tomassy   +2 more
openaire   +5 more sources

The pernicious danger of cortical brain maps [PDF]

arXiv, 2022
The parcellation of the primate cerebral cortex into numbered regions, based on cytoarchitecture, began with the pioneering research of neuroanatomist Kobrinian Brodmann. While the borders between regions have changed somewhat, and in some cases continue to be disputed, the idea of dividing the cortex into distinct numbered areas has become central to ...
arxiv  

Compensatory recombination phenomena of neurological functions in central dysphagia patients

Neural Regeneration Research, 2015
We speculate that cortical reactions evoked by swallowing activity may be abnormal in patients with central infarction with dysphagia. The present study aimed to detect functional imaging features of cerebral cortex in central dysphagia patients by using
Xiao-dong Yuan, Li-fu Zhou, Shu-juan Wang, Yan-sheng Zhao, Xiao-jie Wang, Li-li Zhang, Shou-hong Wang, Ya-jie Zhang, Li Chen   +8 more
doaj   +1 more source

Loss of GABAergic cortical neurons underlies the neuropathology of Lafora disease [PDF]

, 2014
BACKGROUND: Lafora disease is an autosomal recessive form of progressive myoclonic epilepsy caused by defects in the EPM2A and EPM2B genes. Primary symptoms of the pathology include seizures, ataxia, myoclonus, and progressive development of severe ...
Agis Balboa, Roberto Carlos, Ortolano, Saida, Spuch Calvar, Carlos, Vieitez González, Irene   +3 more
core   +1 more source

New insights into the development of the human cerebral cortex

Journal of Anatomy, 2019
The cerebral cortex constitutes more than half the volume of the human brain and is presumed to be responsible for the neuronal computations underlying complex phenomena, such as perception, thought, language, attention, episodic memory and voluntary ...
Z. Molnár, G. Clowry, N. Šestan, Ayman Alzu’bi, Trygve E Bakken, R. Hevner, P. Hüppi, I. Kostović, P. Rakic, E. Anton, D. Edwards, P. Garcez, A. Hoerder-Suabedissen, A. Kriegstein   +13 more
semanticscholar   +1 more source

Microcolumns in the cerebral cortex [PDF]

Proceedings of the National Academy of Sciences, 2000
Neuroanatomists from Cajal on (1) have searched in the cerebral cortex for units of structural organization that transcend the laminar pattern visible even to the untutored eye in Nissl-stained preparations. Many have commented on the vertical column-like arrays of cell bodies running orthogonal to the horizontal laminae that are particularly ...
openaire   +3 more sources

Gyrification of the cerebral cortex requires FGF signaling in the mammalian brain

eLife, 2017
Although it has been believed that the evolution of cortical folds was a milestone, allowing for an increase in the number of neurons in the cerebral cortex, the mechanisms underlying the formation of cortical folds are largely unknown.
Naoyuki Matsumoto, Yohei Shinmyo, Yoshie Ichikawa, Hiroshi Kawasaki   +3 more
doaj   +1 more source