Results 111 to 120 of about 1,244,067 (429)

TAK-242, an antagonist for Toll-like receptor 4, protects against acute cerebral ischemia/reperfusion injury in mice

Journal of Cerebral Blood Flow and Metabolism, 2015
Toll-like receptor 4 (TLR4) contributes to cerebral ischemia/reperfusion (I/R) injury and is a potential target for the treatment of ischemic stroke.
F. Hua, Huiling Tang, Jun Wang, M. Prunty, Xiaodong Hua, I. Sayeed, D. Stein   +6 more
semanticscholar   +1 more source

(Apo)Lipoprotein Profiling with Multi‐Omics Analysis Identified Medium‐HDL‐Targeting PSRC1 with Therapeutic Potential for Coronary Artery Disease

Advanced Science, EarlyView.
Lipid content in medium high‐density lipoprotein (HDL) particles, particularly cholesteryl esters, is identified as causally protective of atherosclerosis, and further ASCVD. Evidence from multi‐omics layers of data consistently supports PSRC1 with therapeutic potential for coronary artery disease (CAD), but not ischemic stroke.
Yingmei Li, Sihan Wang, Ling Liu, Hao Cai, Yacan Huang, Mingjing Gao, Xiaogang Zhang, Qingqing Wu, Gaokun Qiu   +8 more
wiley   +1 more source

Health‐related quality of life following total minimally invasive, hybrid minimally invasive or open oesophagectomy: a population‐based cohort study

BJS (British Journal of Surgery), EarlyView., 2020
All patients operated for oesophageal cancer in Sweden from 2013 to April 2018 were identified, and 246 patients were recruited to this population‐based nationwide Swedish study. The results show that longitudinal health‐related quality of life after minimally invasive oesophagectomy was similar to that of the open surgical approach.
F. Klevebro, J. H. Kauppila, S. Markar, A. Johar, P. Lagergren   +4 more
wiley   +1 more source

Gamma oscillations and application of 40‐Hz audiovisual stimulation to improve brain function

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Background Audiovisual stimulation, such as auditory stimulation, light stimulation, and audiovisual combined stimulation, as a non‐invasive stimulation, which can induce gamma oscillation, has received increased attention in recent years, and it has been preliminarily applied in the clinical rehabilitation of brain dysfunctions, such as ...
Xixi Chen, Xiaolong Shi, Yuwei Wu, Zhiqing Zhou, Songmei Chen, Yan Han, Chunlei Shan   +6 more
wiley   +1 more source

The protective effect of M40401, a superoxide dismutase mimetic, on post-ischemic brain damage in Mongolian gerbils [PDF]

, 2003
BACKGROUND: Overproduction of free radical species has been shown to occur in brain tissues after ischemia-reperfusion injury. However, most of free radical scavengers known to antagonize oxidative damage (e.g. superoxide dismutase, catalase), are unable
Granato, Teresa, Iannone, Michelangelo, Modesti, Andrea, Mollace, Vincenzo, Muscoli, Carolina, Nisticò, Robert, Palma, Ernesto, Rotiroti, Domenicantonio, Salvemini, Daniela   +8 more
core   +2 more sources

MicroRNA-424 Protects Against Focal Cerebral Ischemia and Reperfusion Injury in Mice by Suppressing Oxidative Stress

Stroke, 2015
Background and Purpose— We previously showed that the microRNA miR-424 protects against permanent cerebral ischemic injury in mice by suppressing microglia activation.
Ping Liu, Haiping Zhao, Rongliang Wang, Peng Wang, Z. Tao, Li Gao, Feng Yan, Xiangrong Liu, Shun Yu, X. Ji, Yumin Luo   +10 more
semanticscholar   +1 more source

Rapid Blood Clot Removal via Remote Delamination and Magnetization of Clot Debris

Advanced Science, EarlyView.
A programmable colloidal microswarm is developed to quickly detach blood clots and enable rapid recanalization, with the detached debris functioning as a magnetic “debris‐robot” that can be efficiently propelled and retrieved via catheter suction, which could significantly save time compared to the critical “Golden 6 hours” window for ischemic stroke ...
Qinglong Wang, Ben Wang, Kai Fung Chan, Xin Song, Qianqian Wang, Fengtong Ji, Lin Su, Bonaventure Yiu Ming Ip, Ho Ko, Philip Wai Yan Chiu, Thomas Wai Hong Leung, Li Zhang   +11 more
wiley   +1 more source

Simulation‐based team‐training in acute stroke: Is it safe to speed up?

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Background In acute ischemic stroke (AIS), rapid treatment with intravenous thrombolysis (IVT) is crucial for good clinical outcome. Weekly simulation‐based team‐training of the stroke treatment team was implemented, resulting in faster treatment times.
Liv Jorunn Høllesli, Soffien Chadli Ajmi, Martin W. Kurz, Thomas Bailey Tysland, Morten Hagir, Ingvild Dalen, Sigrun Anna Qvindesland, Hege Ersdal, Kathinka D. Kurz   +8 more
wiley   +1 more source

Inhibition of the cGAS–STING pathway: contributing to the treatment of cerebral ischemia-reperfusion injury

Neural Regeneration Research
The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart, liver, brain, and kidney, but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically reviewed.
Hang Yang, Yulei Xia, Yue Ma, Mingtong Gao, Shuai Hou, Shanshan Xu, Yanqiang Wang   +6 more
doaj   +1 more source

Cyclooxygenase inhibition in ischemic brain injury [PDF]

Current Pharmaceutical Design 2008; 14(14):1401-1418, 2008
Neuroinflammation is one of the key pathological events involved in the progression of brain damage caused by cerebral ischemia. Metabolism of arachidonic acid through cyclooxygenase (COX) enzymes is known to be actively involved in the neuroinflammatory events leading to neuronal death after ischemia.
arxiv