Results 81 to 90 of about 366,900 (304)

The Roles of High Mobility Group Box 1 in Cerebral Ischemic Injury

Frontiers in Cellular Neuroscience, 2020
High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that plays an important role in stabilizing nucleosomes and DNA repair. HMGB1 can be passively released from necrotic neurons or actively secreted by microglia, macrophages/monocytes, and ...
Xiaoyun Gou, Xiaoyun Gou, Junjie Ying, Junjie Ying, Yan Yue, Yan Yue, Xia Qiu, Xia Qiu, Peng Hu, Peng Hu, Yi Qu, Yi Qu, Jinhui Li, Jinhui Li, Dezhi Mu, Dezhi Mu   +15 more
doaj   +1 more source

A review of medicinal herbs with antioxidant properties in the treatment of cerebral ischemia and reperfusion [PDF]

, 2015
BACKGROUND AND OBJECTIVE: Stroke is the second most common cause of death and a major cause of disability in individuals aged over 65 years, worldwide.
Bigdeli, M.R., Lorigooini, Z., Rabiei, Z.   +2 more
core  

Small Vessel Disease in the Heart and Brain: Current Knowledge, Unmet Therapeutic Need and Future Directions [PDF]

, 2019
No abstract ...
Berry, C, Ford, TJ, Hainsworth, AH, Kaski, JC, Pereira, AC, Sidik, N, Touyz, RM   +6 more
core   +2 more sources

ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke

Advanced Science, EarlyView.
Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju, Tao Zhang, Jianchen Cui, Yulim Lee, Suho Lee, Ho Min Kim, Boohwi Hong, Jiho Park, Chul Hee Choi, Hyon‐Seung Yi, Jun Young Heo, Woosuk Chung   +11 more
wiley   +1 more source

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

Neural Regeneration Research
Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient’s condition; this phenomenon is known as cerebral ischemia-reperfusion injury.
Zi Ye, Runqing Liu, Hangxing Wang, Aizhen Zuo, Cen Jin, Nan Wang, Huiqi Sun, Luqian Feng, Hua Yang   +8 more
doaj   +1 more source

Data science of stroke imaging and enlightenment of the penumbra. [PDF]

, 2015
Imaging protocols of acute ischemic stroke continue to hold significant uncertainties regarding patient selection for reperfusion therapy with thrombolysis and mechanical thrombectomy.
Liebeskind, David S, Nour, May, Scalzo, Fabien   +2 more
core   +2 more sources

Lipocalin-2 Mediated Polarization of Neutrophil in Cerebral Ischemia-Reperfusion Injury [PDF]

, 2021
Zhiliang Guo, Guoli Xu, Xu Jiaping, Yaqian Huang, Chun‐Feng Liu, Yongjun Cao   +5 more
openalex   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

Salidroside ameliorates cerebral ischemic injury and regulates the glutamate metabolism pathway in astrocytes

Frontiers in Pharmacology
Background and AimSalidroside (SA) is the main active component of Rhodiola rosea L., with potential in treating cardiovascular and cerebrovascular diseases and cerebral ischemia.
Xiaoyu Zheng, Hongwei Zhang, Hongwei Zhang, Yehao Zhang, Zhao Ding, Zishan Huang, Zishan Huang, Haoran Li, Haoran Li, Mingjiang Yao, Wenting Song, Jianxun Liu   +11 more
doaj   +1 more source

Protective Effect of Aerobic Exercise and Adenosine on Changes in Inflammation Mediators after Transient Ischemia of Common Carotid Arteries in Male Wistar Rats

مجله دانشگاه علوم پزشکی گرگان, 2021
Background and Objective: Stroke and cerebral ischemia are the second leading causes of death in the world. Currently, there are limited therapeutic interventions for patients with ischemia / reperfusion.
Zahra Eslami, Zeinab Mohammadi, Shohreh Sharifian, Masoumeh Rezaei Ghomi, Seyedeh Vafa Mousavi, Mahboubeh Farhadi, Najmeh Sheikh Robati, Zeinab Faghfoori, Seyed Javad Mirghani   +8 more
doaj