Results 81 to 90 of about 372,366 (307)

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Effect of Saponin on Cerebral Edema Rate in An Animal Model of Stroke

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Oxidative stress and neuroinflammation are the main causes of cerebral ischemia. Saponin with steroid or triterpenoid compounds with a sugar part has strong antioxidant and anti-inflammatory properties.
Elmira Shiri, Mohammad Reza Bigdeli, Akram Eidi, Seyed Pejman Mortazavi   +3 more
doaj  

The Roles of High Mobility Group Box 1 in Cerebral Ischemic Injury

Frontiers in Cellular Neuroscience, 2020
High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that plays an important role in stabilizing nucleosomes and DNA repair. HMGB1 can be passively released from necrotic neurons or actively secreted by microglia, macrophages/monocytes, and ...
Xiaoyun Gou, Xiaoyun Gou, Junjie Ying, Junjie Ying, Yan Yue, Yan Yue, Xia Qiu, Xia Qiu, Peng Hu, Peng Hu, Yi Qu, Yi Qu, Jinhui Li, Jinhui Li, Dezhi Mu, Dezhi Mu   +15 more
doaj   +1 more source

Small Vessel Disease in the Heart and Brain: Current Knowledge, Unmet Therapeutic Need and Future Directions [PDF]

, 2019
No abstract ...
Berry, C, Ford, TJ, Hainsworth, AH, Kaski, JC, Pereira, AC, Sidik, N, Touyz, RM   +6 more
core   +2 more sources

Smart Catheters for Diagnosis, Monitoring, and Therapy

Advanced Healthcare Materials, EarlyView.
This study presents a comprehensive review of smart catheters, an emerging class of medical devices that integrate embedded sensors, robotics, and communication systems, offering increased functionality and complexity to enable real‐time health monitoring, diagnostics, and treatment. Abstract This review explores smart catheters as an emerging class of
Azra Yaprak Tarman, Samiha Ahmed, Majed Othman Althumayri, Megan Guy, Darlenne Chavez Lugo, Frances S. Ligler, George T. Ligler, Rahmi Oklu, Hiroshi Kawahira, Michael J. McShane, Jun Kameoka, Jonathan Bova, Hatice Ceylan Koydemir   +12 more
wiley   +1 more source

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

Neural Regeneration Research
Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient’s condition; this phenomenon is known as cerebral ischemia-reperfusion injury.
Zi Ye, Runqing Liu, Hangxing Wang, Aizhen Zuo, Cen Jin, Nan Wang, Huiqi Sun, Luqian Feng, Hua Yang   +8 more
doaj   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

Salidroside ameliorates cerebral ischemic injury and regulates the glutamate metabolism pathway in astrocytes

Frontiers in Pharmacology
Background and AimSalidroside (SA) is the main active component of Rhodiola rosea L., with potential in treating cardiovascular and cerebrovascular diseases and cerebral ischemia.
Xiaoyu Zheng, Hongwei Zhang, Hongwei Zhang, Yehao Zhang, Zhao Ding, Zishan Huang, Zishan Huang, Haoran Li, Haoran Li, Mingjiang Yao, Wenting Song, Jianxun Liu   +11 more
doaj   +1 more source

Protective Effect of Aerobic Exercise and Adenosine on Changes in Inflammation Mediators after Transient Ischemia of Common Carotid Arteries in Male Wistar Rats

مجله دانشگاه علوم پزشکی گرگان, 2021
Background and Objective: Stroke and cerebral ischemia are the second leading causes of death in the world. Currently, there are limited therapeutic interventions for patients with ischemia / reperfusion.
Zahra Eslami, Zeinab Mohammadi, Shohreh Sharifian, Masoumeh Rezaei Ghomi, Seyedeh Vafa Mousavi, Mahboubeh Farhadi, Najmeh Sheikh Robati, Zeinab Faghfoori, Seyed Javad Mirghani   +8 more
doaj  

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source