Results 111 to 120 of about 1,645,602 (269)

Spontaneous Hepatobiliary Disease in a Breeding Colony of Aotus spp.

Journal of Medical Primatology, Volume 55, Issue 5, October 2026.
ABSTRACT Background Owl monkeys are nonhuman primate species in the genus Aotus. The Michale E. Keeling Center for Comparative Medicine and Research maintains an Owl Monkey Breeding and Research Resource composed of four species of owl monkeys: Aotus nancymai, A. vociferans, A. azarae, and A. griseimembra.
M. E. Hensel, G. W. Wilkerson, L. Yan, C. L. Hodo, S. M. Kezar   +4 more
wiley   +1 more source

Cytokine Profiles in Malawian Children Presenting with Uncomplicated Malaria, Severe Malarial Anemia, and Cerebral Malaria

Clinical and Vaccine Immunology, 2017
Proinflammatory cytokines are involved in clearance of Plasmodium falciparum, and very high levels of these cytokines have been implicated in the pathogenesis of severe malaria. In order to determine how cytokines vary with disease severity and syndrome,
W. Mandala, C. Msefula, Esther N. Gondwe, M. Drayson, M. Molyneux, C. MacLennan   +5 more
semanticscholar   +1 more source

Uncomplicated Malaria in Infancy and Neurodevelopment at 1 and 6 Years: Evidence From the MiPPAD Birth Cohort Study of Benin

Tropical Medicine &International Health, Volume 31, Issue 10, Page 1395-1407, October 2026.
ABSTRACT In malaria‐endemic regions, repeated episodes of uncomplicated malaria during infancy are common; however, their associations with neurodevelopment remain unclear. We examined relationships between malaria frequency in infancy and neurodevelopmental outcomes in early and middle childhood, using data from the APEC birth cohort nested within the
Juthathip Khongpetch, Michael J. Boivin, Michel Cot, Jacqueline Milet, Roméo Zoumenou, Christophe Fermanian, Achille Massougbodji, Florence Bodeau‐Livinec   +7 more
wiley   +1 more source

Heritability of malaria in Africa [PDF]

, 2005
Background While many individual genes have been identified that confer protection against malaria, the overall impact of host genetics on malarial risk remains unknown.
Williams, Thomas N., Mackinnon, Margaret J., Marsh Kevin, Snow, RW, Marsh, K, Robert W Snow, Kevin Marsh, Snow, Robert W., Snow Robert W, Williams Thomas N, Snow, Robert, Mackinnon, Margaret, Tabitha W Mwangi, Mackinnon Margaret J, Mackinnon, MJ, Mwangi, TW, Thomas N Williams, Williams, TN, Mwangi, Tabitha W., Williams, Thomas, Margaret J Mackinnon, Marsh, Kevin, Mwangi Tabitha W   +22 more
core   +1 more source

Human cerebral malaria and Plasmodium falciparum genotypes in Malawi

Malaria Journal, 2012
Background Cerebral malaria, a severe form of Plasmodium falciparum infection, is an important cause of mortality in sub-Saharan African children.
Milner Danny A, Vareta Jimmy, Valim Clarissa, Montgomery Jacqui, Daniels Rachel F, Volkman Sarah K, Neafsey Daniel E, Park Daniel J, Schaffner Stephen F, Mahesh Nira C, Barnes Kayla G, Rosen David M, Lukens Amanda K, Van-Tyne Daria, Wiegand Roger C, Sabeti Pardis C, Seydel Karl B, Glover Simon J, Kamiza Steve, Molyneux Malcolm E, Taylor Terrie E, Wirth Dyann F   +21 more
doaj   +1 more source

Haemodynamic effects of selective venoconstriction with centhaquine in spontaneously breathing patients with mixed hypovolaemic‐vasodilatory shock

Experimental Physiology, Volume 111, Issue 10, Page 4421-4434, 1 October 2026.
Abstract Circulatory shock remains difficult to manage because fluid resuscitation and catecholamines may exacerbate vascular dysfunction and tissue hypoperfusion. This prospective physiological analysis, embedded within a multicentre phase IV study, examined whether selectively targeting the venous circulation with centhaquine improves circulatory ...
Athanasios Chalkias, Aman Khanna, Krish Vaidya, Dharmesh Shah, Anil Gulati   +4 more
wiley   +1 more source

Glucose metabolism mediates disease tolerance in cerebral malaria

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Feeding behavior changes drastically with infection and is a conserved behavioral response. However, the mechanistic aspects of how this behavior provides a survival advantage are poorly understood.
Andrew Wang, Sarah C. Huen, Harding H. Luan, Kelly K Baker, H. Rinder, C. Booth, R. Medzhitov   +6 more
semanticscholar   +1 more source

Endothelial transcriptomic analysis identifies biomarkers of severe and cerebral malaria

JCI Insight, 2023
Malaria can quickly progress from an uncomplicated infection into a life-threatening severe disease. However, the unspecificity of early symptoms often makes it difficult to identify patients at high risk of developing severe disease.
Cláudia Gomes, Rosauro Varo, Miquel Duran-Frigola, Antonio Sitoe, Rubão Bila, Sonia Machevo, Alfredo Mayor, Quique Bassat, Ana Rodriguez   +8 more
doaj   +1 more source

Design, Synthesis, and Evaluation of New 1,4‐Naphthoquinone‐1,2,3‐triazoles as Antimalarial Agents

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Compound 9g, a 1,4‐naphthoquinone‐1,2,3‐triazole derivative, exhibited potent activity against P. falciparum 3D7 and in silico analysis revealed strong interactions with 1J3 and 1LDG targets, while MD simulations confirmed the stability of the ligand‐3FGO complex.
Lina Rezainia, Mohammad Hosein Sayahi, Eisa Kaveh Vernousfaderani, Seyedeh Sara Mirfazli, Mohammad Hossein Morshedsolouk, Navid Dastyafteh, Mehdi Nateghpour, Leila Farivar, Mina Saeedi, Haleh Hanifian, Mahdi Mohebali, Seyedeh Mana Shafiee, Gholamreza Hassanpour, Mohammad Mahdavi   +13 more
wiley   +1 more source

Cerebral malaria in children

The Lancet, 1990
Cerebral malaria is a rapidly progressive encephalopathy with up to 50% mortality. A cardinal feature is the massing of red cells containing mature Plasmodium falciparum within the cerebral capillaries. Adhesion of these parasitised red cells to endothelium, an event which may initiate cerebral malaria, is being studied at the molecular level. However,
Phillips, R, Solomon, T
openaire   +3 more sources