Results 111 to 120 of about 28,910 (233)

A shared inflammatory signature across severe malaria syndromes manifested by transcriptomic, proteomic and metabolomic analyses

Nature Communications
Factors governing the clinical trajectory of Plasmodium falciparum infection remain an important area of investigation. Here we present transcriptomic, proteomic and metabolomic analyses comparing clinical subtypes of severe Plasmodium falciparum malaria
Rafal S. Sobota, Emily M. Stucke, Drissa Coulibaly, Jonathan G. Lawton, Bryan E. Cummings, Savy Sebastian, Antoine Dara, James B. Munro, Amed Ouattara, Abdoulaye K. Kone, Bourama Kane, Karim Traoré, Bouréima Guindo, Bourama M. Tangara, Amadou Niangaly, Noah T. Ventimiglia, Modibo Daou, Issa Diarra, Youssouf Tolo, Mody Sissoko, Fayçal Maiga, Aichatou Diawara, Amidou Traore, Ali Thera, Matthew B. Laurens, Kirsten E. Lyke, Bourema Kouriba, Ogobara K. Doumbo, Christopher V. Plowe, David R. Goodlett, Joana C. Silva, Mahamadou A. Thera, Mark A. Travassos   +32 more
doaj   +1 more source

Pathogenesis of Cerebral Malaria: New Diagnostic Tools, Biomarkers and Therapeutic Approaches

Frontiers in Cellular and Infection Microbiology, 2015
Cerebral malaria is a severe neuropathological complication of Plasmodium falciparum infection. It results in high mortality and post-recovery neuro-cognitive disorders in children, even after appropriate treatment with effective anti-parasitic drugs ...
Praveen Kishore Sahu, Sanghamitra eSatpathi, Prativa eBehera, Saroj Kanti Mishra, Sanjib eMohanty, Samuel C Wassmer, Samuel C Wassmer   +6 more
doaj   +1 more source

Defining childhood severe falciparum malaria for intervention studies. [PDF]

, 2007
Background Clinical trials of interventions designed to prevent severe falciparum malaria in children require a clear endpoint. The internationally accepted definition of severe malaria is sensitive, and appropriate for clinical purposes.
Isaiah Mwangi, Bejon, K, Maitland, Kathryn, Bejon, P, Tabitha Mwangi, J Anthony G Scott, Kevin Marsh, Charles R J C Newton, G. Scott, Berkley, James A, Thomas Williams, Peshu, N, Kathryn Maitland, Brett S Lowe, Berkley, JA, Edna Ogada, Mwangi, I, Norbert Peshu, Brett S. Lowe, Maitland, K, English, M, Lowe, BS, James A Berkley, Newton, Charles RJC, Newton, CR, Peshu, Norbert, Lowe, Brett S, Philip Bejon, Bejon, Philip, Marsh, K, Mwangi, T, Mwangi, Tabitha, Scott, JA, Charles R. J. C. Newton, Williams, T, Scott, J Anthony G, Mike English, Ogada, Edna, J. Anthony, Williams, Thomas, English, Mike, Ogada, E, Mwangi, Isaiah, Marsh, Kevin, James A. Berkley   +44 more
core   +1 more source

Malaria and susceptibility to other infections [PDF]

Malaria is widely perceived as immunosuppressive. Despite extensive phenomenological description, the underlying mechanisms remain poorly described. The aim of this thesis was to identify possible mechanisms by which malaria modifies host defence, and
Cunnington, Aubrey Justin
core   +1 more source

Health workers' use of malaria rapid diagnostic tests (RDTs) to guide clinical decision making in rural dispensaries, Tanzania. [PDF]

, 2010
Rapid diagnostic tests (RDTs) were developed as an alternative to microscopy for malaria diagnosis. The RDTs detect malaria parasite antigen(s) in whole blood with high sensitivity and specificity.
M. Irene Masanja, McMorrow, Meredith, Kachur, S Patrick, Peter D. McElroy, S. Patrick Kachur, McElroy, Peter D, Meredith McMorrow, Masanja, M Irene, Kahigwa, Elizeus, Elizeus Kahigwa   +9 more
core   +1 more source

Epidemiology of malaria in the forest-savanna transitional zone of Ghana. [PDF]

, 2009
BACKGROUND: Information on the epidemiology of malaria is essential for designing and interpreting results of clinical trials of drugs, vaccines and other interventions.
Adjuik, Martin, Daniel Chandramohan, Gyapong, John, Asante, Kwaku Poku, Adams, Mohammed, Owusu-Agyei, Seth, David Dosoo, Sam Newton, Adjei, George, Newton Sam, John Gyapong, Kwaku Asante, George Adjei, Dery, Dominic, Elizabeth Awini, Martin Adjuik, Mohammed Adams, Newton, Sam, Greenwood, Brian, Brian Greenwood, Adjuik Martin, Chandramohan Daniel, Awini, Elizabeth, Dosoo, David, Greenwood Brian, Seth Owusu-Agyei, Owusu-Agyei Seth, Asante Kwaku, Agyeman-Budu, Akua, Dosoo David, Chandramohan, Daniel, Adjei George, Dominic Dery, Dery Dominic, Akua Agyeman-Budu, Agyeman-Budu Akua, Adams Mohammed, Awini Elizabeth, Gyapong John   +38 more
core   +1 more source

Long-term impact of malaria chemoprophylaxis on cognitive abilities and educational attainment: follow-up of a controlled trial. [PDF]

, 2006
OBJECTIVES: We investigated the long-term impact of early childhood malaria prophylaxis on cognitive and educational outcomes. DESIGN: This was a household-based cluster-controlled intervention trial.
Cheung, Yin Bun, Bundy, Donald AP, Milligan Paul, Greenwood, Brian M, Pinder Margaret, Grigorenko Elena L, Sternberg Robert J, Jukes Matthew C. H, Grigorenko, Elena L, Milligan, Paul, Walraven, Gijs, Smith Helen Baños, Sternberg, Robert J, Bundy Donald A. P, Bariau Elisa Meier, Jukes, Matthew CH, Bariau, Elisa Meier, Walraven Gijs, Cheung Yin Bun, Drake, Lesley J, Smith, Helen Baños, Pinder, Margaret, Greenwood Brian M, Drake Lesley J   +23 more
core   +1 more source

Cerebral malaria: insight into pathogenesis, complications and molecular biomarkers

, 2017
Farah Hafiz Yusuf,1 Muhammad Yusuf Hafiz,1 Maria Shoaib,1 Syed Ahsanuddin Ahmed2 1Department of Medicine, Dow Medical College, Dow University of Health Sciences, 2Department of Medicine, Sindh Medical College, Jinnah Sindh Medical University, Karachi ...
Hafiz MY, Yusuf FH, Shoaib M, Ahmed SA
core  

Intermittent preventive treatment for malaria in infants: a decision-support tool for sub-Saharan Africa. [PDF]

, 2010
OBJECTIVE: To develop a decision-support tool to help policy-makers in sub-Saharan Africa assess whether intermittent preventive treatment in infants (IPTi) would be effective for local malaria control.
Arantxa Roca-Feltrer, Amanda Ross, Schellenberg, David, Schellenberg, D., Ross, A., Roca-Feltrer A.,, Ross, Amanda, Smith, L., Schellenberg, J. A., David Schellenberg, Thomas Smith, Joanna Armstrong Schellenberg, Carneiro, Ilona, Smith, T., Carneiro, I., Roca-Feltrer, Arantxa, Schellenberg, Joanna Armstrong, Lucy Smith, Smith, Thomas, Greenwood, Brian, Brian Greenwood, Greenwood, B., Smith, Lucy, Ilona Carneiro   +23 more
core   +1 more source

Cerebral Malaria. A review

, 2003
RESUMEN: La malaria cerebral (MC) es la complicación más frecuente de la malaria por P. falciparum; aproximadamente el 90% de las personas que la han padecido se recuperan completamente sin secuelas neurológicas.
Zapata Zapata, Carlos Hugo, Blair Trujillo, Silvia   +1 more
core