Results 141 to 150 of about 460,913 (180)

Cerebral Microdialysis in Neurocritical Care

Current Neurology and Neuroscience Reports, 2018
A major goal in neurocritical care is to monitor for and prevent secondary brain injuries. However, injuries occurring at the cellular and molecular levels evade detection by conventional hemodynamic monitoring and the neurological exam. Cerebral microdialysis (CMD) is an invasive means of providing nearly continuous measurements of cerebral metabolism
Ting, Zhou, Atul, Kalanuria
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Cerebral microdialysis in the current clinical setting

Medicina Intensiva (English Edition), 2012
Cerebral microdialysis, introduced in experimental studies 40 years ago, has been used clinically since 1992 for the neurochemical monitoring of patients in intensive care. The principles underlying this technique are closely related to brain metabolism. The study of the metabolites detected at brain interstitial tissue level, through the semipermeable
J, Revuelto-Rey, J J, Egea-Guerrero, M A, Muñoz-Sánchez, F, Murillo-Cabezas   +3 more
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On-line Monitoring of Cerebral pH by Microdialysis

Neurosurgery, 1993
An on-line pH meter that can be mounted in microdialysis systems is described. The pH monitoring system was tested in rat cortex before and after middle cerebral artery occlusion (focal ischemia model). After probe implantation, pH values in the dialysate quickly reached a stable level that depended on perfusion medium (6.72, Ringer; 6.47, 0.9% saline)
Landolt H, Langemann H, Gratzl O
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Clinical cerebral microdialysis: a methodological study

Journal of Neurosurgery, 2000
Object. Clinical microdialysis enables monitoring of the cerebral extracellular chemistry of neurosurgical patients. Introduction of the technique into different hospitals' neurosurgical units has resulted in variations in the method of application.
P J, Hutchinson, M T, O'Connell, P G, Al-Rawi, L B, Maskell, R, Kett-White, A K, Gupta, H K, Richards, D B, Hutchinson, P J, Kirkpatrick, J D, Pickard   +9 more
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Exploring Cerebral Metabolism by Microdialysis

1999
Microdialysis (MD) has been widely used for sampling of chemical substances from the interstitial fluid of the brain in experimental research. In the late 1980s, MD was introduced for studies on the human brain and neurochemical sampling was carried out in conjunction with neurosurgical procedures [1, 2, 3]. In 1992 we reported the use of intracerebral
L. Persson, L. Hillered
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[Cerebral microdialysis in stroke].

Der Nervenarzt, 2004
Cerebral microdialysis is an invasive technique for neurochemical monitoring that has been established for neuro-critical disorders such as subarachnoid hemorrhage and severe brain injury. We present data on cerebral microdialysis in stroke patients which were obtained in an ongoing study supported by the German Ministry for Education and Research.
Berger, C., Dohmen, C., Maurer, M., Graf, R., Schwab, S.   +4 more
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Cerebral Microdialysis

Abstract Cerebral microdialysis (CMD) is a focal monitoring technique used to assess brain tissue chemistry. It allows the measurement of energy-related metabolites such as glucose, lactate, and pyruvate, as well as markers of tissue damage, such as glycerol, neurotransmitters, and cytokines.
Sara Venturini, Keri L.H. Carpenter, Peter J. Hutchinson, Adel Helmy   +3 more
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Cerebral microdialysis in glioma studies, from theory to application

Journal of Pharmaceutical and Biomedical Analysis, 2014
Despite recent advances in the treatment of solid tumors, there are few effective treatments for malignant gliomas due to the infiltrative nature, and the protective shield of blood-brain barrier or blood-tumor barriers that restrict the passage of chemotherapy drugs into the brain.
Lin, Liu, Xiangyi, Zhang, Yan, Lou, Yuefeng, Rao, Xingguo, Zhang   +4 more
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A Concept for the Introduction of Cerebral Microdialysis in Neurointensive Care

1996
Before microdialysis (MD) can be introduced into the clinic as an improved method of cerebral monitoring, certain ethical, methodological and clinical factors must be considered. Access to the brain for probe insertion is offered by craniotomy or by routine intracranial pressure (ICP) monitoring and the additional lesion is minimal.
Landolt H, Langemann H, Alessandri B
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In vivo monitoring of cerebral agmatine by microdialysis and capillary electrophoresis

Journal of Chromatography B, 2012
Agmatine is a putative neurotransmitter in the brain. Current analytical techniques do not allow the detection of agmatine in extracellular fluid, making it difficult to study its physiological role. However, a new method for in vivo monitoring agmatine in the brain was developed. Capillary zone electrophoresis and laser induced fluorescence detection (
Luis, Betancourt, Pedro, Rada, Daniel, Paredes, Luis, Hernández   +3 more
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