Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals. [PDF]
, 2015 BackgroundClinically significant dysregulation of the insulin-like growth factor (IGF) family proteins occurs in HIV-infected individuals, but the details including whether the deficiencies in IGFs contribute to CNS dysfunction are unknown.MethodsWe ...
Choi, Namjong +4 more
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Review of "Proteins of the Cerebrospinal Fluid" (2nd Edition) by Edward J. Thompson [PDF]
Cerebrospinal Fluid Research, 2007 This book on cerebrospinal fluid (CSF) proteins is primarily focused on immunoglobulins. The book was written as an extension of a meeting on multiple sclerosis to provide a more extensive consideration of the CSF.
Connor James R
doaj +2 more sources
SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity
Fluids and Barriers of the CNS, 2021 Cerebrospinal fluid is a clear fluid that occupies the ventricular and subarachnoid spaces within and around the brain and spinal cord. Cerebrospinal fluid is a dynamic signaling milieu that transports nutrients, waste materials and neuroactive ...
Vania Sepúlveda +4 more
doaj +1 more source
Laboratory Investigation of Cerebrospinal Fluid Proteins [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1990 Analysis of CSF proteins is useful in the diagnosis and management of neurological diseases in the following situations:In inflammatory conditions when there is breakdown of blood-CSF barrier integrity. Meningitis is a medical emergency, with CSF total protein measurement being only a screening test. In the detection of immune responses within the CNS.
E J, Thompson, G, Keir
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Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid. [PDF]
, 2016 BackgroundClinical diagnosis of parkinsonian syndromes like Parkinson's disease (PD), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is hampered by overlapping symptomatology and lack of diagnostic biomarkers, and definitive ...
Boman, Andrea +8 more
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Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients. [PDF]
, 2015 Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), the cause of Huntington's disease (HD), is at ...
Andreas Weiss +16 more
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Sex-Related Differences in Cerebrospinal Fluid Plasma-Derived Proteins of Neurological Patients
Diagnostics, 2021 Background and aims: Cerebrospinal fluid (CSF) protein content presents a sexual dimorphism in humans. We investigated sex-related differences in CSF IgG levels and in the quantification of intrathecal IgG synthesis (IIS). Methods: CSF, serum albumin and
Massimiliano Castellazzi +10 more
doaj +1 more source
Cerebrospinal Fluid Protein Changes in Preeclampsia [PDF]
Hypertension, 2018 The molecular mechanisms underlying seizure susceptibility in preeclampsia are unknown. We hypothesized that altered expression of distinct proteins in the cerebrospinal fluid (CSF) may reflect pathophysiological changes in the central nervous system that contribute to the neurological manifestations of severe preeclampsia. We obtained CSF
Erin, Ciampa +7 more
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How shall we use the proteomics toolbox for biomarker discovery? [PDF]
, 2007 Biomarker discovery for clinical purposes is one of the major areas in which proteomics is used. However, despite considerable effort, the successes have been relatively scarce.
Hochstrasser, Denis +2 more
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Addressing the needs of traumatic brain injury with clinical proteomics. [PDF]
, 2014 BackgroundNeurotrauma or injuries to the central nervous system (CNS) are a serious public health problem worldwide. Approximately 75% of all traumatic brain injuries (TBIs) are concussions or other mild TBI (mTBI) forms.
Loo, Joseph A +3 more
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