Addressing the needs of traumatic brain injury with clinical proteomics. [PDF]
, 2014 BackgroundNeurotrauma or injuries to the central nervous system (CNS) are a serious public health problem worldwide. Approximately 75% of all traumatic brain injuries (TBIs) are concussions or other mild TBI (mTBI) forms.
Loo, Joseph A +3 more
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Alzheimer’s Research & Therapy, 2020 Background Cerebrospinal fluid biomarker profiles characterized by decreased amyloid-beta peptide levels and increased total and phosphorylated tau levels at threonine 181 (pT181) are currently used to discriminate between Alzheimer’s disease and other ...
Nicolas R. Barthélemy +7 more
doaj +1 more source
Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease. [PDF]
PLoS ONE, 2016 Alzheimer's disease is a neurodegenerative disorder accounting for more than 50% of cases of dementia. Diagnosis of Alzheimer's disease relies on cognitive tests and analysis of amyloid beta, protein tau, and hyperphosphorylated tau in cerebrospinal ...
Payam Emami Khoonsari +10 more
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CSF protein biomarkers predicting longitudinal reduction of CSF β-amyloid42 in cognitively healthy elders. [PDF]
, 2013 β-amyloid (Aβ) plaque accumulation is a hallmark of Alzheimer's disease (AD). It is believed to start many years prior to symptoms and is reflected by reduced cerebrospinal fluid (CSF) levels of the peptide Aβ1-42 (Aβ42).
Alzheimer's Disease Neuroimaging Initiative +8 more
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Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease [PDF]
, 2007 So far, only the detection of 14-3-3 proteins in cerebrospinal fluid (CSF) has been accepted as diagnostic criterion for Creutzfeldt-Jakob disease (CJD). However, this assay cannot be used for screening because of the high rate of false-positive results,
Brit Mollenhauer +19 more
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Increased age and male sex are independently associated with higher frequency of blood–cerebrospinal fluid barrier dysfunction using the albumin quotient [PDF]
, 2020 Background: The cerebrospinal fluid (CSF)/serum quotient of albumin (QAlb) is the most used biomarker for the evaluation of blood–cerebrospinal fluid barrier (B-CSF-B) permeability.
Alessi, Francesca +12 more
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Cisternal versus lumbar cerebrospinal fluid lactate concentration in healthy dogs
Veterinární Medicína, 2020 The analysis of cerebrospinal fluid biomarkers provides a wide range of information about the neurological health of a patient. Lactate is a metabolic precursor necessary for brain gluconeogenesis.
Alba Galan +6 more
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Murine MPDZ-linked hydrocephalus is caused by hyperpermeability of the choroid plexus. [PDF]
, 2019 Though congenital hydrocephalus is heritable, it has been linked only to eight genes, one of which is MPDZ Humans and mice that carry a truncated version of MPDZ incur severe hydrocephalus resulting in acute morbidity and lethality.
Byrne, Matthew D. +17 more
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What Can N-glycomics and N-glycoproteomics of Cerebrospinal Fluid Tell Us about Alzheimer Disease?
Biomolecules, 2021 Proteomics—large-scale studies of proteins—has over the last decade gained an enormous interest for studies aimed at revealing proteins and pathways involved in disease.
Stefan Gaunitz +2 more
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Fast glycorrhachia and cerebrospinal fluid protein as predictors of sensory block in anesthesia with subarachnoid Ropivacaine [PDF]
, 2016 BACKGROUND: Identify if glycorrhachia and cerebrospinal fluid protein could influence the time of sensory block to T10, the duration and the metameric block's level, after a standard dose of Ropivacaine. METHODS: 80 patients, ASA I - III undergoing to
COLLINI, Saul +5 more
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