Results 31 to 40 of about 244,039 (307)
Laboratory Investigation of Cerebrospinal Fluid Proteins [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1990 Analysis of CSF proteins is useful in the diagnosis and management of neurological diseases in the following situations: In inflammatory conditions when there is breakdown of blood-CSF barrier integrity. Meningitis is a medical emergency, with CSF total protein measurement being only a screening test.
G Keir, E J Thompson
openaire +3 more sources
PLoS ONE, 2018 Cerebrospinal fluid is investigated in biomarker studies for various neurological disorders of the central nervous system due to its proximity to the brain. Currently, only a limited number of biomarkers have been validated in independent studies.
Lukas M Schilde +10 more
doaj +1 more source
How shall we use the proteomics toolbox for biomarker discovery? [PDF]
, 2007 Biomarker discovery for clinical purposes is one of the major areas in which proteomics is used. However, despite considerable effort, the successes have been relatively scarce.
Hochstrasser, Denis +2 more
core +5 more sources
Total and phosphorylated tau proteins: Evaluation as core biomarker candidates in frontotemporal dementia [PDF]
, 2004 An ever increasing number of patients with neurodegenerative disorders calls for the evaluation of potential diagnostic markers that allow an early diagnosis and an early initiation of specific therapy. Clinical diagnosis of Alzheimer's disease (AD), the
Hampel, H., Teipel, S. J.
core +1 more source
Characterize the non-Gaussian diffusion property of cerebrospinal fluid using Diffusion Kurtosis Imaging and explore its diagnostic efficacy for Alzheimer's disease [PDF]
arXiv, 2023 Differentiating Alzheimer's disease (AD) patients from healthy controls (HCs) remains a challenge. The changes of protein level in cerebrospinal fluid (CSF) of AD patients have been reported in the literature. Macromolecules will hinder the movement of water in CSF and lead to non-Gaussian diffusion.
arxiv
Disease progression model anchored around clinical diagnosis in longitudinal cohorts: example of Alzheimer's disease and related dementia [PDF]
, 2023 Background. Alzheimer's disease and related dementia (ADRD) are characterized by multiple and progressive anatomo clinical changes. Yet, modeling changes over disease course from cohort data is challenging as the usual timescales are inappropriate and time-to-clinical diagnosis is available on small subsamples of participants with short follow-up ...
arxiv +1 more source
Therapeutic Advances in Neurological Disorders, 2016 Introduction: Cerebrospinal fluid analysis may provide insight into the interplay between chronic inflammation and response to treatment. Objectives: To demonstrate the impact of one intrathecal triamcinolone injection on the redox potential and on ...
Thomas Müller +5 more
doaj +1 more source
Neuroimmunological findings of Angiostrongylus cantonensis meningitis in ecuadorian patients
Arquivos de Neuro-Psiquiatria, 2011 Meningitis caused by Angiostrongylus cantonensis has recently been reported in patients resulting from the first outbreaks in subtropical regions of Ecuador. METHOD: Eight young adult patients from the two outbreaks were studied.
Alberto J. Dorta-Contreras +6 more
doaj +1 more source
Annals of Medicine, 2023 Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and fibromyalgia have overlapping neurologic symptoms particularly disabling fatigue.
Steven E. Schutzer +9 more
doaj +1 more source
The genetic regulation of protein expression in cerebrospinal fluid
EMBO Molecular Medicine, 2022 Studies of the genetic regulation of cerebrospinal fluid (CSF) proteins may reveal pathways for treatment of neurological diseases. 398 proteins in CSF were measured in 1,591 participants from the BioFINDER study. Protein quantitative trait loci (pQTL) were identified as associations between genetic variants and proteins, with 176 pQTLs for 145 CSF ...
Oskar Hansson +13 more
openaire +4 more sources