Ceruloplasmin in Wilson's Disease* [PDF]
Journal of Clinical Investigation, 1967 Ceruloplasmin was highly purified from one patient with Wilson's disease and partially purified from a second unrelated patient. The highly purified ceruloplasmin was indistinguishable from normal ceruloplasmin by electrophoresis, tryptic peptide map, oxidase activity, and copper, amino acid, and sugar composition.
Neil A. Holtzman +3 more
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Evaluation of salivary ceruloplasmin for the diagnosis of Wilson’s disease [PDF]
Scientific ReportsThe serum ceruloplasmin assay is the most commonly used test for diagnosing Wilson’s disease (WD). Despite the utility of non-invasive tests for diagnosing WD, no such tests have been developed.
Nian Zhang +10 more
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Association of serum trace elements with non-invasive fibrosis scores in metabolic dysfunction-associated steatotic liver disease [PDF]
Scientific ReportsLiver biopsy is not a routine screening tool for detecting fibrosis progression in metabolic dysfunction-associated steatotic liver disease (MASLD). Noninvasive methods based on serum biomarkers are used instead.
Erfan Banisefid +5 more
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STUDIES ON CERULOPLASMIN METABOLISM
Nihon Naika Gakkai Zasshi, 1969 第1編*記載のごとくceruloplasmin合成の場は主として肝であると推定されるが, ceruloplasminは血清蛋白であり,肝における合成に加え,血清への放出の機構も問題で,またWilson病についても肝における銅とceruloplasminの関連を重視したものが多く, ceruloplasmin代謝における肝の役割は大である.肝での銅の動態追究によつて,複雑な肝の役割の一端に検討を加えるべく,肝スライスでの単純化された諸条件下のin vitroでの64CuCl2を用いての実験を行ない, ceruloplasminの肝での合成と銅の肝への取り込みにはactive transportの機構が推定され,一部は蛋白合成と関連したものと思われ,さらに肝内銅の存在様式が ...
Yozo FUJII
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Impact of Parenteral Copper and Zinc Administration on Reproduction, Inflammation, and Antioxidant Responses of Bos indicus Beef Heifers [PDF]
AnimalsTwo experiments evaluated the effects of copper (Cu) and zinc (Zn) injection on body weight (BW), body condition score (BCS), pregnancy rate, ovarian traits, and antioxidant and inflammatory responses of beef heifers. In Exp.
Luana Gomes da Silva +8 more
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Alteration of ceruloplasmin in patients with malaria: a systematic review and meta-analysis of observational studies [PDF]
Malaria JournalBackground The evidences of oxidative stress-related Plasmodium infection may alter the ceruloplasmin levels were inconsistent. This systematic review and meta-analysis aimed to collate and synthesize literatures on malaria and ceruloplasmin ...
Kwuntida Uthaisar Kotepui +4 more
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TDMQ20 as A Drug Candidate for Wilson’s Disease: Comparison with D-Penicillamine, Trientine, and Tetrathiomolybdate In Vitro and In Mice [PDF]
PharmaceuticsBackground/Objectives: The lifelong treatment of Wilson’s disease (WD) currently relies on copper chelators with relatively poor metal specificity, which frequently exhibit serious adverse effects.
Yingshan Zhu +8 more
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Exploring the interplay of prolactin and bromocriptine on serum markers in granulomatous lobular mastitis [PDF]
Frontiers in ImmunologyObjectiveIn this study, we retrospectively analyzed the relationship between PRL level and serum inflammatory and immune markers in patients with granulomatous lobular mastitis (GLM) and analyzed the effect of bromocriptine treatment on serum ...
Binheng Liu +9 more
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OBSERVATIONS ON CERULOPLASMIN IN WILSON'S DISEASE*† [PDF]
Journal of Clinical Investigation, 1959 Andrew Sass-Kortsāk +3 more
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Assessing whether serum ceruloplasmin promotes non-alcoholic steatohepatitis via regulating iron metabolism [PDF]
Journal of Medical Biochemistry, 2023 Background: Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD). The diagnostic gold standard for detecting NASH still relies upon an invasive pathological biopsy.
Xia Ziqiang +6 more
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