Results 71 to 80 of about 966,128 (305)

Distribution of HPV types associated with cervical cancers in Scotland and implications for the impact of HPV vaccines [PDF]

, 2010
This study evaluated human papillomavirus (HPV) type prevalence in 370 Scottish invasive cervical cancers (ICCs) using HPV genotyping and HPV mRNA ...
Millan, D, Cubie, Heather, Cuschieri, Kate, D H Brewster, Brewster, D H, C Graham, K Cuschieri, S Nicoll, H A Cubie, Murray, G, Graham, C, A R W Williams, Nicoll, S, D Millan, Hardie, A, J Imrie, Imrie, J, A Hardie, Williams, A R W, G Murray   +19 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Differentiating C8–T1 Radiculopathy from Ulnar Neuropathy: A Survey of 24 Spine Surgeons

Global Spine Journal, 2014
Study Design Questionnaire. Objective To evaluate the ability of spine surgeons to distinguish C8–T1 radiculopathies from ulnar neuropathy. Methods Twenty-four self-rated “experienced” cervical spine surgeons completed a questionnaire with the following ...
Geoffrey E. Stoker, Han Jo Kim, K. Daniel Riew MD   +2 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Opportunistic screening protocols for cervical carcinoma among different female populations in Chongqing

Di-san junyi daxue xuebao, 2019
Objective To evaluate the 5 protocols of opportunistic screening for cervical carcinoma among different female populations, in order to explore optional protocol for the women with different clinical characteristics.
YAN Li, YANG Jun, ZHOU Deping, ZHOU Xiaojun   +3 more
doaj   +1 more source

Evaluation report: Limerick awareness campaign, 6th-18th October 2003 / Fiona Tracey

, 2003
Irish Cervical Screening Programme ...
Irish Cervical Screening Programme (ICSP)
core  

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland [PDF]

, 2014
In Scotland, a national HPV immunisation programme began in 2008 for 12-13 year olds, with a catch-up campaign from 2008-2011 for those under the age of 18.
Kavanagh, K, Cruickshank, M, Cubie, H., C Robertson, Pollock, Kevin G.J., J Love, Pollock, K G J, Potts, A., Love, J., K Kavanagh, Cruickshank, M., Nicoll, Sheila, Donaghy, Martin, Palmer, Tim J, K Cuschieri, Robertson, C, Palmer, T J, M Donaghy, Cuschieri, K., Robertson, C., H, Cubie,, Potts, Alison, H Cubie, M Cruickshank, Nicoll, S., Donaghy, M, Pollock, K. G. J., Potts, A, Love, John, Cuschieri, Kate, Kavanagh, K., Donaghy, M., S Nicoll, Cuschieri, K, Cubie, H, Nicoll, S, Cruickshank, Maggie, T J Palmer, Love, J, Kavanagh, Kimberley, K G J Pollock, Robertson, Chris, Palmer, T. J., A Potts   +43 more
core   +1 more source