Results 51 to 60 of about 415,648 (260)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Assessing high-risk human papillomavirus-based cervical precancer screening recommendations and implications among women aged 60/65 years and older in Ghana

Scientific Reports
We aimed to assess the prevalence of high-risk HPV (hr-HPV) infection, cervical lesions observed through visual inspection, and abnormal cytology among women aged ≥ 60 years screened by the Cervical Cancer Prevention and Training Centre, Ghana.
Kofi Effah, Ethel Tekpor, Yaw Ohene-Bredu, Sadat Ibrahim, Stephen Tetteh Engmann, Stephen Danyo, Seyram Kemawor, Annita Edinam Dugbazah, Famous Afudego, Yohane Teye Kitcher, Gifty Belinda Klutsey, Bernard Hayford Atuguba, Nana Owusu Mensah Essel   +12 more
doaj   +1 more source

Posterior cervical foraminotomy for cervical radiculopathy: should cervical alignment be considered?

Journal of Spine Surgery, 2019
Concerning of progression of deformity, it is reluctant to utilize a posterior approach if preoperative sagittal alignment is kyphotic or straight. The purpose of this study was to determine interval changes in cervical segmental angles after posterior cervical foraminotomy (PCF) and analyzing factors affecting cervical sagittal re-alignment in the ...
Seok Won, Chung, Hyun Jun, Kim, Sang Ho, Lee, Shin Young, Lee, Min Soo, Kang, Yong Hwan, Shin, Chan Hong, Park   +6 more
openaire   +2 more sources

Cervical screening in Australia 2011-2012 [PDF]

, 2014
This report presents the latest national statistics monitoring the National Cervical Screening Program, which aims to reduce incidence, morbidity and mortality from cervical cancer.

core  

HPV types and cofactors causing cervical cancer in Peru. [PDF]

, 2001
We conducted a hospital-based case-control study in Peru of 198 women with histologically confirmed cervical cancer (173 squamous cell carcinomas and 25 cases of adenocarcinoma/adenosquamous carcinoma) and 196 control women.
Muñoz, N, J Walboomers, I Guerrero, E Caceres, Santos, C, Galdos, O, Castillo, M, Walboomers, J, S Klug, Caceres, E, C Velarde, M Almonte, Klug, S, O Galdos, Alvarez, M, N Muñoz, Meijer, C, C Santos, M Alvarez, Guerrero, I, C Meijer, Almonte, M, M Castillo, Velarde, C   +23 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Robotic-Assisted Transperitoneal Aortic Lymphadenectomy as Part of Staging Procedure for Gynaecological Malignancies: Single Institution Experience

Obstetrics and Gynecology International, 2013
Introduction. This study was designed to confirm the feasibility and safety of robotic-assisted transperitoneal aortic lymphadenectomy as part of staging procedure for gynecologic malignancies. Methods.
V. Zanagnolo, D. Rollo, T. Tomaselli, P. G. Rosenberg, L. Bocciolone, F. Landoni, G. Aletti, M. Peiretti, F. Sanguineti, A. Maggioni   +9 more
doaj   +1 more source

Inequalities in the incidence of cervical cancer in South East England 2001-2005: an investigation of population risk factors. [PDF]

, 2009
BACKGROUND: The incidence of cervical cancer varies dramatically, both globally and within individual countries. The age-standardised incidence of cervical cancer was compared across primary care trusts (PCTs) in South East England, taking into account ...
Jack, Ruth H, Jack Ruth H, Currin, Laura G, Elizabeth A Davies, Jack, Ruth H., Davies, Elizabeth A.; id_orcid, Henrik Møller, Mak, Vivian, Karen M Linklater, Møller Henrik, Møller, Henrik, Vivian Mak, Linklater, Karen M., Currin, Laura G., Mak Vivian, Moller, Henrik; id_orcid, Linklater, Karen M, Linklater Karen M, Ruth H Jack, Davies Elizabeth A, Laura G Currin, Davies, Elizabeth A, Currin Laura G   +22 more
core   +2 more sources

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Utilization and outcome estimates of cervical precancer screening and associated factors among female health workers in Ghana: implications for primary screening programs

BMC Health Services Research
Background Toward attaining the WHO’s 90-70-90 targets for cervical cancer elimination, female health workers (FHWs) play a crucial role in educating women about the importance of regular cervical screening and HPV vaccination.
Kofi Effah, Ethel Tekpor, Comfort Mawusi Wormenor, Gifty Belinda Klutsey, Edna Sesenu, Eyram Yaa Tsinigo, Seyram Kemawor, Stephen Danyo, Bernard Hayford Atuguba, George Griffith Legbedze, Nana Owusu Mensah Essel, Emmanuel Timmy Donkoh   +11 more
doaj   +1 more source