Results 211 to 220 of about 29,683 (253)

Microfluidic Technologies for cfDNA Isolation and Analysis [PDF]

Micromachines, 2019
Cell-free DNA (cfDNA), which promotes precision oncology, has received extensive concern because of its abilities to inform genomic mutations, tumor burden and drug resistance. The absolute quantification of cfDNA concentration has been proved as an independent prognostic biomarker of overall survival.
Yi Qiao, Jing Tu
exaly   +4 more sources

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The personal utility of cfDNA screening: Pregnant patients' experiences with cfDNA screening and views on expanded cfDNA panels

Journal of Genetic Counseling, 2019
AbstractPrenatal cell‐free DNA screening (cfDNA) provides more genetic risk information about the fetus than has ever been possible. At the same time, the rapid expansion of new cfDNA panels raises important questions about how to structure patient‐centered discussions that best support patients' decision‐making about its use. To address this question,
Ruth M, Farrell, Patricia K, Agatisa, Marsha M, Michie, Amy, Greene, Paul J, Ford   +4 more
openaire   +2 more sources

Association of cfDNA levels and bothrops envenomation

Toxicon, 2021
In the Amazon, around 90% of snakebites are caused by the Bothrops genus. Complications arising from Bothrops envenomations result from the inflammatory and coagulotoxic activities of the venom. The aim of this study was to investigate the potential of cell-free DNA (cfDNA) as a biomarker of severity in Bothrops snakebites. Patients were treated at the
Êndila, de Souza Barbosa, Hiochelson Najibe, Santos Ibiapina, Siuhelem, Rocha da Silva, Allyson Guimarães, Costa, Fernando Fonseca, Val, Iran, Mendonça-da-Silva, Luiz, Carlos de Lima Ferreira, Marco Aurélio, Sartim, Wuelton Marcelo, Monteiro, Gisely, Cardoso de Melo, Jacqueline, de Almeida Gonçalves Sachett   +10 more
openaire   +2 more sources

Deep cfDNA fragment end profiling enables cancer detection [PDF]

Molecular Cancer, 2022
Anastasia Koval, Ilgar Z Mamedov, Dmitry Shcherbo   +2 more
exaly   +4 more sources

cfDNA detection for HPV+ squamous cell carcinomas

Oral Oncology, 2021
High-risk human papillomavirus (HPV) is an etiologic factor in a spectrum of squamous cell carcinomas including anal, cervical, and oropharyngeal. HPV cell free DNA (cfDNA) is shed from the primary tumor into systemic circulation and can be detected using several platforms including quantitative PCR, digital droplet PCR, or next generation sequencing ...
Kate, Chatfield-Reed, Veronique P, Roche, Quintin, Pan   +2 more
openaire   +2 more sources

Assessing HER2 Amplification in Plasma cfDNA

2018
Digital PCR (dPCR) is a highly accurate method to determine DNA concentration. In dPCR, DNA is portioned into many discrete single entities, and these are analyzed individually for the presence or absence of a target molecule of interest. Here we describe how digital PCR can be employed to determine the presence of oncogenic amplification through ...
Garcia-Murillas, I, Turner, NC
openaire   +3 more sources

Predicting fetoplacental mosaicism during cfDNA-based NIPT

Current Opinion in Obstetrics & Gynecology, 2020
Purpose of review Cell-free DNA-based noninvasive prenatal testing (cfDNA-based NIPT) using maternal blood is highly sensitive for detecting fetal trisomies. However, false-positive and false-negative results can occur, which prevents NIPT from being a diagnostic test.
openaire   +2 more sources

cfDNA kao biomarker [PDF]

, 2017
Since the discovery of cfDNA (cell-free DNA), many of its applications in molecular medicine have been considered and researched: from diagnosing and monitoring tumors, and predicting disease outcome using specific biomarkers, to the detection and prediction of aberrant fetus development using noninvasive prenatal diagnostics.
openaire  

From cfDNA to Sequencing: Workflows and Potentials

2018
Cell-free DNA (cfDNA) is acquiring increasingly importance in oncologic clinical practice, mostly due to its role in predicting the onset of therapy resistance by following the mutation status changes of patients. In this field, high-sensitivity methods like next-generation sequencing (NGS) could help to accurately detect somatic mutations at low ...
Michela, Tebaldi, Samanta, Salvi
openaire   +2 more sources

Kidney cfDNA

The samples contain genomic sequencing data of cfDNA from healthy individuals and those with kidney disease.
openaire   +1 more source