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Molekulární mechanismy účinků cfDNA
2023The biological role of free circulating DNA is currently being investigated mainly in terms of the etiology of autoimmune conditions and cancer. It appears that the role of cfDNA of nuclear or mitochondrial origin in interacting with receptors of the innate immune system is quite complex and cfDNA is thus involved in a variety of molecular mechanisms ...
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Detection of fetal
Abstract Background An NGS‐based assay was developed to determine the presence or absence of paternally inherited genetic variants in cfDNA derived from the fetus in the plasma of pregnant women.
Klaus Rieneck +2 more
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The development of minimally-invasive diagnostic tools is crucial for improving outcomes and managing complex diseases such as cancer or sepsis. Cell-free DNA (cfDNA), fragments of DNA circulating in body fluids, holds promise as a basis for such diagnostic tools.
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cfDNA fragmentomics for preeclampsia prediction
To investigate whether cfDNA fragmentomic features have the potential to predict early-onset or late-onset PE, we performed WGS of plasma cfDNA (>10X final read depth) from pregnant women with PE (n=109 for early-onset PE, n=333 for late-onset PE) and sampling-gestation-matched healthy controls (n=476).openaire +1 more source
Using cfDNA and ctDNA as Oncologic Markers: A Path to Clinical Validation
International Journal of Molecular Sciences, 2023Jonathan Dao +2 more
exaly
preterm pregnants cfDNA Research
The cfDNA analysis of preterm pregnants recruited in Tianjin during three pregnancies was conducted to explore the dynamic change pattern.openaire +1 more source
Novel technologies in cfDNA analysis and potential utility in clinic
Chinese Journal of Cancer Research: Official Journal of China Anti-Cancer Association, Beijing Institute for Cancer Research, 2021Junya Peng, Yupei Zhao, Wenming Wu
exaly
Separation, Purification, and Detection of cfDNA in a Microfluidic Device
Biochip Journal, 2020Christian D Ahrberg +2 more
exaly