Results 211 to 220 of about 80,761 (294)

Iron pyrite nanocrystals as a sustainable nanozyme for colorimetric detection of ceftriaxone sodium in environmental samples. [PDF]

Sci Rep
Seyyed Alavi SM, Amjadi M, Manzoori JL.
europepmc   +1 more source

Perp Deficiency Induces Defective Negative Selection and Autoimmune Arthritis in Aged Mice

Aging Cell, Volume 25, Issue 5, May 2026.
Perp deficiency promotes age‐related autoimmunity. ABSTRACT Thymic negative selection is characterized by the apoptosis of autoreactive thymocytes and plays a critical role in maintaining self‐tolerance. Numerous apoptosis‐related genes influence cell fate during T‐cell development.
Yan Zhou, Junrong Li, Xiao Leng, Jiao Shi, Gan Zhang, Shan Chen, Dong Liu, Qian Deng, Yan He, Guixiu Shi, Ying Xu, Yuan Liu, Yantang Wang   +12 more
wiley   +1 more source

Chemical proteomics identifies signal peptidase IB (SpsB) as a target of the SOS response inhibitor OXF-077 and a regulator of quinolone resistance emergence in Staphylococcus aureus

Bradbury JD, Walsh TR, Lanyon-Hogg T.
europepmc   +1 more source

Phylogenetic analysis and susceptibility to antibiotics and phytogenics of <i>Riemerella anatipestifer</i> strains isolated in Poland. [PDF]

J Vet Res
Tyc J, Kalwasińska A, Olszewska-Tomczyk M, Woźniakowski G.   +3 more
europepmc   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, Volume 81, Issue 5, Page 1617-1634, May 2026.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Coral Venom and Toxins as Protection Against Crown-of-Thorns Sea Star Attack. [PDF]

Mol Ecol
Gorman LM, Huffmyer AS, Byrne M, Mills SC, Putnam HM.   +4 more
europepmc   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Prevalence and antimicrobial susceptibility profile of Staphylococcus aureus from meat, abattoir workers, equipment and water samples at Abergelle International Livestock Development PLC, Mekelle, Northern Ethiopia. [PDF]

BMC Microbiol
Tsegay HY, Sahle MG, Woldie BM, Abdelkadir KS.   +3 more
europepmc   +1 more source

Targeting PRMTs Creates Vulnerability of DNA Double‐Stand Break Repair Pathways, and Potentiates Chemotherapy Efficacy in TNBC

Cancer Science, Volume 117, Issue 5, Page 1273-1285, May 2026.
Our work makes the proof of concept that there is a clinical benefit to target both PRMT1 and PRMT5 to maximize the anti‐tumoral effect of chemotherapy in triple negative breast cancer. ABSTRACT Patients with triple‐negative breast cancer (ER−, PR−, and HER2−) are routinely treated with chemotherapies that induce DNA damage.
Charlène Thiebaut, Sébastien Martinez, Ludivine Pruvost, Louisane Eve, Rania El‐Botty, Laura Sourd, Elodie Montaudon, Ahmed Dahmani, Heloise Derrien, Stéphanie Sentis, Coralie Poulard, Elisabetta Marangoni, Olivier Trédan, Muriel Le Romancer   +13 more
wiley   +1 more source

Live-Cell Chemoproteomic Profiling Identifies the Uncharacterised Protein YbaA as a Direct Target of Ciprofloxacin in Escherichia coli

Seow TCY, Bradbury JD, Taylor EK, Bauer LG, Harvey M, Hreidarsdottir H, Saghbini SM, Wang Y, Thomas AM, Barbosa PS, Huber KVM, Isom GL, Lanyon-Hogg T.   +12 more
europepmc   +1 more source