Results 201 to 210 of about 80,761 (294)

Impact of brief telehealth interventions on parental stress and challenging behaviors of children with fragile X syndrome. [PDF]

Orphanet J Rare Dis
Miranda MF, Faundes V, Alliende MA, Santa María L.   +3 more
europepmc   +1 more source

BCR–ABL1 Drives Transcriptional Reprogramming of Chronic Myeloid Leukemia Cells for Immune Evasion Through C/EBPβ

MedComm, Volume 7, Issue 5, May 2026.
There is global immunosuppression during CML initiation and progression, which is directly driven by BCR–ABL1 expressing CML cells. On one hand, the BCR–ABL1 oncogene drives the differentiation of leukemia cells toward the neutrophil lineage. On the other hand, the oncogene also transcriptionally activates master immune regulators, including arginase ...
Xiaocui Lu, Hui Fang, Yuan Liu, Chang Liu, Xuexiu Fang, Atsuko Matsunaga, Stephanie F. Mori, Ting Zhang, Gavin Wang, George I. Zhou, Miao Yu, Haocheng Ding, Jorge Cortes, Bo Cheng, Tianxiang Hu   +14 more
wiley   +1 more source

Novel hybrid tri-polymer hyalurosomes: unlocking next-generation trans-tympanic therapeutics through multi-Scale evaluations. [PDF]

Int J Pharm X
Ahmed S, Attia H, Saher O.
europepmc   +1 more source

Mucin Type Drives Composition and Mucin Glycan Degradation of an In Vitro Synthetic Microbial Community

Environmental Microbiology, Volume 28, Issue 5, May 2026.
The human gut outer mucus layer hosts specific microbes. Using a synthetic mucin glycan‐degrading microbial community to mimic this mucosal microbiome, we show that mucin type affects microbial community composition, glycan degradation and metabolite production.
Maryse D. Berkhout, Carol de Ram, Merlijn P. van Gaal, Henk Schols, Clara Belzer, Caroline M. Plugge   +5 more
wiley   +1 more source

Ertapenem as an Antibiotic Prophylaxis for Colectomies and Laparotomies: A Systematic Review. [PDF]

Surg Infect (Larchmt)
Martinez Ugarte S, Fajemisin MO, Varman B, Towns PC, Chamely EA, Green RW, Rieger WD, Wootton SH, Kao LS.   +8 more
europepmc   +1 more source

A Novel Small Molecule Accelerates Early Persister Regrowth and Potentiates Antibiotic Killing via MdtL–DcrB

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
bymBDZ accelerates early regrowth of persister‐derived E. coli and potentiates antibiotic killing. Its activity requires the MdtL–DcrB axis and is associated with envelope‐linked transport changes that increase intracellular small‐molecule exposure during recovery, thereby enhancing clearance in early treatment windows. ABSTRACT Persister cells survive
Garin Park, Hyein Kim, Sooyeon Song
wiley   +1 more source

Triphenylphosphonium is an effective targeting moiety for plant mitochondria. [PDF]

New Phytol
Lazary S, Maman G, Binenbaum J, Ronen M, Tal I, Yariv E, Ben Yaakov S, Shani E, Weinstain R.   +8 more
europepmc   +1 more source

Fasting and Caloric Restriction Activate an ADIOL‐NHR‐91‐Kynurenine Pathway Signaling Axis to Promote Healthspan

Aging Cell, Volume 25, Issue 5, May 2026.
The steroid hormone ADIOL emerges as a key mediator of fasting–and caloric restriction–induced healthspan benefits in C. elegans. These regimens activate ADIOL production, which acts through the estrogen receptor β homolog NHR‐91 to reduce neural kynurenic acid levels and enhance healthspan independently of lifespan. ADIOL supplementation, even late in
Ana Guijarro‐Hernández, Shinja Yoo, George A. Lemieux, Sena Komatsu, Abdullah Q. Latiff, Rishika R. Patil, Kaveh Ashrafi   +6 more
wiley   +1 more source

Improved Step-by-Step qPCR Method for Absolute Telomere Length Measurement. [PDF]

Methods Protoc
Arshinova ES, Karpova NS, Terekhina OL, Nurbekov M, Burtovskaya MI.   +4 more
europepmc   +1 more source

Aging‐Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment

Aging Cell, Volume 25, Issue 5, May 2026.
In the aged ovarian TME, cancer cells exhibit increased succinate production. Elevated extracellular succinate activates the SUCNR1 receptor on Tregs, promoting their recruitment and contributing to an immunosuppressive environment. This leads to diminished anti‐tumor T cell responses and reduced survival.
Mary P. Udumula, Anjaly KM, Faraz Rashid, Mohammad Nematullah, Harshit Singh, Tanya Bhardwaj, Miriana Hijaz, Shailendra Giri, Eduardo N. Chini, Heather M. Gibson, Ramandeep Rattan   +10 more
wiley   +1 more source