Results 211 to 220 of about 8,204 (252)

Interplay of cGAS with chromatin

Trends in Biochemical Sciences, 2021
Recognition of DNA is an evolutionarily highly conserved mechanism of immunity. In mammals, the cGAS-STING pathway plays a central role in coupling DNA sensing to the execution of innate immune mechanisms, both in contexts of infection as well as in noninfectious settings of cellular stress and injury. The indiscriminate ability of double-stranded DNA (
Wischnewski, Marilena, Ablasser, Andrea
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The cGAS–STING pathway and cancer

Nature Cancer, 2022
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has emerged as a critical innate immune pathway that, following engagement by DNA, promotes distinct immune effector responses that can impact virtually all aspects of tumorigenesis, from malignant cell transformation to metastasis.
Natasha Samson, Andrea Ablasser
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cGAS–STING signaling

Current Biology, 2022
Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING, also known as TMEM173) constitute the major signaling pathway in vertebrates that senses non-self DNA and elicits potent immune responses. At the core of this pathway, cGAS senses double-stranded DNA (dsDNA) and synthesizes cyclic GMP-AMP (cGAMP).
Sun, Z., Hornung, V. ; https://orcid.org/0000-0002-4150-194X   +1 more
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CS-CGA: Compact and more Secure CGA

2011 17th IEEE International Conference on Networks, 2011
Cryptographically Generated Address (CGA) is one of the most novel security features introduced in IPv6 suite. CGA is designed to prevent addresses theft without relying on trust authority or additional security infrastructures. However, CGA is relatively computationally intensive, and bandwidth consuming.
Ahmad AlSa'deh, Feng Cheng 0002, Christoph Meinel   +2 more
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Translation stress and collided ribosomes are co-activators of cGAS

Molecular Cell, 2021
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to activate the innate immune system.
Aengus Stewart, Ramanujan Hegde, Szymon Juszkiewicz   +2 more
exaly   +1 more source

Step on the cGAS! Viral inhibition of cGAS phase separation with cytosolic DNA

Molecular Cell, 2021
Xu et al. (2021) uncover a conserved viral mechanism to subvert the innate immune system whereby herpesvirus tegument proteins suppress cGAS:DNA phase separation.
Shubhanjali, Minhas, Alex S, Holehouse
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Aspirin meets cGAS

Nature Reviews Rheumatology, 2019
Sensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (SLE). Activation of cGAS signalling requires its deacetylation, so might aspirin have therapeutic potential to treat SLE by acetylating cGAS?
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Inhibition by nuclear cGAS

Nature Reviews Molecular Cell Biology, 2018
Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis.
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Longevity steps on the cGAS

Science
A DNA repair function in a cytosolic sensor demonstrates a potential role in naked mole-rat ...
John C, Martinez, Andrei, Seluanov, Vera, Gorbunova   +2 more
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Agonists and Inhibitors of the cGAS-STING Pathway

Molecules
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is pivotal in immunotherapy. Several agonists and inhibitors of the cGAS-STING pathway have been developed and evaluated for the treatment of various diseases. The agonists
Xiaoxuan Yu, Xiaoyong Wang, Linxiang Cai   +2 more
exaly   +2 more sources