Results 221 to 230 of about 8,204 (252)

Free cGAS

Science Signaling
The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.
openaire   +2 more sources

The chromogranin-A (CgA) in prostate cancer

Archives of Gerontology and Geriatrics, 2006
Prostate cancer is one of the most frequent tumors in men. The neuroendocrine differentiation in prostate cancer has become more widely recognized and has attracted considerable attention as a potentially new finding with major diagnostic, prognostic and therapeutic implications. We investigated the role of the serum concentrations of CgA in a group of
RANNO S, MOTTA, Massimo, RAMPELLO E, RISINO C, BENNATI E, MALAGUARNERA, Mariano   +5 more
openaire   +3 more sources

Mitophagy and cGAS–STING crosstalk in neuroinflammation

Acta Pharmaceutica Sinica B
Mitophagy, essential for mitochondrial health, selectively degrades damaged mitochondria. It is intricately linked to the cGAS–STING pathway, which is crucial for innate immunity. This pathway responds to mitochondrial DNA and is associated with cellular
Jianming Wu, Betty Yuen Kwan Law, An-Guo Wu   +2 more
exaly   +2 more sources

Loosening the grip on nuclear cGAS

Nature Genetics, 2020
Maintaining ignorance to self-nucleic acids can prevent inflammatory diseases such as Aicardi–Goutieres syndrome (AGS). A new study finds that mutations in LSM11 and RNU7-1, which encode components of the histone messenger RNA–preprocessing complex, cause AGS by loosening the binding of cyclic GMP–AMP synthase (cGAS) to nucleosomes, thus enabling cGAS ...
Fiachra Humphries, Katherine A. Fitzgerald   +1 more
openaire   +2 more sources

Identification and functional characterization of cGAS and cGAS-like in snakehead Channa argus

Fish & Shellfish Immunology
In mammals, cyclic GMP-AMP synthase (cGAS) senses cytosolic dsDNA to trigger type I interferon (IFN) response via the sting signalling, but its regulatory role in fish remains unclear. In the present study, cGAS and cGAS-like (cGASL) were identified in the snakehead (Channa argus), but they differ in the organization of two domains, NTase domain, MAB21
Hong Qing Zhang, Long Wei Cai, Yu Hang Deng, Meng Xin Yan, Peng Fei Mu, Bo Li, Lan Hao Liu, P. Nie   +7 more
openaire   +2 more sources

Cellular functions of cGAS-STING signaling

Trends in Cell Biology, 2023
Pinglong Xu
exaly  

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

Cancer Cell, 2021
Jerry W Shay, Silvia Siteni, Mingyi Chen   +2 more
exaly  

Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity

Immunity, 2023

exaly  

CGAS

2007
Kwangmin Choi, Youngik Yang, Sun Kim
openaire   +1 more source

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

Cell, 2023
Jingti Deng
exaly