Results 11 to 20 of about 148,798 (282)

cGMP becomes a drug target [PDF]

Naunyn-Schmiedeberg's Archives of Pharmacology, 2012
Cyclic guanosine 3′,5′-monophosphate (cGMP) serves as a second messenger molecule, which regulates pleiotropic cellular functions in health and disease.
J. Schlossmann, Elisabeth Schinner
semanticscholar   +5 more sources

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action [PDF]

Pharmacological Reviews, 2010
To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by cyclic nucleotide phosphodiesterases (PDEs). Effects of cGMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation ...
S. Francis, J. Busch, J. Corbin
semanticscholar   +4 more sources

cGMP and cardiac hypertrophy [PDF]

BMC Pharmacology and Toxicology, 2015
Methods We used a highly sensitive cytosolic and membranetargeted Forster resonance energy transfer (FRET)based biosensors for cGMP and cAMP for real time measurements in freshly isolated sensor-trasngenic adult ventricular cardiomyocytes. Combined with single cell contractility measurements, biochemical techniques and whole-heart recording, the effect
Alexander Froese, Hariharan Subramanian, Daniela Hübscher, Viacheslav O. Nikolaev, Ruwan K. Perera, Ruwan K. Perera, Konrad R. Götz   +6 more
openaire   +2 more sources

Targeting the nitric oxide/cGMP signaling pathway to treat chronic pain

Neural Regeneration Research, 2023
Nitric oxide (NO)/cyclic guanosine 3′,5′-monophosphate (cGMP) signaling has been shown to act as a mediator involved in pain transmission and processing. In this review, we summarize and discuss the mechanisms of the NO/cGMP signaling pathway involved in
Dan-Yang Li, Shao-Jie Gao, Jia Sun, Long-Qing Zhang, Jia-Yi Wu, Fan-He Song, Dai-Qiang Liu, Ya-Qun Zhou, Wei Mei   +8 more
doaj   +1 more source

A novel pathway of cGMP [PDF]

BMC Pharmacology, 2011
Background Cardiac atrial natriuretic peptide (ANP) regulates arterial blood pressure, moderates cardiomyocyte growth, and stimulates angiogenesis and metabolism. ANP binds to the transmembrane guanylyl cyclase (GC) receptor, GCA to exert its diverse functions.
Beatrice Dankworth, Katharina Völker, Michael Hartmann, Marc Freichel, Birgit Gaßner, Martin Kruse, Olaf Pongs, Michael Klaiber, Viacheslav O. Nikolaev, Robert Feil, Michaela Kuhn   +10 more
openaire   +2 more sources

The Regulation of the cGMP-binding cGMP Phosphodiesterase by Proteins That Are Immunologically Related to γ Subunit of the Photoreceptor cGMP Phosphodiesterase [PDF]

Journal of Biological Chemistry, 1997
The cGMP phosphodiesterase from retinal rods (PDE-6) is an alphabetagamma2 heterotetramer. The alpha and beta subunits contain catalytic sites for cGMP hydrolysis, whereas the gamma subunits serve as a protein inhibitor of the enzyme. Visual excitation of photoreceptors enables the activated GTP-bound form of the G-protein transducin to remove the ...
Lochhead, A, Nekrasova, E, Arshavsky, V Y, Pyne, N J   +3 more
openaire   +3 more sources

Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum [PDF]

, 1985
The cellular slime mold Dictyostelium discoideum has an intracellular phosphodiesterase which specifically hydrolyzes cGMP. The enzyme is activated by low cGMP concentrations, and is involved in the reduction of chemoattractant-mediated elevations of ...
Baraniak, Janina,, Bulgakov, Roman,, Haastert, Peter J.M. van,, Jastorff, Bernd,, Kesbeke, Fanja,, Morr, Michael,, Petridis, Georg,, Seela, Frank,, Stec, Wojciech J.,   +8 more
core   +2 more sources

Plasma Cyclic Guanosine Monophosphate Is a Promising Biomarker of Clinically Significant Portal Hypertension in Patients With Liver Cirrhosis

Frontiers in Medicine, 2022
Introduction: Despite intensive research, reliable blood-derived parameters to detect clinically significant portal hypertension (CSPH) in patients with cirrhosis are lacking.
Lukas Sturm, Lukas Sturm, Dominik Bettinger, Lisa Roth, Katharina Zoldan, Laura Stolz, Chiara Gahm, Jan Patrick Huber, Marlene Reincke, Rafael Kaeser, Rafael Kaeser, Tobias Boettler, Wolfgang Kreisel, Robert Thimme, Michael Schultheiss   +14 more
doaj   +1 more source

Sildenafil Citrate-Restored eNOS and PDE5 Regulation in Sickle Cell Mouse Penis Prevents Priapism Via Control of Oxidative/Nitrosative Stress [PDF]

, 2013
Sildenafil citrate revolutionized the practice of sexual medicine upon its federal regulatory agency approval approximately 15 years ago as the prototypical phosphodiesterase type 5 inhibitor indicated for the treatment of male erectile dysfunction.
Berkowitz, DE, Bivalacqua, TJ, Burnett, AL, Champion, HC, Hsu, LL, Musicki, B   +5 more
core   +8 more sources

Removal of cumulus cells around 20 h after the start of in vitro maturation improves the meiotic competence of porcine oocytes via reduction in cAMP and cGMP levels

The Journal of Reproduction and Development, 2019
We examined the effect of the timing of removing cumulus cells surrounding porcine oocytes from small follicles (SFs, < 3 mm in diameter) and medium follicles (MFs; 3–6 mm in diameter) on the meiotic and developmental competence of the oocytes ...
Pilar FERRÉ-PUJOL, Xuan Khanh NGUYEN, Tomoki NAGAHARA, Thi Tra Mi BUI, Takuya WAKAI, Hiroaki FUNAHASHI   +5 more
doaj   +1 more source