Results 21 to 30 of about 62,675 (241)

Nitric Oxide-Independent cGMP Efflux in the Striatum of Rats Exposed to Carbon Monoxide as Determined by Microdialysis

Journal of Pharmacological Sciences, 2007
Extracellular cGMP in the striatum of rats exposed to 3000 ppm carbon monoxide (CO) or 8% O2 was decreased during the early period of exposure. Thereafter, extracellular cGMP in rats exposed to CO, but not 8% O2, was transiently increased. A nitric oxide
Shuichi Hara, Toshiji Mukai, Hajime Mizukami, Fumi Kuriiwa, Takashi Watanabe, Takahiko Endo   +5 more
doaj   +1 more source

cGMP interacts with tropomyosin and downregulates actin-tropomyosin-myosin complex interaction

Respiratory Research, 2018
Background The nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway, plays a critical role in the pathogenesis of pulmonary arterial hypertension (PAH); however, its exact molecular mechanism remains ...
Lihui Zou, Junhua Zhang, Jingli Han, Wenqing Li, Fei Su, Xiaomao Xu, Zhenguo Zhai, Fei Xiao   +7 more
doaj   +1 more source

Novel Alternative Splice Variants of cGMP-binding cGMP-specific Phosphodiesterase [PDF]

Journal of Biological Chemistry, 1998
After our recent findings that the amino-terminal portion of rat cGMP-binding, cGMP-specific phosphodiesterase (cGB-PDE) differs from those of bovine and human cGB-PDEs, we found two forms of canine cGB-PDE cDNAs (CFPDE5A1 and CFPDE5A2) in canine lung.
J, Kotera, K, Fujishige, H, Akatsuka, Y, Imai, N, Yanaka, K, Omori   +5 more
openaire   +2 more sources

A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis

Nature Communications, 2018
Nitric oxide (NO) inhibits thrombosis in part by stimulating cyclic guanosine monophosphate (cGMP) production and cGMP-dependent protein kinase I (cGKI) activity in platelets. Here, Wen et al.
Lai Wen, Susanne Feil, Markus Wolters, Martin Thunemann, Frank Regler, Kjestine Schmidt, Andreas Friebe, Marcus Olbrich, Harald Langer, Meinrad Gawaz, Cor de Wit, Robert Feil   +11 more
doaj   +1 more source

Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case. [PDF]

PLoS Computational Biology, 2016
Impaired nitric oxide (NO˙)-cyclic guanosine 3', 5'-monophosphate (cGMP) signaling has been observed in many cardiovascular disorders, including heart failure and pulmonary arterial hypertension. There are several enzymatic determinants of cGMP levels in
Farshid S Garmaroudi, Diane E Handy, Yang-Yu Liu, Joseph Loscalzo   +3 more
doaj   +1 more source

Correlative intravital imaging of cGMP signals and vasodilation in mice

Frontiers in Physiology, 2014
Cyclic guanosine monophosphate (cGMP) is an important signaling molecule and drug target in the cardiovascular system. It is well known that stimulation of the vascular nitric oxide (NO)-cGMP pathway results in vasodilation.
Martin eThunemann, Kjestine eSchmidt, Cor eDe Wit, Xiaoxing eHan, Rakesh K Jain, Dai eFukumura, Robert eFeil   +6 more
doaj   +1 more source

Nitric Oxide-cGMP Signaling Stimulates Erythropoiesis through Multiple Lineage-Specific Transcription Factors: Clinical Implications and a Novel Target for Erythropoiesis. [PDF]

PLoS ONE, 2016
Much attention has been directed to the physiological effects of nitric oxide (NO)-cGMP signaling, but virtually nothing is known about its hematologic effects.
Tohru Ikuta, Hassan Sellak, Nadine Odo, Adekunle D Adekile, Karin M L Gaensler   +4 more
doaj   +1 more source

Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes

Open Biology, 2022
Cyclic guanosine monophosphate (cGMP) signalling plays a fundamental role in many cell types, including platelets. cGMP has been implicated in platelet formation, but mechanistic detail about its spatio-temporal regulation in megakaryocytes (MKs) is ...
Yujing Zhang, Pascal Benz, Daniel Stehle, Shang Yang, Hendrikje Kurz, Susanne Feil, Georg Nagel, Robert Feil, Shiqiang Gao, Markus Bender   +9 more
doaj   +1 more source

Unresolved mystery of cyclic nucleotide second messengers, periplasmic acid phosphatases and bacterial natural competence

Microbial Cell
We recently characterized the competitive inhibition of cyclic AMP (cAMP) on three periplasmic acid phosphatases, AphAHi, NadNHi, and eP4 (HelHi), in Haemophilus influenzae Rd KW20. This inhibitory effect is vital for orchestrating the nutritional growth
Kristina Kronborg, Yong Everett Zhang
doaj   +1 more source

Hyperammonemia impairs long-term potentiation in hippocampus by altering the modulation of cGMP-degrading phosphodiesterase by protein kinase G

Neurobiology of Disease, 2004
Hyperammonemia impairs long-term potentiation (LTP) in hippocampus, by an unknown mechanism. LTP in hippocampal slices requires activation of the soluble guanylate cyclase (sGC)-protein kinase G (PKG)-cGMP-degrading phosphodiesterase pathway.
Pilar Monfort, Marı́a-Dolores Muñoz, Vicente Felipo   +2 more
doaj   +1 more source