Results 21 to 30 of about 55,160 (145)

A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis

Nature Communications, 2018
Nitric oxide (NO) inhibits thrombosis in part by stimulating cyclic guanosine monophosphate (cGMP) production and cGMP-dependent protein kinase I (cGKI) activity in platelets. Here, Wen et al.
Lai Wen, Susanne Feil, Markus Wolters, Martin Thunemann, Frank Regler, Kjestine Schmidt, Andreas Friebe, Marcus Olbrich, Harald Langer, Meinrad Gawaz, Cor de Wit, Robert Feil   +11 more
doaj   +1 more source

Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case. [PDF]

PLoS Computational Biology, 2016
Impaired nitric oxide (NO˙)-cyclic guanosine 3', 5'-monophosphate (cGMP) signaling has been observed in many cardiovascular disorders, including heart failure and pulmonary arterial hypertension. There are several enzymatic determinants of cGMP levels in
Farshid S Garmaroudi, Diane E Handy, Yang-Yu Liu, Joseph Loscalzo   +3 more
doaj   +1 more source

Correlative intravital imaging of cGMP signals and vasodilation in mice

Frontiers in Physiology, 2014
Cyclic guanosine monophosphate (cGMP) is an important signaling molecule and drug target in the cardiovascular system. It is well known that stimulation of the vascular nitric oxide (NO)-cGMP pathway results in vasodilation.
Martin eThunemann, Kjestine eSchmidt, Cor eDe Wit, Xiaoxing eHan, Rakesh K Jain, Dai eFukumura, Robert eFeil   +6 more
doaj   +1 more source

Unresolved mystery of cyclic nucleotide second messengers, periplasmic acid phosphatases and bacterial natural competence

Microbial Cell
We recently characterized the competitive inhibition of cyclic AMP (cAMP) on three periplasmic acid phosphatases, AphAHi, NadNHi, and eP4 (HelHi), in Haemophilus influenzae Rd KW20. This inhibitory effect is vital for orchestrating the nutritional growth
Kristina Kronborg, Yong Everett Zhang
doaj   +1 more source

Continuous use of glycomacropeptide in the nutritional management of patients with phenylketonuria: a clinical perspective

Orphanet Journal of Rare Diseases, 2021
Background In phenylketonuria (PKU), modified casein glycomacropeptide supplements (CGMP-AA) are used as an alternative to the traditional phenylalanine (Phe)-free L-amino acid supplements (L-AA).
Maria João Pena, Alex Pinto, Manuela Ferreira de Almeida, Catarina de Sousa Barbosa, Paula Cristina Ramos, Sara Rocha, Arlindo Guimas, Rosa Ribeiro, Esmeralda Martins, Anabela Bandeira, Cláudia Camila Dias, Anita MacDonald, Nuno Borges, Júlio César Rocha   +13 more
doaj   +1 more source

Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes

Open Biology, 2022
Cyclic guanosine monophosphate (cGMP) signalling plays a fundamental role in many cell types, including platelets. cGMP has been implicated in platelet formation, but mechanistic detail about its spatio-temporal regulation in megakaryocytes (MKs) is ...
Yujing Zhang, Pascal Benz, Daniel Stehle, Shang Yang, Hendrikje Kurz, Susanne Feil, Georg Nagel, Robert Feil, Shiqiang Gao, Markus Bender   +9 more
doaj   +1 more source

Nitric Oxide-cGMP Signaling Stimulates Erythropoiesis through Multiple Lineage-Specific Transcription Factors: Clinical Implications and a Novel Target for Erythropoiesis. [PDF]

PLoS ONE, 2016
Much attention has been directed to the physiological effects of nitric oxide (NO)-cGMP signaling, but virtually nothing is known about its hematologic effects.
Tohru Ikuta, Hassan Sellak, Nadine Odo, Adekunle D Adekile, Karin M L Gaensler   +4 more
doaj   +1 more source

Partial Reconstitution of Photoreceptor cGMP Phosphodiesterase Characteristics in cGMP Phosphodiesterase-5 [PDF]

Journal of Biological Chemistry, 2001
Photoreceptor cGMP phosphodiesterases (PDE6) are uniquely qualified to serve as effector enzymes in the vertebrate visual transduction cascade. In the dark-adapted photoreceptors, the activity of PDE6 is blocked via tight association with the inhibitory gamma-subunits (Pgamma).
A E, Granovsky, N O, Artemyev
openaire   +2 more sources

cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5 [PDF]

Biochemical Journal, 2003
The physiological effects of cGMP are largely determined by the activities of intracellular receptors, including cGMP-dependent protein kinase (PKG) and cGMP-binding cyclic nucleotide phosphodiesterases (PDEs), and the distribution of cGMP among these receptors dictates activity of the signalling pathway.
Jun, Kotera, Kennard A, Grimes, Jackie D, Corbin, Sharron H, Francis   +3 more
openaire   +2 more sources

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source