Results 21 to 30 of about 148,798 (282)
cGMP: a unique 2nd messenger molecule – recent developments in cGMP research and development
Naunyn-Schmiedeberg's Archives of Pharmacology, 2019 Cyclic guanosine monophosphate (cGMP) is a unique second messenger molecule formed in different cell types and tissues. cGMP targets a variety of downstream effector molecules and, thus, elicits a very broad variety of cellular effects. Its production is
A. Friebe, P. Sandner, A. Schmidtko
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Regulation of intracellular cyclic GMP concentration by light and calcium in electropermeabilized rod photoreceptors. [PDF]
, 1994 This study examines the regulation of cGMP by illumination and by calcium during signal transduction in vertebrate retinal photoreceptor cells. We employed an electropermeabilized rod outer segment (EP-ROS) preparation which permits perfusion of low ...
Coccia, V J, Cote, Rick H.
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Communications Biology, 2023 The occurrence of NO/cGMP signalling in cardiac cells is a matter of debate. Recent measurements with a FRET-based cGMP indicator in isolated cardiac cells revealed NO-induced cGMP signals in cardiac fibroblasts while cardiomyocytes were devoid of these ...
Lukas Menges +7 more
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Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
Proceedings of the National Academy of Sciences of the United States of America, 1989 Nitric oxide, which mediates influences of numerous neurotransmitters and modulators on vascular smooth muscle and leukocytes, can be formed in the brain from arginine by an enzymatic activity that stoichiometrically generates citrulline.
D. Bredt, S. Snyder
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Deciphering cGMP signatures and cGMP-dependent pathways in plant defence [PDF]
Plant Signaling & Behavior, 2009 The second messenger, 3′,5′-cyclic monophosphate (cGMP), is a critical component of many different processes in plants while guanylyl cyclases that catalyse the formation of cGMP from GTP have remained somewhat elusive in higher plants. Consequently, two major aims are the discovery of novel GCs and the identification of cGMP mediated processes ...
Meier S. +5 more
openaire +4 more sources
Estimating the rate constant of cyclic GMP hydrolysis by activated phosphodiesterase in photoreceptors [PDF]
, 2008 The early steps of light response occur in the outer segment of rod and cone photoreceptor. They involve the hydrolysis of cGMP, a soluble cyclic nucleotide, that gates ionic channels located in the outer segment membrane. We shall study here the rate by
Holcman, david, Reingruber, Juergen
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β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes
eLife, 2020 Cardiomyocyte β3-adrenoceptors (β3-ARs) coupled to soluble guanylyl cyclase (sGC)-dependent production of the second messenger 3’,5’-cyclic guanosine monophosphate (cGMP) have been shown to protect from heart failure.
Sophie Schobesberger +9 more
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The role of cGMP and PKG-I in spinal nociceptive processing [PDF]
, 2005 First paragraph (this article has no abstract) Persistent stimulation of nociceptors results in sensitization of nociceptive sensory neurons, which is associated with hyperalgesia and allodynia.
Geisslinger, Gerd +5 more
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Scientia Pharmaceutica, 2019 Phosphodiesterase type 5 (PDE5) is an important enzyme associated with the hydrolysis of cyclic guanosine monophosphate (cGMP) to guanosine monophosphate (GMP).
Ivan Pires de Oliveira +2 more
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PLoS ONE, 2022 IntroductionManagement of phenylketonuria (PKU) is mainly achieved through dietary control with limited intake of phenylalanine (Phe) from food, supplemented with low protein (LP) food and a mixture of free synthetic (FS) amino acids (AA) (FSAA).
Kirsten K Ahring +14 more
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