Results 71 to 80 of about 148,798 (282)

Novel Alternative Splice Variants of cGMP-binding cGMP-specific Phosphodiesterase [PDF]

Journal of Biological Chemistry, 1998
After our recent findings that the amino-terminal portion of rat cGMP-binding, cGMP-specific phosphodiesterase (cGB-PDE) differs from those of bovine and human cGB-PDEs, we found two forms of canine cGB-PDE cDNAs (CFPDE5A1 and CFPDE5A2) in canine lung.
Hiroyuki Akatsuka, Kenji Omori, Noriyuki Yanaka, Kotomi Fujishige, Jun Kotera, Yuji Imai   +5 more
openaire   +3 more sources

The Possible Role of TASK Channels in Rank-Ordered Recruitment of Motoneurons in the Dorsolateral Part of the Trigeminal Motor Nucleus. [PDF]

, 2016
Because a rank-ordered recruitment of motor units occurs during isometric contraction of jaw-closing muscles, jaw-closing motoneurons (MNs) may be recruited in a manner dependent on their soma sizes or input resistances (IRs). In the dorsolateral part of
Emura, Norihito, Fukatsu, Yuki, Furutani, Kazuharu, Kaneko, Takeshi, Kang, Youngnam, Kurachi, Yoshihisa, Kuramoto, Eriko, Maeda, Yoshinobu, Morita, Yukako, Nishimura, Kayo, Okamoto, Keiko, Okazawa, Makoto, Saito, Mitsuru, Sato, Hajime, Takada, Kenji, Tanaka, Chie, Toyoda, Hiroki, Xu Yin, Dong, Yamashiro, Takashi   +18 more
core   +2 more sources

cGMP Signaling and Vascular Smooth Muscle Cell Plasticity

Journal of Cardiovascular Development and Disease, 2018
Cyclic GMP regulates multiple cell types and functions of the cardiovascular system. This review summarizes the effects of cGMP on the growth and survival of vascular smooth muscle cells (VSMCs), which display remarkable phenotypic plasticity during the ...
Moritz Lehners, Hyazinth Dobrowinski, Susanne Feil, Robert Feil   +3 more
doaj   +1 more source

Partial Reconstitution of Photoreceptor cGMP Phosphodiesterase Characteristics in cGMP Phosphodiesterase-5 [PDF]

Journal of Biological Chemistry, 2001
Photoreceptor cGMP phosphodiesterases (PDE6) are uniquely qualified to serve as effector enzymes in the vertebrate visual transduction cascade. In the dark-adapted photoreceptors, the activity of PDE6 is blocked via tight association with the inhibitory gamma-subunits (Pgamma).
Nikolai O. Artemyev, Alexey E. Granovsky
openaire   +3 more sources

Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide

Frontiers in Neuroscience, 2019
PDE9A is a cGMP-specific phosphodiesterase expressed in neurons throughout the brain that has attracted attention as a therapeutic target to treat cognitive disorders.
John F. Harms, Frank S. Menniti, Christopher J. Schmidt   +2 more
doaj   +1 more source

Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase.

Journal of Biological Chemistry, 1990
A bovine lung cGMP-binding phosphodiesterase (cG-BPDE) was purified to homogeneity and exhibited specific cGMP hydrolytic (Km = 5.6 microM) and cGMP binding (half-maximum approximately 0.2 microM) activities which comigrated throughout the purification.
Melissa K. Thomas, Sharron H. Francis, Jackie D. Corbin   +2 more
openaire   +3 more sources

cAMP activates adenylate and guanylate cyclase of Dictyostelium discoideum cells by binding to different classes of cell-surface receptors. A study with extracellular Ca2+ [PDF]

, 1985
cAMP induces a transient increase of cAMP and cGMP levels in Dictyostelium discoideum cells. Fast binding experiments reveal three types of cAMP-binding site (S, H and L), which have different off-rates (t0.5, 0.7-15 s) and different affinities (Kd, 15 ...
Brachet, Bumann, De Wit, Devreotes, Dinauer, Gerisch, Gerisch, Janssens, Juliani, Kay, Konijn, Leichtling, Marin, Mato, Pannbacker, Roos, Schaap, Shaffer, Stadel, Toews, Van Haastert, Van Haastert, Van Haastert, Van Haastert, Van Haastert, Van Haastert   +25 more
core   +3 more sources

Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain

Frontiers in Molecular Neuroscience, 2014
Activation of guanylate cyclase-C (GC-C) expressed predominantly on intestinal epithelial cells by guanylin, uroguanylin or the closely related GC-C agonist peptide, linaclotide, stimulates generation and release of cyclic guanosine-3’,5’-monophosphate (
Gerhard eHannig, Boris eTchernychev, Caroline B Kurtz, Alexander P Bryant, Mark G Currie, Inmaculada eSilos-Santiago   +5 more
doaj   +1 more source

Mechanisms associated with cGMP binding and activation of cGMP-dependent protein kinase [PDF]

Proceedings of the National Academy of Sciences, 2003
Using small-angle x-ray scattering, we have observed the cGMP-induced elongation of an active, cGMP-dependent, monomeric deletion mutant of cGMP-dependent protein kinase (Δ 1–52 PKG-Iβ). On saturation with cGMP, the radius of gyration of Δ 1–52 PKG-Iβ increases from 29.4 ± 0.1 Å to 40.1 ± 0.7
Kennard A. Grimes, Jun Kotera, Michael E. Wall, Jill Trewhella, Sharron H. Francis, Brian MacDonald, Robyn Richie-Jannetta, Rowena R. Gibson, Jackie D. Corbin   +8 more
openaire   +3 more sources

Shear-Induced Nitric Oxide Production by Endothelial Cells

, 2016
We present a biochemical model of the wall shear stress (WSS)-induced activation of endothelial nitric oxide synthase (eNOS) in an endothelial cell (EC).
Laughlin, Justin G., Rangamani, Padmini, Sriram, Krishna, Tartakovsky, Daniel M.   +3 more
core   +1 more source